ID   IL10H_EBVA8             Reviewed;         170 AA.
AC   P0C6Z6; Q777H2;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Viral interleukin-10 homolog;
DE            Short=vIL-10;
DE   AltName: Full=20 kDa protein;
DE   AltName: Full=Protein BCRF1;
DE   Flags: Precursor;
GN   ORFNames=BCRF1;
OS   Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=82830;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16490228; DOI=10.1016/j.virol.2006.01.015;
RA   Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.;
RT   "The genome of Epstein-Barr virus type 2 strain AG876.";
RL   Virology 350:164-170(2006).
CC   -!- FUNCTION: Inhibits IFN-gamma synthesis. Down-regulates the expression
CC       of the host TAP1 gene (transporter associated with antigen processing),
CC       thereby affecting the transport of peptides into the endoplasmic
CC       reticulum and subsequent peptide loading by MHC class I molecules. In
CC       consequence, infected cells are masked for immune recognition by
CC       cytotoxic T-lymphocytes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
CC   -!- CAUTION: Be careful of the possible confusion between BCRF1 with BcRF1.
CC       {ECO:0000305}.
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DR   EMBL; DQ279927; ABB89220.1; -; Genomic_DNA.
DR   RefSeq; YP_001129439.1; NC_009334.1.
DR   RefSeq; YP_401634.1; NC_007605.1.
DR   SMR; P0C6Z6; -.
DR   IntAct; P0C6Z6; 5.
DR   MINT; P0C6Z6; -.
DR   PRIDE; P0C6Z6; -.
DR   DNASU; 3783689; -.
DR   GeneID; 3783689; -.
DR   GeneID; 5176163; -.
DR   KEGG; vg:3783689; -.
DR   KEGG; vg:5176163; -.
DR   Proteomes; UP000007639; Genome.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0001817; P:regulation of cytokine production; IEA:UniProt.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000098; IL-10.
DR   InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR   InterPro; IPR020423; IL-10_CS.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01294; INTRLEUKIN10.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytokine; Disulfide bond;
KW   Evasion of host immunity by viral interleukin-like protein; Glycoprotein;
KW   Host-virus interaction; Reference proteome; Secreted; Signal;
KW   Viral immunoevasion.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..170
FT                   /note="Viral interleukin-10 homolog"
FT                   /id="PRO_0000375955"
FT   COILED          97..145
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..119
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..125
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   170 AA;  19914 MW;  AE20AE65D358F0CE CRC64;
     MERRLVVTLQ CLVLLYLAPE CGGTDQCDNF PQMLRDLRDA FSRVKTFFQT KDEVDNLLLK
     ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPEAKD HVNSLGENLK TLRLRLRRCH
     RFLPCENKSK AVEQIKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTIKAR