ID   IKZF5_CHICK             Reviewed;         421 AA.
AC   Q5ZLR2;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Zinc finger protein Pegasus;
DE   AltName: Full=Ikaros family zinc finger protein 5;
GN   Name=IKZF5; ORFNames=RCJMB04_5c6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Transcriptional repressor that binds the core 5'GNNTGTNG-3'
CC       DNA consensus sequence. {ECO:0000250|UniProtKB:Q9H5V7}.
CC   -!- SUBUNIT: Probably self-associates. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H5V7}.
CC   -!- MISCELLANEOUS: 'Pegasus' was the winged horse in Greek mythology.
CC   -!- SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; AJ719672; CAG31331.1; -; mRNA.
DR   RefSeq; NP_001026766.1; NM_001031595.1.
DR   AlphaFoldDB; Q5ZLR2; -.
DR   SMR; Q5ZLR2; -.
DR   STRING; 9031.ENSGALP00000042828; -.
DR   PaxDb; Q5ZLR2; -.
DR   Ensembl; ENSGALT00000076257; ENSGALP00000056934; ENSGALG00000032289.
DR   GeneID; 430882; -.
DR   KEGG; gga:430882; -.
DR   CTD; 64376; -.
DR   VEuPathDB; HostDB:geneid_430882; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000155035; -.
DR   HOGENOM; CLU_734778_0_0_1; -.
DR   InParanoid; Q5ZLR2; -.
DR   OMA; THNQRNY; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q5ZLR2; -.
DR   PRO; PR:Q5ZLR2; -.
DR   Proteomes; UP000000539; Chromosome 6.
DR   Bgee; ENSGALG00000032289; Expressed in spermatid and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..421
FT                   /note="Zinc finger protein Pegasus"
FT                   /id="PRO_0000299474"
FT   ZN_FING         82..104
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         110..132
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         138..161
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         366..388
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         394..418
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          35..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        294..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  46943 MW;  D88885A337F2542E CRC64;
     MGEKKPEPLD FVKDFQEYLT QQTHHVNMIS GSVSGDKEAE TLQGAGTEGD QNGLDHPSVE
     VSLDENSGML VDGFERTFDG KLKCRYCNYA SKGTARLIEH IRIHTGEKPH RCHLCPFASA
     YERHLEAHMR SHTGEKPYKC ELCSFRCSDR SNLSHHRRRK HKMVPIKGTR SSLSSKKMWG
     VLQKKTSNLG YSRRALINLS PPSMVVHKPD YLNDFTHEIP NIQTEAYESM TKSSQTSGLP
     RDPQDLMVDN PLNQLSTLAG QLSSLPPENQ NERGCSPDVV TCQDEKPFMM QQPATPAVVS
     SVSASIAQSS SPTSPDPRPA HNQRNYSPVA GPSSDRSAHT STPSISNSQP STPAPTLPVQ
     DPQLLHHCQH CDMYFADNIL YTIHMGCHGF ENPFQCNICG CKCKNKYDFA CHFARGQHSQ
     H