IKZF3_HUMAN
ID IKZF3_HUMAN Reviewed; 509 AA.
AC Q9UKT9; B4DVV5; Q69BL6; Q69BL7; Q69BL8; Q69BL9; Q69BM0; Q69BM1; Q69BM2;
AC Q69BM3; Q69BM5; Q8N574; Q8WWQ9; Q8WWR0; Q8WWR1; Q8WWR2; Q8WWR3;
DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=Zinc finger protein Aiolos;
DE AltName: Full=Ikaros family zinc finger protein 3;
GN Name=IKZF3; Synonyms=ZNFN1A3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Lymphoma;
RX PubMed=10552935; DOI=10.1006/geno.1999.5949;
RA Hosokawa Y., Maeda Y., Takahashi E., Suzuki M., Seto M.;
RT "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA
RT cloning, tissue expression pattern, and chromosomal mapping.";
RL Genomics 61:326-329(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6), AND ALTERNATIVE
RP SPLICING.
RC TISSUE=Lymphoid tissue;
RX PubMed=11745366;
RX DOI=10.1002/1521-4141(200112)31:12<3469::aid-immu3469>3.0.co;2-g;
RA Liippo J.P., Nera K.P., Veistinen E., Lahdesmaki A., Postila V., Kimby E.,
RA Riikonen P., Hammarstrom L., Pelkonen J., Lassila O.;
RT "Both normal and leukemic B lymphocytes express multiple isoforms of the
RT human Aiolos gene.";
RL Eur. J. Immunol. 31:3469-3474(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 7; 8; 9; 10; 11; 12; 13; 14 AND 15),
RP SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND ALTERNATIVE
RP SPLICING.
RX PubMed=17646674; DOI=10.1242/jcs.007344;
RA Caballero R., Setien F., Lopez-Serra L., Boix-Chornet M., Fraga M.F.,
RA Ropero S., Megias D., Alaminos M., Sanchez-Tapia E.M., Montoya M.C.,
RA Esteller M., Gonzalez-Sarmiento R., Ballestar E.;
RT "Combinatorial effects of splice variants modulate function of Aiolos.";
RL J. Cell Sci. 120:2619-2630(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 16).
RC TISSUE=Spleen, and Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION, INTERACTION WITH HRAS, SUBCELLULAR LOCATION, AND PHOSPHORYLATION.
RX PubMed=10369681; DOI=10.1093/emboj/18.12.3419;
RA Romero F., Martinez-A C., Camonis J., Rebollo A.;
RT "Aiolos transcription factor controls cell death in T cells by regulating
RT Bcl-2 expression and its cellular localization.";
RL EMBO J. 18:3419-3430(1999).
RN [9]
RP INTERACTION WITH IKZF4 AND IKZF5.
RX PubMed=10978333; DOI=10.1074/jbc.m005457200;
RA Perdomo J., Holmes M., Chong B., Crossley M.;
RT "Eos and pegasus, two members of the Ikaros family of proteins with
RT distinct DNA binding activities.";
RL J. Biol. Chem. 275:38347-38354(2000).
RN [10]
RP INTERACTION WITH BCL21L, AND PHOSPHORYLATION.
RX PubMed=11714801; DOI=10.4049/jimmunol.167.11.6366;
RA Rebollo A., Ayllon V., Fleischer A., Martinez C.A., Zaballos A.;
RT "The association of Aiolos transcription factor and Bcl-xL is involved in
RT the control of apoptosis.";
RL J. Immunol. 167:6366-6373(2001).
RN [11]
RP INTERACTION WITH FOXP3, AND INDUCTION.
RX PubMed=20676092; DOI=10.1038/ni.1915;
RA Gandhi R., Kumar D., Burns E.J., Nadeau M., Dake B., Laroni A., Kozoriz D.,
RA Weiner H.L., Quintana F.J.;
RT "Activation of the aryl hydrocarbon receptor induces human type 1
RT regulatory T cell-like and Foxp3(+) regulatory T cells.";
RL Nat. Immunol. 11:846-853(2010).
RN [12]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-326, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [14]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-61; LYS-73; LYS-100 AND LYS-245,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [15]
RP INVOLVEMENT IN IMD84, VARIANT IMD84 ARG-159, CHARACTERIZATION OF VARIANT
RP IMD84 ARG-159, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, DOMAIN, AND REGION.
RX PubMed=34155405; DOI=10.1038/s41590-021-00951-z;
RA Yamashita M., Kuehn H.S., Okuyama K., Okada S., Inoue Y., Mitsuiki N.,
RA Imai K., Takagi M., Kanegane H., Takeuchi M., Shimojo N., Tsumura M.,
RA Padhi A.K., Zhang K.Y.J., Boisson B., Casanova J.L., Ohara O.,
RA Rosenzweig S.D., Taniuchi I., Morio T.;
RT "A variant in human AIOLOS impairs adaptive immunity by interfering with
RT IKAROS.";
RL Nat. Immunol. 22:893-903(2021).
RN [16]
RP VARIANT GLN-277.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- FUNCTION: Transcription factor that plays an important role in the
CC regulation of lymphocyte differentiation. Plays an essential role in
CC regulation of B-cell differentiation, proliferation and maturation to
CC an effector state. Involved in regulating BCL2 expression and
CC controlling apoptosis in T-cells in an IL2-dependent manner.
CC {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:34155405}.
CC -!- SUBUNIT: Homodimer. Heterodimer with other IKAROS family members.
