ID   IL10H_EHV2T             Reviewed;         179 AA.
AC   P68677; Q89451;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Viral interleukin-10 homolog;
DE            Short=vIL-10;
DE   Flags: Precursor;
GN   ORFNames=E7;
OS   Equine herpesvirus 2 (strain T400/3) (EHV-2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Percavirus.
OX   NCBI_TaxID=82832;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8385838; DOI=10.1007/bf01702353;
RA   Rode H.J., Janssen W., Rosen-Wolff A., Bugert J.J., Thein P., Becker Y.,
RA   Darai G.;
RT   "The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL10)-
RT   like gene.";
RL   Virus Genes 7:111-116(1993).
CC   -!- FUNCTION: Down-regulates the expression of the TAP1 gene (transporter
CC       associated with antigen processing), thereby affecting the transport of
CC       peptides into the endoplasmic reticulum and subsequent peptide loading
CC       by MHC class I molecules. In consequence, infected cells are masked for
CC       immune recognition by cytotoxic T-lymphocytes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
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DR   EMBL; L08504; AAA46090.1; -; Genomic_DNA.
DR   EMBL; S59624; AAB26148.1; -; Genomic_DNA.
DR   PIR; A48558; A48558.
DR   RefSeq; NP_042666.1; NC_001650.2.
DR   SMR; P68677; -.
DR   GeneID; 1461021; -.
DR   KEGG; vg:1461021; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0001817; P:regulation of cytokine production; IEA:UniProt.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000098; IL-10.
DR   InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR   InterPro; IPR020423; IL-10_CS.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01294; INTRLEUKIN10.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   3: Inferred from homology;
KW   Cytokine; Disulfide bond;
KW   Evasion of host immunity by viral interleukin-like protein; Glycoprotein;
KW   Host-virus interaction; Secreted; Signal; Viral immunoevasion.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..179
FT                   /note="Viral interleukin-10 homolog"
FT                   /id="PRO_0000015377"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        135
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        30..127
FT                   /evidence="ECO:0000250"
FT   DISULFID        80..133
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   179 AA;  20655 MW;  F6516398F67B41F5 CRC64;
     MFRASLLCCL VLLAGVWADN KYDSESGDDC PTLPTSLPHM LHELRAAFSR VKTFFQMKDQ
     LDNMLLDGSL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN HSTDQEKDKV NSLGEKLKTL
     RVRLRRCHRF LPCENKSKAV EQVKSAFSKL QEKGVYKAMS EFDIFINYIE AYMTTKMKN