ID   IKZF5_XENLA             Reviewed;         453 AA.
AC   Q6NRM0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Zinc finger protein Pegasus;
DE   AltName: Full=Ikaros family zinc finger protein 5;
GN   Name=ikzf5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that binds the core 5'GNNTGTNG-3'
CC       DNA consensus sequence. {ECO:0000250|UniProtKB:Q9H5V7}.
CC   -!- SUBUNIT: Probably self-associates. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H5V7}.
CC   -!- MISCELLANEOUS: 'Pegasus' was the winged horse in Greek mythology.
CC   -!- SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; BC070727; AAH70727.1; -; mRNA.
DR   RefSeq; NP_001084918.1; NM_001091449.1.
DR   AlphaFoldDB; Q6NRM0; -.
DR   DNASU; 431970; -.
DR   GeneID; 431970; -.
DR   KEGG; xla:431970; -.
DR   CTD; 431970; -.
DR   Xenbase; XB-GENE-978537; ikzf5.L.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 431970; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..453
FT                   /note="Zinc finger protein Pegasus"
FT                   /id="PRO_0000299476"
FT   ZN_FING         101..123
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         129..151
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         157..180
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         383..405
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         411..438
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          279..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..371
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  49967 MW;  437F22934F7D9F39 CRC64;
     MGEKKPETLD FVKDFQEYLT QQTHHVNMIS GSVSSDKEAE TLQGGTQNHD ALSANSPCLA
     LPAAATDSDQ NGLDHPSVEV SLDESAGMLV DGFERTFDGK LKCRYCNYAS KGTARLIEHI
     RIHTGEKPHR CHLCPFASAY ERHLEAHMRS HTGEKPYKCE LCSFRCSDRS NLSHHRRRKH
     KMLPIKGTRP SLGNKKMWGV LQKKVSSLGY TRRTLINLSP PSMVVHKADY LSDFAHEIPS
     IQSEAYEHLA KASHSVGLSR DPQELMVDNP LNQLSTLAGQ LSSLPPDTQN PASPDTGPCP
     DEKPFMIQQP PPPACSSAVS TSVAQSSSPA SPEGRPSHNH RNCSPMAGPS SERSGRTSTP
     SISNSQPSTP APALPVQDPQ LLHHCQHCDM YFADNILYTI HMGCHGFENP FQCNICGCKC
     KNKYDFACHF ARGACCQHSS RCAFRRTDDH VTK