CC Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with
CC HRAS. Interacts with FOXP3; this interaction may be required for
CC silencing target genes and regulating the suppressive activity of
CC FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform
CC Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L.
CC Associates with histone deacetylase complexes containing HDAC1, MTA2
CC and SIN3A. {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:10978333,
CC ECO:0000269|PubMed:11714801, ECO:0000269|PubMed:17646674,
CC ECO:0000269|PubMed:20676092, ECO:0000269|PubMed:34155405}.
CC -!- INTERACTION:
CC Q9UKT9; O94929: ABLIM3; NbExp=4; IntAct=EBI-747204, EBI-351267;
CC Q9UKT9; O94929-2: ABLIM3; NbExp=3; IntAct=EBI-747204, EBI-11961672;
CC Q9UKT9; A0A0S2Z4Y8: AKAP10; NbExp=3; IntAct=EBI-747204, EBI-16428921;
CC Q9UKT9; Q99996-2: AKAP9; NbExp=3; IntAct=EBI-747204, EBI-9641546;
CC Q9UKT9; Q49AR9: ANKS1A; NbExp=5; IntAct=EBI-747204, EBI-11954519;
CC Q9UKT9; P29972: AQP1; NbExp=6; IntAct=EBI-747204, EBI-745213;
CC Q9UKT9; Q15052: ARHGEF6; NbExp=3; IntAct=EBI-747204, EBI-1642523;
CC Q9UKT9; Q9H6L4: ARMC7; NbExp=9; IntAct=EBI-747204, EBI-742909;
CC Q9UKT9; Q8N8Y2: ATP6V0D2; NbExp=3; IntAct=EBI-747204, EBI-3923949;
CC Q9UKT9; Q8N5M1: ATPAF2; NbExp=10; IntAct=EBI-747204, EBI-1166928;
CC Q9UKT9; O75934: BCAS2; NbExp=5; IntAct=EBI-747204, EBI-1050106;
CC Q9UKT9; P51451: BLK; NbExp=3; IntAct=EBI-747204, EBI-2105445;
CC Q9UKT9; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-747204, EBI-2548012;
CC Q9UKT9; Q13895: BYSL; NbExp=3; IntAct=EBI-747204, EBI-358049;
CC Q9UKT9; Q9NX04: C1orf109; NbExp=6; IntAct=EBI-747204, EBI-8643161;
CC Q9UKT9; Q53TS8: C2CD6; NbExp=3; IntAct=EBI-747204, EBI-739879;
CC Q9UKT9; Q9NP86: CABP5; NbExp=5; IntAct=EBI-747204, EBI-10311131;
CC Q9UKT9; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-747204, EBI-11530605;
CC Q9UKT9; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-747204, EBI-744545;
CC Q9UKT9; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-747204, EBI-10171570;
CC Q9UKT9; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-747204, EBI-1104933;
CC Q9UKT9; Q2TAC2-2: CCDC57; NbExp=5; IntAct=EBI-747204, EBI-10961624;
CC Q9UKT9; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-747204, EBI-10175300;
CC Q9UKT9; Q16543: CDC37; NbExp=3; IntAct=EBI-747204, EBI-295634;
CC Q9UKT9; O00311: CDC7; NbExp=3; IntAct=EBI-747204, EBI-374980;
CC Q9UKT9; Q07002: CDK18; NbExp=3; IntAct=EBI-747204, EBI-746238;
CC Q9UKT9; P11802: CDK4; NbExp=6; IntAct=EBI-747204, EBI-295644;
CC Q9UKT9; P38936: CDKN1A; NbExp=3; IntAct=EBI-747204, EBI-375077;
CC Q9UKT9; P55273: CDKN2D; NbExp=5; IntAct=EBI-747204, EBI-745859;
CC Q9UKT9; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-747204, EBI-749051;
CC Q9UKT9; Q9Y6H1: CHCHD2; NbExp=4; IntAct=EBI-747204, EBI-2321769;
CC Q9UKT9; P61024: CKS1B; NbExp=3; IntAct=EBI-747204, EBI-456371;
CC Q9UKT9; P51800-3: CLCNKA; NbExp=3; IntAct=EBI-747204, EBI-11980535;
CC Q9UKT9; Q9UBL6-2: CPNE7; NbExp=3; IntAct=EBI-747204, EBI-12012272;
CC Q9UKT9; P53673: CRYBA4; NbExp=3; IntAct=EBI-747204, EBI-7519711;
CC Q9UKT9; P56545-3: CTBP2; NbExp=3; IntAct=EBI-747204, EBI-10171902;
CC Q9UKT9; Q86UW9: DTX2; NbExp=3; IntAct=EBI-747204, EBI-740376;
CC Q9UKT9; Q5JVL4: EFHC1; NbExp=13; IntAct=EBI-747204, EBI-743105;
CC Q9UKT9; Q9H6Z9: EGLN3; NbExp=3; IntAct=EBI-747204, EBI-1175354;
CC Q9UKT9; Q08426: EHHADH; NbExp=3; IntAct=EBI-747204, EBI-2339219;
CC Q9UKT9; Q15006: EMC2; NbExp=3; IntAct=EBI-747204, EBI-359031;
CC Q9UKT9; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-747204, EBI-744099;
CC Q9UKT9; O15197-2: EPHB6; NbExp=3; IntAct=EBI-747204, EBI-10182490;
CC Q9UKT9; Q8IYI6: EXOC8; NbExp=7; IntAct=EBI-747204, EBI-742102;
CC Q9UKT9; Q9NQT4: EXOSC5; NbExp=7; IntAct=EBI-747204, EBI-371876;
CC Q9UKT9; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-747204, EBI-11986315;
CC Q9UKT9; Q9Y247: FAM50B; NbExp=3; IntAct=EBI-747204, EBI-742802;
