IL10H_HCMVM
ID IL10H_HCMVM Reviewed; 176 AA.
AC F5HC71;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 23-FEB-2022, entry version 45.
DE RecName: Full=Viral interleukin-10 homolog;
DE Short=cmvIL-10;
DE Short=vIL-10;
DE Flags: Precursor;
GN Name=UL111A;
OS Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX NCBI_TaxID=295027;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Merlin;
RX PubMed=12692276; DOI=10.1099/vir.0.18952-0;
RA Akter P., Cunningham C., McSharry B.P., Dolan A., Addison C., Dargan D.J.,
RA Hassan-Walker A.F., Emery V.C., Griffiths P.D., Wilkinson G.W.,
RA Davison A.J.;
RT "Two novel spliced genes in human cytomegalovirus.";
RL J. Gen. Virol. 84:1117-1122(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT "Genetic content of wild-type human cytomegalovirus.";
RL J. Gen. Virol. 85:1301-1312(2004).
CC -!- FUNCTION: Functional viral IL-10 homolog. Can bind to the human IL-10
CC receptor and compete with human IL-10 for binding sites. Requires both
CC subunits of the human IL-10 receptor complex to induce signal
CC transduction events and biological activities. IL-10 signaling pathway
CC has several immunosuppressive activities that are exploited by the
CC virus. Inhibits TLR-induced type I interferon production in host
CC plasmacytoid dendritic cells (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
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DR EMBL; AY446894; AAR31656.1; -; Genomic_DNA.
DR RefSeq; YP_081552.1; NC_006273.2.
DR SMR; F5HC71; -.
DR PRIDE; F5HC71; -.
DR GeneID; 3077506; -.
DR KEGG; vg:3077506; -.
DR Reactome; R-HSA-9609690; HCMV Early Events.
DR Reactome; R-HSA-9610379; HCMV Late Events.
DR Proteomes; UP000000938; Genome.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0039673; P:evasion by virus of host dendritic cell activity; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.10; -; 1.
DR Gene3D; 4.10.340.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR012352; IL-10_add_hlx.
DR InterPro; IPR020423; IL-10_CS.
DR Pfam; PF00726; IL10; 1.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 3: Inferred from homology;
KW Cytokine; Disulfide bond;
KW Evasion of host immunity by viral interleukin-like protein; Glycoprotein;
KW Host-virus interaction; Inhibition of host innate immune response by virus;
KW Inhibition of host interferon signaling pathway by virus;
KW Modulation of host dendritic cell activity by virus; Reference proteome;
KW Secreted; Signal; Viral immunoevasion.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..176
FT /note="Viral interleukin-10 homolog"
FT /id="PRO_0000416438"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
FT DISULFID 38..128
FT /evidence="ECO:0000250"
FT DISULFID 79
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 82..133
FT /evidence="ECO:0000250"
SQ SEQUENCE 176 AA; 20108 MW; DAC25EBFDFA9A872 CRC64;
MLSVMVSSSL VLIVFFLGAS EEAKPATTTT IKNTKPQCRP EDYATRLQDL RVTFHRVKPT
LQREDDYSVW LDGTVVKGCW GCSVMDWLLR RYLEIVFPAG DHVYPGLKTE LHSMRSTLES
IYKDMRQCPL LGCGDKSVIS RLSQEAERKS DNGTRKGLSE LDTLFSRLEE YLHSRK
