ID   IKZF5_XENTR             Reviewed;         434 AA.
AC   A0JPB4; Q28DX8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Zinc finger protein Pegasus;
DE   AltName: Full=Ikaros family zinc finger protein 5;
GN   Name=ikzf5; ORFNames=TEgg054g02.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that binds the core 5'GNNTGTNG-3'
CC       DNA consensus sequence (By similarity). {ECO:0000250|UniProtKB:Q9H5V7}.
CC   -!- SUBUNIT: Probably self-associates. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H5V7}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A0JPB4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A0JPB4-2; Sequence=VSP_027695, VSP_027696;
CC   -!- MISCELLANEOUS: 'Pegasus' was the winged horse in Greek mythology.
CC   -!- SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family.
CC       {ECO:0000305}.
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DR   EMBL; CR848546; CAJ81303.1; -; mRNA.
DR   EMBL; BC127339; AAI27340.1; -; mRNA.
DR   RefSeq; NP_001017355.1; NM_001017355.2.
DR   RefSeq; XP_012822119.1; XM_012966665.2. [A0JPB4-1]
DR   AlphaFoldDB; A0JPB4; -.
DR   PaxDb; A0JPB4; -.
DR   GeneID; 550109; -.
DR   KEGG; xtr:550109; -.
DR   CTD; 64376; -.
DR   Xenbase; XB-GENE-978531; ikzf5.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_734778_0_0_1; -.
DR   InParanoid; A0JPB4; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009559; Expressed in 2-cell stage embryo and 12 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..434
FT                   /note="Zinc finger protein Pegasus"
FT                   /id="PRO_0000299477"
FT   ZN_FING         82..104
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         110..132
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         138..161
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         364..386
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         392..419
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          33..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          260..357
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         44
FT                   /note="G -> GGTQNHDALSANSPCLALPA (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1, ECO:0000303|Ref.2"
FT                   /id="VSP_027695"
FT   VAR_SEQ         415..434
FT                   /note="ACCQHASRCAFRRTDDHVAK -> ARGQHTQH (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1, ECO:0000303|Ref.2"
FT                   /id="VSP_027696"
SQ   SEQUENCE   434 AA;  47991 MW;  3E57D6F82F4D3B85 CRC64;
     MGEKKPETLD FVKDFQEYLT QQTHHVNMIS GSVSSDKEAE TLQGAGTDSD QNGLDHPSVE
     VSLDESAGML VDGFERTFDG KLKCRYCNYA SKGTARLIEH IRIHTGEKPH RCHLCPFASA
     YERHLEAHMR SHTGEKPYKC ELCSFRCSDR SNLSHHRRRK HKMLPIKGTR PSLGNKKMWG
     VLQKKVSSLG YTRRTLINLS PPSMVVHKPD YLSDFAHEIP SIQSEAYESL AKASHSGVLS
     RDPQELMVDN PLNQLSTLAG QLSSLPPDTQ NPASPDTGPC PDEKPFMIQQ PPPPACASAV
     STSVAQSSSP ASPEGRPTHN HRNCSPMAGP SSERSGRTST PSISNSQPST PAPALPAQDP
     QLLHHCQHCD MYFADNILYT IHMGCHGFEN PFQCNICGCK CKNKYDFACH FARGACCQHA
     SRCAFRRTDD HVAK