CC Q9UKT9; Q9NW38: FANCL; NbExp=3; IntAct=EBI-747204, EBI-2339898;
CC Q9UKT9; O95363: FARS2; NbExp=6; IntAct=EBI-747204, EBI-2513774;
CC Q9UKT9; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-747204, EBI-10244131;
CC Q9UKT9; Q13643: FHL3; NbExp=4; IntAct=EBI-747204, EBI-741101;
CC Q9UKT9; Q9BZS1: FOXP3; NbExp=2; IntAct=EBI-747204, EBI-983719;
CC Q9UKT9; O43559: FRS3; NbExp=3; IntAct=EBI-747204, EBI-725515;
CC Q9UKT9; P55040: GEM; NbExp=8; IntAct=EBI-747204, EBI-744104;
CC Q9UKT9; Q9NYA3: GOLGA6A; NbExp=3; IntAct=EBI-747204, EBI-11163335;
CC Q9UKT9; P62993: GRB2; NbExp=8; IntAct=EBI-747204, EBI-401755;
CC Q9UKT9; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-747204, EBI-14103818;
CC Q9UKT9; P52597: HNRNPF; NbExp=3; IntAct=EBI-747204, EBI-352986;
CC Q9UKT9; P31273: HOXC8; NbExp=3; IntAct=EBI-747204, EBI-1752118;
CC Q9UKT9; Q9UBY9: HSPB7; NbExp=3; IntAct=EBI-747204, EBI-739361;
CC Q9UKT9; Q9UKT9: IKZF3; NbExp=4; IntAct=EBI-747204, EBI-747204;
CC Q9UKT9; Q9H5V7: IKZF5; NbExp=2; IntAct=EBI-747204, EBI-2685636;
CC Q9UKT9; Q8WYH8: ING5; NbExp=3; IntAct=EBI-747204, EBI-488533;
CC Q9UKT9; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-747204, EBI-2556193;
CC Q9UKT9; Q92993: KAT5; NbExp=6; IntAct=EBI-747204, EBI-399080;
CC Q9UKT9; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-747204, EBI-8472129;
CC Q9UKT9; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-747204, EBI-14069005;
CC Q9UKT9; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-747204, EBI-6426443;
CC Q9UKT9; P08727: KRT19; NbExp=3; IntAct=EBI-747204, EBI-742756;
CC Q9UKT9; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-747204, EBI-726510;
CC Q9UKT9; Q8TCE9: LGALS14; NbExp=8; IntAct=EBI-747204, EBI-10274069;
CC Q9UKT9; P25800: LMO1; NbExp=4; IntAct=EBI-747204, EBI-8639312;
CC Q9UKT9; P25791: LMO2; NbExp=3; IntAct=EBI-747204, EBI-739696;
CC Q9UKT9; P25791-3: LMO2; NbExp=3; IntAct=EBI-747204, EBI-11959475;
CC Q9UKT9; P61968: LMO4; NbExp=3; IntAct=EBI-747204, EBI-2798728;
CC Q9UKT9; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-747204, EBI-739832;
CC Q9UKT9; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-747204, EBI-2341787;
CC Q9UKT9; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-747204, EBI-77889;
CC Q9UKT9; Q96A72: MAGOHB; NbExp=7; IntAct=EBI-747204, EBI-746778;
CC Q9UKT9; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-747204, EBI-348259;
CC Q9UKT9; Q8IVT4: MGC50722; NbExp=5; IntAct=EBI-747204, EBI-14086479;
CC Q9UKT9; Q9UJV3-2: MID2; NbExp=5; IntAct=EBI-747204, EBI-10172526;
CC Q9UKT9; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-747204, EBI-2548751;
CC Q9UKT9; Q8IVT2: MISP; NbExp=5; IntAct=EBI-747204, EBI-2555085;
CC Q9UKT9; Q13064: MKRN3; NbExp=3; IntAct=EBI-747204, EBI-2340269;
CC Q9UKT9; Q6PF18: MORN3; NbExp=7; IntAct=EBI-747204, EBI-9675802;
CC Q9UKT9; Q13084: MRPL28; NbExp=3; IntAct=EBI-747204, EBI-723426;
CC Q9UKT9; Q96EL3: MRPL53; NbExp=3; IntAct=EBI-747204, EBI-2513715;
CC Q9UKT9; Q8N6N6: NATD1; NbExp=3; IntAct=EBI-747204, EBI-8656665;
CC Q9UKT9; Q9HC98: NEK6; NbExp=5; IntAct=EBI-747204, EBI-740364;
CC Q9UKT9; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-747204, EBI-11750983;
CC Q9UKT9; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-747204, EBI-10271199;
CC Q9UKT9; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-747204, EBI-744782;
CC Q9UKT9; P29474: NOS3; NbExp=3; IntAct=EBI-747204, EBI-1391623;
CC Q9UKT9; Q9BRJ7: NUDT16L1; NbExp=3; IntAct=EBI-747204, EBI-2949792;
CC Q9UKT9; Q9NPJ8-3: NXT2; NbExp=3; IntAct=EBI-747204, EBI-10698339;
CC Q9UKT9; Q9UMX2: OAZ3; NbExp=3; IntAct=EBI-747204, EBI-10281601;
CC Q9UKT9; Q9UJX0: OSGIN1; NbExp=5; IntAct=EBI-747204, EBI-9057006;
CC Q9UKT9; Q5JVF3: PCID2; NbExp=3; IntAct=EBI-747204, EBI-1051701;
CC Q9UKT9; Q17RL8: PDZD4; NbExp=3; IntAct=EBI-747204, EBI-10239064;
CC Q9UKT9; Q99471: PFDN5; NbExp=7; IntAct=EBI-747204, EBI-357275;
CC Q9UKT9; O00459: PIK3R2; NbExp=4; IntAct=EBI-747204, EBI-346930;
CC Q9UKT9; Q13526: PIN1; NbExp=8; IntAct=EBI-747204, EBI-714158;
