IKZF_OIKDI
ID IKZF_OIKDI Reviewed; 562 AA.
AC Q6XDT4; Q8WS46;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Ikaros family zinc finger protein;
DE AltName: Full=Ikaros-like transcription factor {ECO:0000312|EMBL:AAP84656.1};
DE Short=OIL {ECO:0000303|PubMed:14634112};
OS Oikopleura dioica (Tunicate).
OC Eukaryota; Metazoa; Chordata; Tunicata; Appendicularia; Copelata;
OC Oikopleuridae; Oikopleura.
OX NCBI_TaxID=34765;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAP84655.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND DOMAIN.
RX PubMed=14634112; DOI=10.4049/jimmunol.171.11.6006;
RA Cupit P.M., Hansen J.D., McCarty A.S., White G., Chioda M., Spada F.,
RA Smale S.T., Cunningham C.;
RT "Ikaros family members from the agnathan Myxine glutinosa and the
RT urochordate Oikopleura dioica: emergence of an essential transcription
RT factor for adaptive immunity.";
RL J. Immunol. 171:6006-6013(2003).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAL56415.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-562.
RX PubMed=11752568; DOI=10.1126/science.294.5551.2506;
RA Seo H.C., Kube M., Edvardsen R.B., Jensen M.F., Beck A., Spriet E.,
RA Gorsky G., Thompson E.M., Lehrach R., Reinhardt H., Chourrout D.;
RT "Miniature genome in the marine chordate Oikopleura dioica.";
RL Science 294:2506-2506(2001).
RN [3]
RP ERRATUM OF PUBMED:11752568.
RA Seo H.C., Kube M., Edvardsen R.B., Jensen M.F., Beck A., Spriet E.,
RA Gorsky G., Thompson E.M., Lehrach R., Reinhardt H., Chourrout D.;
RL Science 295:45-45(2002).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H2S9}.
CC -!- TISSUE SPECIFICITY: Expression is strongest in the anterior Fol cells
CC of the oikoplastic epithelium. {ECO:0000269|PubMed:14634112}.
CC -!- DEVELOPMENTAL STAGE: Very weak expression observed in the oocyte.
CC Strongest expression seen in early tadpole (2 hours posthatching) and
CC at 4/5 days posthatching. {ECO:0000269|PubMed:14634112}.
CC -!- DOMAIN: N-terminal zinc-finger domains are similar to the Ikaros clan
CC but may not have the same binding specificity. Key residues involved in
CC binding to the consensus Ikaros target site (5'-GGGA-3'), found in the
CC promoter regions have diverged. {ECO:0000269|PubMed:14634112}.
CC -!- SIMILARITY: Belongs to the Ikaros C2H2-type zinc-finger protein family.
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL56415.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY237106; AAP84655.1; -; mRNA.
DR EMBL; AY237107; AAP84656.1; -; Genomic_DNA.
DR EMBL; AF374374; AAL56415.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q6XDT4; -.
DR PRIDE; Q6XDT4; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..562
FT /note="Ikaros family zinc finger protein"
FT /id="PRO_0000390937"
FT ZN_FING 45..67
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 73..95
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 101..123
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 129..152
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 494..516
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 522..546
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 178..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 396
FT /note="L -> P (in Ref. 2; AAL56415)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 562 AA; 62620 MW; EF49BB4AC72D5F89 CRC64;
MSENGSVDEI KVEEFNNEAG QTVESGELSE DNELNRKTGR NLNLIKCEEC GLICAGQSHY
NVHIRSHTGE RPFKCHICGV AFTQKGNLRR HYKIHSDEKP FQCPICSYRC RRRDALNGHM
RIHSDMRPYR CSYCARSYKS RQSMKEHEYQ CPYKSDPVQP TPPGSEGFPF QNEAVMRNPL
ALPGPRPSTS QPAPVLSQLG QLGARPPPYP PANINELLAL RARLMAPGAQ HAPPPPQIRP
GLPGFFGNAI PQMPPTTLQQ PFNAESHRSA VGMGGTHALA LHIRRLLANA VQQNQQPGGL
RNSLEKPSLS EATPSSHSSH SSAEDSGQVN KFSPTESKVK PTDINQNVAK ILANMVQPHP
QLEDVPLPDS RKRPHSFESE PTPKRMRSPN PTNLNLDDSH KEDDVITSES PLEITNERKT
FFPHVDAAER TVEAIEDNDE DDVDISVEQL DESKNEISSV DSRSPLDQSS TQDDRMEIKA
QISVFKNGAK LNSWECKTCN CIFLNEITYR IHMGVHMHSD PLVCNSCGKR CSDQQEFQAH
LVHHQHVSKT VVTAPPKATN VV
