IKZF5_DANRE
ID IKZF5_DANRE Reviewed; 419 AA.
AC Q6DBW0; Q6TLH4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Zinc finger protein Pegasus;
DE AltName: Full=Ikaros family zinc finger protein 5;
GN Name=ikzf5; ORFNames=zgc:92405;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor that binds the core 5'GNNTGTNG-3'
CC DNA consensus sequence (By similarity). {ECO:0000250|UniProtKB:Q9H5V7}.
CC -!- SUBUNIT: Probably self-associates. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H5V7}.
CC -!- MISCELLANEOUS: 'Pegasus' was the winged horse in Greek mythology.
CC -!- SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family.
CC {ECO:0000305}.
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DR EMBL; AY394931; AAQ94558.1; -; mRNA.
DR EMBL; BC078341; AAH78341.1; -; mRNA.
DR RefSeq; NP_991164.1; NM_205601.1.
DR RefSeq; XP_009291296.1; XM_009293021.2.
DR AlphaFoldDB; Q6DBW0; -.
DR SMR; Q6DBW0; -.
DR STRING; 7955.ENSDARP00000073468; -.
DR PaxDb; Q6DBW0; -.
DR Ensembl; ENSDART00000079011; ENSDARP00000073468; ENSDARG00000056491.
DR Ensembl; ENSDART00000125335; ENSDARP00000109784; ENSDARG00000056491.
DR Ensembl; ENSDART00000179851; ENSDARP00000149129; ENSDARG00000116693.
DR Ensembl; ENSDART00000189387; ENSDARP00000147344; ENSDARG00000056491.
DR Ensembl; ENSDART00000190425; ENSDARP00000146647; ENSDARG00000056491.
DR GeneID; 402893; -.
DR KEGG; dre:402893; -.
DR CTD; 64376; -.
DR ZFIN; ZDB-GENE-040801-209; ikzf5.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000155035; -.
DR HOGENOM; CLU_734778_0_0_1; -.
DR InParanoid; Q6DBW0; -.
DR OMA; VTASMTH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6DBW0; -.
DR TreeFam; TF331860; -.
DR PRO; PR:Q6DBW0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 17.
DR Bgee; ENSDARG00000056491; Expressed in cleaving embryo and 26 other tissues.
DR ExpressionAtlas; Q6DBW0; baseline.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0071908; P:determination of intestine left/right asymmetry; IMP:ZFIN.
DR GO; GO:0003140; P:determination of left/right asymmetry in lateral mesoderm; IMP:ZFIN.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
DR GO; GO:0035469; P:determination of pancreatic left/right asymmetry; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..419
FT /note="Zinc finger protein Pegasus"
FT /id="PRO_0000299475"
FT ZN_FING 79..101
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 107..129
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 135..158
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 366..388
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 394..418
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 203..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 187
FT /note="G -> S (in Ref. 1; AAQ94558)"
FT /evidence="ECO:0000305"
FT CONFLICT 211
FT /note="H -> Q (in Ref. 1; AAQ94558)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="P -> T (in Ref. 1; AAQ94558)"
FT /evidence="ECO:0000305"
FT CONFLICT 326
FT /note="P -> T (in Ref. 1; AAQ94558)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 419 AA; 46155 MW; 14CBA86FD8E28972 CRC64;
MGEEKPEPLD FVKDFQEYLS QQTQHVNMIS GSVIGVKDSD DLQGELAQNG LEHPAVDMSL
EDSSGMLVDG FERTYDGKLK CRYCNYATRG TARLIEHIRI HTGEKPHRCH LCPFASAYER
HLEAHMRSHT GEKPYKCELC SFRCSDRSNL SHHRRRRHKL LPMKGARSAL SHRKMLSVLQ
KRGNSLGYGR RLLINLSPPS MVLQKPSSEQ HHLGDFTHDL PPHAHLHQEA YNGLGKDPQA
IGGAIGSGSR EDQDMALDNP LNQLSTLAGQ LASIPSEAEG APVSPGAESL PDEKPTFLVQ
QPVTAPAAVS VNTAQASSPI TPEPRPAAHS GCSPGVGPCS ERTSTPSGTN SQPGTPTPVQ
DPQMLHHCPH CHIYFPDNIL YTIHMGCHGY ENPFQCNICG HRCRNSYDFA CHFARGQHK