CC Q9UKT9; Q16512: PKN1; NbExp=3; IntAct=EBI-747204, EBI-602382;
CC Q9UKT9; Q6PIY2: POLM; NbExp=3; IntAct=EBI-747204, EBI-10253863;
CC Q9UKT9; O15160: POLR1C; NbExp=9; IntAct=EBI-747204, EBI-1055079;
CC Q9UKT9; Q96T49: PPP1R16B; NbExp=7; IntAct=EBI-747204, EBI-10293968;
CC Q9UKT9; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-747204, EBI-2557469;
CC Q9UKT9; Q13131: PRKAA1; NbExp=3; IntAct=EBI-747204, EBI-1181405;
CC Q9UKT9; P54646: PRKAA2; NbExp=3; IntAct=EBI-747204, EBI-1383852;
CC Q9UKT9; O43741: PRKAB2; NbExp=11; IntAct=EBI-747204, EBI-1053424;
CC Q9UKT9; Q99633: PRPF18; NbExp=3; IntAct=EBI-747204, EBI-2798416;
CC Q9UKT9; P25786: PSMA1; NbExp=3; IntAct=EBI-747204, EBI-359352;
CC Q9UKT9; Q13882: PTK6; NbExp=3; IntAct=EBI-747204, EBI-1383632;
CC Q9UKT9; O75771: RAD51D; NbExp=11; IntAct=EBI-747204, EBI-1055693;
CC Q9UKT9; Q9P2K3: RCOR3; NbExp=4; IntAct=EBI-747204, EBI-743428;
CC Q9UKT9; P61586: RHOA; NbExp=3; IntAct=EBI-747204, EBI-446668;
CC Q9UKT9; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-747204, EBI-16428950;
CC Q9UKT9; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-747204, EBI-748391;
CC Q9UKT9; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-747204, EBI-358489;
CC Q9UKT9; Q9NZD8: SPG21; NbExp=6; IntAct=EBI-747204, EBI-742688;
CC Q9UKT9; Q96FJ0: STAMBPL1; NbExp=3; IntAct=EBI-747204, EBI-745021;
CC Q9UKT9; O75716: STK16; NbExp=3; IntAct=EBI-747204, EBI-749295;
CC Q9UKT9; O75558: STX11; NbExp=3; IntAct=EBI-747204, EBI-714135;
CC Q9UKT9; Q9NU19: TBC1D22B; NbExp=9; IntAct=EBI-747204, EBI-8787464;
CC Q9UKT9; Q9Y4C2: TCAF1; NbExp=5; IntAct=EBI-747204, EBI-750484;
CC Q9UKT9; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-747204, EBI-11974855;
CC Q9UKT9; O15273: TCAP; NbExp=3; IntAct=EBI-747204, EBI-954089;
CC Q9UKT9; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-747204, EBI-11955057;
CC Q9UKT9; Q9BT92: TCHP; NbExp=3; IntAct=EBI-747204, EBI-740781;
CC Q9UKT9; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-747204, EBI-8644516;
CC Q9UKT9; Q8WW24: TEKT4; NbExp=7; IntAct=EBI-747204, EBI-750487;
CC Q9UKT9; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-747204, EBI-11952651;
CC Q9UKT9; Q08117: TLE5; NbExp=3; IntAct=EBI-747204, EBI-717810;
CC Q9UKT9; Q08117-2: TLE5; NbExp=5; IntAct=EBI-747204, EBI-11741437;
CC Q9UKT9; O75865: TRAPPC6A; NbExp=3; IntAct=EBI-747204, EBI-743573;
CC Q9UKT9; O75865-2: TRAPPC6A; NbExp=5; IntAct=EBI-747204, EBI-8451480;
CC Q9UKT9; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-747204, EBI-5235829;
CC Q9UKT9; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-747204, EBI-372432;
CC Q9UKT9; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-747204, EBI-10241197;
CC Q9UKT9; Q96PN8: TSSK3; NbExp=8; IntAct=EBI-747204, EBI-3918381;
CC Q9UKT9; Q5T7W7: TSTD2; NbExp=10; IntAct=EBI-747204, EBI-8994397;
CC Q9UKT9; O75604: USP2; NbExp=3; IntAct=EBI-747204, EBI-743272;
CC Q9UKT9; P61758: VBP1; NbExp=3; IntAct=EBI-747204, EBI-357430;
CC Q9UKT9; P07947: YES1; NbExp=5; IntAct=EBI-747204, EBI-515331;
CC Q9UKT9; A0A0S2Z6H0: ZGPAT; NbExp=3; IntAct=EBI-747204, EBI-16428984;
CC Q9UKT9; Q8N5A5: ZGPAT; NbExp=3; IntAct=EBI-747204, EBI-3439227;
CC Q9UKT9; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-747204, EBI-10183064;
CC Q9UKT9; Q9UBW7: ZMYM2; NbExp=3; IntAct=EBI-747204, EBI-2797576;
CC Q9UKT9; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-747204, EBI-740727;
CC Q9UKT9; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-747204, EBI-6427977;
CC Q9UKT9; P36508: ZNF76; NbExp=3; IntAct=EBI-747204, EBI-7254550;
CC Q9UKT9; PRO_0000449633 [P0DTD1]: rep; Xeno; NbExp=3; IntAct=EBI-747204, EBI-25492395;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10369681}. Cytoplasm
CC {ECO:0000269|PubMed:10369681}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Nucleus
CC {ECO:0000269|PubMed:17646674, ECO:0000269|PubMed:34155405}.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Nucleus
CC {ECO:0000269|PubMed:17646674}.
