ID   IL11_MACFA              Reviewed;         199 AA.
AC   P20808;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Interleukin-11;
DE            Short=IL-11;
DE   Flags: Precursor;
GN   Name=IL11;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2145578; DOI=10.1073/pnas.87.19.7512;
RA   Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R.,
RA   O'Hara R.M. Jr., Leary A.C., Sibley B.S., Clark S.C., Williams D.A.,
RA   Yang Y.-C.;
RT   "Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-
RT   derived lymphopoietic and hematopoietic cytokine.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:7512-7516(1990).
CC   -!- FUNCTION: Cytokine that stimulates the proliferation of hematopoietic
CC       stem cells and megakaryocyte progenitor cells and induces megakaryocyte
CC       maturation resulting in increased platelet production. Also promotes
CC       the proliferation of hepatocytes in response to liver damage. Binding
CC       to its receptor formed by IL6ST and IL11RA activates a signaling
CC       cascade that promotes cell proliferation. Signaling leads to the
CC       activation of intracellular protein kinases and the phosphorylation of
CC       STAT3. The interaction with the membrane-bound IL11RA and IL6ST
CC       stimulates 'classic signaling', whereas the binding of IL11 and soluble
CC       IL11RA to IL6ST stimulates 'trans-signaling'.
CC       {ECO:0000250|UniProtKB:P20809, ECO:0000250|UniProtKB:P47873}.
CC   -!- SUBUNIT: Interacts with IL11RA to associate with IL6ST, giving rise to
CC       a multimeric signaling complex. {ECO:0000250|UniProtKB:P20809}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P47873}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; M57766; AAA63281.1; -; mRNA.
DR   PIR; A38285; A38285.
DR   RefSeq; XP_005595839.2; XM_005595782.2.
DR   RefSeq; XP_015300293.1; XM_015444807.1.
DR   AlphaFoldDB; P20808; -.
DR   SMR; P20808; -.
DR   STRING; 9541.XP_005595912.1; -.
DR   GeneID; 102118349; -.
DR   GeneID; 102128313; -.
DR   CTD; 3589; -.
DR   eggNOG; ENOG502RZVA; Eukaryota.
DR   OrthoDB; 1469507at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020438; IL-11.
DR   InterPro; IPR020412; IL-11_mml.
DR   PANTHER; PTHR16922; PTHR16922; 1.
DR   Pfam; PF07400; IL11; 1.
DR   PRINTS; PR01943; INTLKN11MAML.
DR   PRINTS; PR01927; INTRLEUKIN11.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..199
FT                   /note="Interleukin-11"
FT                   /id="PRO_0000015619"
FT   REGION          182..190
FT                   /note="Important for interaction with IL11RA and for the
FT                   stimulation of cell proliferation"
FT                   /evidence="ECO:0000250|UniProtKB:P20809"
FT   SITE            168
FT                   /note="Important for interaction with IL6ST and for the
FT                   stimulation of cell proliferation"
FT                   /evidence="ECO:0000250|UniProtKB:P47873"
SQ   SEQUENCE   199 AA;  21674 MW;  D27B1098DA738559 CRC64;
     MNCVCRLVLV VLSLWPDTAV APGPPPGSPR ASPDPRAELD STVLLTRSLL EDTRQLTIQL
     KDKFPADGDH NLDSLPTLAM SAGALGALQL PSVLTRLRAD LLSYLRHVQW LRRAMGSSLK
     TLEPELGTLQ TRLDRLLRRL QLLMSRLALP QLPPDPPAPP LAPPSSTWGG IRAAHAILGG
     LHLTLDWAVR GLLLLKTRL