CC -!- SUBCELLULAR LOCATION: [Isoform 11]: Nucleus
CC {ECO:0000269|PubMed:17646674}.
CC -!- SUBCELLULAR LOCATION: [Isoform 14]: Nucleus
CC {ECO:0000269|PubMed:17646674}. Cytoplasm {ECO:0000269|PubMed:17646674}.
CC -!- SUBCELLULAR LOCATION: [Isoform 12]: Cytoplasm
CC {ECO:0000269|PubMed:17646674}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=16;
CC Name=1; Synonyms=Aio-1;
CC IsoId=Q9UKT9-1; Sequence=Displayed;
CC Name=2; Synonyms=Aio-del4;
CC IsoId=Q9UKT9-2; Sequence=VSP_006840;
CC Name=3; Synonyms=Aio-del5;
CC IsoId=Q9UKT9-3; Sequence=VSP_006842;
CC Name=4; Synonyms=Aio-del6;
CC IsoId=Q9UKT9-4; Sequence=VSP_006844;
CC Name=5; Synonyms=Aio-del4,5;
CC IsoId=Q9UKT9-5; Sequence=VSP_006841;
CC Name=6; Synonyms=Aio-del5,6;
CC IsoId=Q9UKT9-6; Sequence=VSP_006843;
CC Name=7; Synonyms=Aio-del2;
CC IsoId=Q9UKT9-7; Sequence=VSP_041274;
CC Name=8; Synonyms=Aio-del2,5;
CC IsoId=Q9UKT9-8; Sequence=VSP_041274, VSP_006842;
CC Name=9; Synonyms=Aio-del3;
CC IsoId=Q9UKT9-9; Sequence=VSP_041278;
CC Name=10; Synonyms=Aio-del3,4;
CC IsoId=Q9UKT9-10; Sequence=VSP_041277;
CC Name=11; Synonyms=Aio-del3,4,5;
CC IsoId=Q9UKT9-11; Sequence=VSP_041276;
CC Name=12; Synonyms=Aio-del3,4,5,6;
CC IsoId=Q9UKT9-12; Sequence=VSP_041275;
CC Name=13; Synonyms=Aio-del4,5,6;
CC IsoId=Q9UKT9-13; Sequence=VSP_041279;
CC Name=14; Synonyms=Aio-1-5a;
CC IsoId=Q9UKT9-14; Sequence=VSP_041280, VSP_041281;
CC Name=15; Synonyms=Aio-del4-5a;
CC IsoId=Q9UKT9-15; Sequence=VSP_006840, VSP_041280;
CC Name=16;
CC IsoId=Q9UKT9-16; Sequence=VSP_055353;
CC -!- TISSUE SPECIFICITY: Expressed most strongly in peripheral blood
CC leukocytes, the spleen, and the thymus. {ECO:0000269|PubMed:17646674}.
CC -!- INDUCTION: Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-
CC dioxin (TCDD) in activated AHR T-cells. {ECO:0000269|PubMed:20676092}.
CC -!- DOMAIN: C2H2-type 5 and C2H2-type 6 mediate homodimerization and
CC heterodimerization. {ECO:0000269|PubMed:34155405}.
CC -!- PTM: Phosphorylation on tyrosine residues induced by IL2 is required
CC for dissociation from HRAS and nuclear translocation of IKZF3 in T-
CC cells. Phosphorylation on tyrosine residues induced by IL4 is required
CC for dissociation from Bcl-X(L) in T-cells.
CC {ECO:0000269|PubMed:10369681, ECO:0000269|PubMed:11714801}.
CC -!- DISEASE: Immunodeficiency 84 (IMD84) [MIM:619437]: An autosomal
CC recessive immunologic disorder characterized by recurrent sinopulmonary
CC infections from childhood associated with low levels of B cells and
CC impaired early B-cell development. There may also be variable T-cell
CC abnormalities. Patients have increased susceptibility to infection with
CC Epstein-Barr virus and a propensity for the development of lymphoma in
CC adulthood. {ECO:0000269|PubMed:34155405}. Note=The disease is caused by
CC variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
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DR EMBL; AF129512; AAF13493.1; -; mRNA.
DR EMBL; AJ292565; CAC80427.1; -; mRNA.
DR EMBL; AJ292566; CAC80428.1; -; mRNA.
DR EMBL; AJ292567; CAC80429.1; -; mRNA.
DR EMBL; AJ292568; CAC80430.1; -; mRNA.
DR EMBL; AJ292569; CAC80431.1; -; mRNA.
DR EMBL; AY377973; AAR84584.1; -; mRNA.
DR EMBL; AY377975; AAR84586.1; -; mRNA.
DR EMBL; AY377976; AAR84587.1; -; mRNA.
DR EMBL; AY377977; AAR84588.1; -; mRNA.
DR EMBL; AY377978; AAR84589.1; -; mRNA.
DR EMBL; AY377979; AAR84590.1; -; mRNA.
DR EMBL; AY377980; AAR84591.1; -; mRNA.
DR EMBL; AY377981; AAR84592.1; -; mRNA.
DR EMBL; AY377982; AAR84593.1; -; mRNA.
DR EMBL; AK301250; BAG62817.1; -; mRNA.
DR EMBL; AK303495; BAG64529.1; -; mRNA.
DR EMBL; AC079199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471152; EAW60606.1; -; Genomic_DNA.
DR EMBL; BC032707; AAH32707.1; -; mRNA.
DR CCDS; CCDS11346.1; -. [Q9UKT9-1]
DR CCDS; CCDS11347.1; -. [Q9UKT9-2]
DR CCDS; CCDS11348.1; -. [Q9UKT9-3]
DR CCDS; CCDS11349.1; -. [Q9UKT9-4]
DR CCDS; CCDS11350.1; -. [Q9UKT9-5]
DR CCDS; CCDS11351.1; -. [Q9UKT9-6]
DR CCDS; CCDS58539.1; -. [Q9UKT9-8]
DR CCDS; CCDS58540.1; -. [Q9UKT9-7]
DR CCDS; CCDS58541.1; -. [Q9UKT9-12]
DR CCDS; CCDS58542.1; -. [Q9UKT9-11]
DR CCDS; CCDS58543.1; -. [Q9UKT9-10]
DR CCDS; CCDS58544.1; -. [Q9UKT9-9]
DR CCDS; CCDS58545.1; -. [Q9UKT9-13]
DR CCDS; CCDS74055.1; -. [Q9UKT9-16]
DR RefSeq; NP_001244337.1; NM_001257408.1. [Q9UKT9-7]
DR RefSeq; NP_001244338.1; NM_001257409.1. [Q9UKT9-8]
DR RefSeq; NP_001244339.1; NM_001257410.1. [Q9UKT9-9]
DR RefSeq; NP_001244340.1; NM_001257411.1. [Q9UKT9-10]
DR RefSeq; NP_001244341.1; NM_001257412.1. [Q9UKT9-11]
DR RefSeq; NP_001244342.1; NM_001257413.1. [Q9UKT9-12]
DR RefSeq; NP_001244343.1; NM_001257414.1. [Q9UKT9-13]
DR RefSeq; NP_001271443.1; NM_001284514.1. [Q9UKT9-16]
DR RefSeq; NP_001271444.1; NM_001284515.1. [Q9UKT9-16]
DR RefSeq; NP_001271445.1; NM_001284516.1. [Q9UKT9-16]
DR RefSeq; NP_036613.2; NM_012481.4. [Q9UKT9-1]
DR RefSeq; NP_899051.1; NM_183228.2. [Q9UKT9-2]
DR RefSeq; NP_899052.1; NM_183229.2. [Q9UKT9-3]
DR RefSeq; NP_899053.1; NM_183230.2. [Q9UKT9-4]
DR RefSeq; NP_899054.1; NM_183231.2. [Q9UKT9-5]
DR RefSeq; NP_899055.1; NM_183232.2. [Q9UKT9-6]
DR AlphaFoldDB; Q9UKT9; -.
DR SMR; Q9UKT9; -.
DR BioGRID; 116484; 204.
DR DIP; DIP-56975N; -.
DR IntAct; Q9UKT9; 179.
DR MINT; Q9UKT9; -.
DR STRING; 9606.ENSP00000344544; -.
DR ChEMBL; CHEMBL4739707; -.
DR iPTMnet; Q9UKT9; -.
DR PhosphoSitePlus; Q9UKT9; -.
DR BioMuta; IKZF3; -.
DR DMDM; 212276437; -.
DR EPD; Q9UKT9; -.
DR jPOST; Q9UKT9; -.
DR MassIVE; Q9UKT9; -.
DR MaxQB; Q9UKT9; -.
DR PaxDb; Q9UKT9; -.
DR PeptideAtlas; Q9UKT9; -.
DR PRIDE; Q9UKT9; -.
DR ProteomicsDB; 84855; -. [Q9UKT9-1]
DR ProteomicsDB; 84856; -. [Q9UKT9-10]
DR ProteomicsDB; 84857; -. [Q9UKT9-11]
DR ProteomicsDB; 84858; -. [Q9UKT9-12]
DR ProteomicsDB; 84859; -. [Q9UKT9-13]
DR ProteomicsDB; 84860; -. [Q9UKT9-14]
DR ProteomicsDB; 84861; -. [Q9UKT9-15]
DR ProteomicsDB; 84862; -. [Q9UKT9-2]
DR ProteomicsDB; 84863; -. [Q9UKT9-3]
DR ProteomicsDB; 84864; -. [Q9UKT9-4]
DR ProteomicsDB; 84865; -. [Q9UKT9-5]
DR ProteomicsDB; 84866; -. [Q9UKT9-6]
DR ProteomicsDB; 84867; -. [Q9UKT9-7]
DR ProteomicsDB; 84868; -. [Q9UKT9-8]
DR ProteomicsDB; 84869; -. [Q9UKT9-9]
DR Antibodypedia; 4475; 504 antibodies from 39 providers.
DR DNASU; 22806; -.
DR Ensembl; ENST00000293068.9; ENSP00000462791.1; ENSG00000161405.17. [Q9UKT9-14]
DR Ensembl; ENST00000346243.7; ENSP00000341977.3; ENSG00000161405.17. [Q9UKT9-6]
DR Ensembl; ENST00000346872.8; ENSP00000344544.3; ENSG00000161405.17. [Q9UKT9-1]
DR Ensembl; ENST00000350532.7; ENSP00000344471.3; ENSG00000161405.17. [Q9UKT9-4]
DR Ensembl; ENST00000351680.7; ENSP00000345622.3; ENSG00000161405.17. [Q9UKT9-3]
DR Ensembl; ENST00000377944.7; ENSP00000367179.3; ENSG00000161405.17. [Q9UKT9-10]
DR Ensembl; ENST00000377945.7; ENSP00000367180.3; ENSG00000161405.17. [Q9UKT9-13]
DR Ensembl; ENST00000377952.6; ENSP00000367188.2; ENSG00000161405.17. [Q9UKT9-12]
DR Ensembl; ENST00000377958.6; ENSP00000367194.2; ENSG00000161405.17. [Q9UKT9-9]
DR Ensembl; ENST00000394189.6; ENSP00000377741.2; ENSG00000161405.17. [Q9UKT9-11]
DR Ensembl; ENST00000439016.2; ENSP00000403027.2; ENSG00000161405.17. [Q9UKT9-5]
DR Ensembl; ENST00000439167.6; ENSP00000403776.2; ENSG00000161405.17. [Q9UKT9-8]
DR Ensembl; ENST00000467757.5; ENSP00000420463.1; ENSG00000161405.17. [Q9UKT9-2]
DR Ensembl; ENST00000535189.5; ENSP00000438972.1; ENSG00000161405.17. [Q9UKT9-7]
DR Ensembl; ENST00000583368.1; ENSP00000462452.1; ENSG00000161405.17. [Q9UKT9-16]
DR Ensembl; ENST00000623724.3; ENSP00000485515.1; ENSG00000161405.17. [Q9UKT9-16]
DR GeneID; 22806; -.
DR KEGG; hsa:22806; -.
DR MANE-Select; ENST00000346872.8; ENSP00000344544.3; NM_012481.5; NP_036613.2.
DR UCSC; uc002hsu.4; human. [Q9UKT9-1]
DR CTD; 22806; -.
DR DisGeNET; 22806; -.
DR GeneCards; IKZF3; -.
DR HGNC; HGNC:13178; IKZF3.
DR HPA; ENSG00000161405; Group enriched (intestine, lymphoid tissue).
DR MalaCards; IKZF3; -.
DR MIM; 606221; gene.
DR MIM; 619437; phenotype.
DR neXtProt; NX_Q9UKT9; -.
DR OpenTargets; ENSG00000161405; -.
DR Orphanet; 67038; B-cell chronic lymphocytic leukemia.
DR PharmGKB; PA37750; -.
DR VEuPathDB; HostDB:ENSG00000161405; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160462; -.
DR HOGENOM; CLU_025502_4_1_1; -.
DR InParanoid; Q9UKT9; -.
DR OMA; CCNVYEF; -.
DR OrthoDB; 385551at2759; -.
DR PhylomeDB; Q9UKT9; -.
DR TreeFam; TF331189; -.
DR PathwayCommons; Q9UKT9; -.
DR SignaLink; Q9UKT9; -.
DR SIGNOR; Q9UKT9; -.
DR BioGRID-ORCS; 22806; 19 hits in 1099 CRISPR screens.
DR ChiTaRS; IKZF3; human.
DR GeneWiki; IKZF3; -.
DR GenomeRNAi; 22806; -.
DR Pharos; Q9UKT9; Tbio.
DR PRO; PR:Q9UKT9; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9UKT9; protein.
DR Bgee; ENSG00000161405; Expressed in granulocyte and 105 other tissues.
DR ExpressionAtlas; Q9UKT9; baseline and differential.
DR Genevisible; Q9UKT9; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IMP:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0042826; F:histone deacetylase binding; IPI:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IDA:UniProtKB.
DR GO; GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
DR GO; GO:0007498; P:mesoderm development; TAS:ProtInc.
DR GO; GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.
DR GO; GO:0045577; P:regulation of B cell differentiation; ISS:UniProtKB.
DR GO; GO:0030888; P:regulation of B cell proliferation; ISS:UniProtKB.
DR GO; GO:0045619; P:regulation of lymphocyte differentiation; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; B-cell activation; Cytoplasm; Disease variant;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..509
FT /note="Zinc finger protein Aiolos"
FT /id="PRO_0000047090"
FT ZN_FING 118..140
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 146..168
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 174..196
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 202..224
FT /note="C2H2-type 4; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..504
FT /note="C2H2-type 6; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..504
FT /note="Mediates homodimerization and heterodimerization"
FT /evidence="ECO:0000269|PubMed:34155405"
FT COMPBIAS 7..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 22
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O08900"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O08900"
FT MOD_RES 326
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 378
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O08900"
FT CROSSLNK 61
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 73
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 100
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 245
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..247
FT /note="Missing (in isoform 16)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055353"
FT VAR_SEQ 21..54
FT /note="Missing (in isoform 7 and isoform 8)"
FT /evidence="ECO:0000303|PubMed:17646674"
FT /id="VSP_041274"
FT VAR_SEQ 55..275
FT /note="Missing (in isoform 12)"
FT /evidence="ECO:0000303|PubMed:17646674"
FT /id="VSP_041275"
FT VAR_SEQ 55..236
FT /note="Missing (in isoform 11)"
FT /evidence="ECO:0000303|PubMed:17646674"
FT /id="VSP_041276"
FT VAR_SEQ 55..197
FT /note="Missing (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:17646674"
FT /id="VSP_041277"
FT VAR_SEQ 55..141
FT /note="Missing (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:17646674"
FT /id="VSP_041278"
FT VAR_SEQ 142..275
FT /note="Missing (in isoform 13)"
FT /evidence="ECO:0000303|PubMed:17646674"
FT /id="VSP_041279"
FT VAR_SEQ 142..236
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:11745366"
FT /id="VSP_006841"
FT VAR_SEQ 142..197
FT /note="Missing (in isoform 2 and isoform 15)"
FT /evidence="ECO:0000303|PubMed:11745366,
FT ECO:0000303|PubMed:17646674"
FT /id="VSP_006840"
FT VAR_SEQ 198..275
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:11745366"
FT /id="VSP_006843"
FT VAR_SEQ 198..236
FT /note="Missing (in isoform 3 and isoform 8)"
FT /evidence="ECO:0000303|PubMed:11745366,
FT ECO:0000303|PubMed:17646674"
FT /id="VSP_006842"
FT VAR_SEQ 237..275
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11745366"
FT /id="VSP_006844"
FT VAR_SEQ 237..263
FT /note="ASAEARHIKAEMGSERALVLDRLASNV -> GTGWGWVELSHLGIRLQDLNV
FT PWCRLH (in isoform 14 and isoform 15)"
FT /evidence="ECO:0000303|PubMed:17646674"
FT /id="VSP_041280"
FT VAR_SEQ 264..509
FT /note="Missing (in isoform 14)"
FT /evidence="ECO:0000303|PubMed:17646674"
FT /id="VSP_041281"
FT VARIANT 159
FT /note="G -> R (in IMD84; no effect on homodimerization
FT activity; no effect on heterodimerization activity; changed
FT localization; changed DNA-binding transcription activator
FT activity; changed sequence-specific DNA binding; binds
FT novel and non-specific DNA motifs and acts as a dominant
FT negative through its homodimerization and
FT heterodimerization activities)"
FT /evidence="ECO:0000269|PubMed:34155405"
FT /id="VAR_086041"
FT VARIANT 277
FT /note="E -> Q (found in a renal cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064724"
FT CONFLICT 321
FT /note="R -> C (in Ref. 1; AAF13493 and 2; CAC80427/
FT CAC80428/CAC80429/CAC80430/CAC80431)"
FT /evidence="ECO:0000305"
FT CONFLICT 361
FT /note="K -> R (in Ref. 1; AAF13493 and 2; CAC80427/
FT CAC80428/CAC80429/CAC80430/CAC80431)"
FT /evidence="ECO:0000305"
FT CONFLICT 365
FT /note="H -> L (in Ref. 1; AAF13493 and 2; CAC80427/
FT CAC80428/CAC80429/CAC80430/CAC80431)"
FT /evidence="ECO:0000305"
FT CONFLICT 443
FT /note="N -> D (in Ref. 1; AAF13493 and 2; CAC80427/
FT CAC80428/CAC80429/CAC80430/CAC80431)"
FT /evidence="ECO:0000305"
FT CONFLICT 487
FT /note="Y -> D (in Ref. 1; AAF13493 and 2; CAC80427/
FT CAC80428/CAC80429/CAC80430/CAC80431)"
FT /evidence="ECO:0000305"
FT CONFLICT 506
FT /note="A -> S (in Ref. 1; AAF13493 and 2; CAC80427/
FT CAC80428/CAC80429/CAC80430/CAC80431)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 509 AA; 58023 MW; D1BB4A0A9A71B81A CRC64;
MEDIQTNAEL KSTQEQSVPA ESAAVLNDYS LTKSHEMENV DSGEGPANED EDIGDDSMKV
KDEYSERDEN VLKSEPMGNA EEPEIPYSYS REYNEYENIK LERHVVSFDS SRPTSGKMNC
DVCGLSCISF NVLMVHKRSH TGERPFQCNQ CGASFTQKGN LLRHIKLHTG EKPFKCHLCN
YACQRRDALT GHLRTHSVEK PYKCEFCGRS YKQRSSLEEH KERCRTFLQS TDPGDTASAE
ARHIKAEMGS ERALVLDRLA SNVAKRKSSM PQKFIGEKRH CFDVNYNSSY MYEKESELIQ
TRMMDQAINN AISYLGAEAL RPLVQTPPAP TSEMVPVISS MYPIALTRAE MSNGAPQELE
KKSIHLPEKS VPSERGLSPN NSGHDSTDTD SNHEERQNHI YQQNHMVLSR ARNGMPLLKE
VPRSYELLKP PPICPRDSVK VINKEGEVMD VYRCDHCRVL FLDYVMFTIH MGCHGFRDPF
ECNMCGYRSH DRYEFSSHIA RGEHRALLK
