ID   IL11_RAT                Reviewed;         199 AA.
AC   Q99MF5;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Interleukin-11 {ECO:0000305};
DE            Short=IL-11;
DE   Flags: Precursor;
GN   Name=Il11 {ECO:0000312|RGD:621475};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=11570967; DOI=10.1530/rep.0.1220593;
RA   Li R., Hartley L., Robb L.;
RT   "Cloning of rat interleukin 11 and interleukin 11 receptor alpha chain and
RT   analysis of their expression in rat uterus in the peri-implantation
RT   period.";
RL   Reproduction 122:593-600(2001).
CC   -!- FUNCTION: Cytokine that stimulates the proliferation of hematopoietic
CC       stem cells and megakaryocyte progenitor cells and induces megakaryocyte
CC       maturation resulting in increased platelet production. Also promotes
CC       the proliferation of hepatocytes in response to liver damage. Binding
CC       to its receptor formed by IL6ST and IL11RA activates a signaling
CC       cascade that promotes cell proliferation. Signaling leads to the
CC       activation of intracellular protein kinases and the phosphorylation of
CC       STAT3. The interaction with the membrane-bound IL11RA and IL6ST
CC       stimulates 'classic signaling', whereas the binding of IL11 and soluble
CC       IL11RA to IL6ST stimulates 'trans-signaling'.
CC       {ECO:0000250|UniProtKB:P20809, ECO:0000250|UniProtKB:P47873}.
CC   -!- SUBUNIT: Interacts with IL11RA to associate with IL6ST, giving rise to
CC       a multimeric signaling complex. {ECO:0000250|UniProtKB:P20809}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P47873}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; AF347935; AAK29623.1; -; mRNA.
DR   AlphaFoldDB; Q99MF5; -.
DR   SMR; Q99MF5; -.
DR   STRING; 10116.ENSRNOP00000023489; -.
DR   PaxDb; Q99MF5; -.
DR   PRIDE; Q99MF5; -.
DR   UCSC; RGD:621475; rat.
DR   RGD; 621475; Il11.
DR   eggNOG; ENOG502RZVA; Eukaryota.
DR   InParanoid; Q99MF5; -.
DR   PhylomeDB; Q99MF5; -.
DR   PRO; PR:Q99MF5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; ISO:RGD.
DR   GO; GO:0008083; F:growth factor activity; ISO:RGD.
DR   GO; GO:0005142; F:interleukin-11 receptor binding; ISO:RGD.
DR   GO; GO:0046888; P:negative regulation of hormone secretion; ISO:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:RGD.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020438; IL-11.
DR   InterPro; IPR020412; IL-11_mml.
DR   PANTHER; PTHR16922; PTHR16922; 1.
DR   Pfam; PF07400; IL11; 1.
DR   PRINTS; PR01943; INTLKN11MAML.
DR   PRINTS; PR01927; INTRLEUKIN11.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..199
FT                   /note="Interleukin-11"
FT                   /id="PRO_0000015621"
FT   REGION          182..190
FT                   /note="Important for interaction with IL11RA and for the
FT                   stimulation of cell proliferation"
FT                   /evidence="ECO:0000250|UniProtKB:P20809"
FT   SITE            168
FT                   /note="Important for interaction with IL6ST and for the
FT                   stimulation of cell proliferation"
FT                   /evidence="ECO:0000250|UniProtKB:P47873"
SQ   SEQUENCE   199 AA;  21555 MW;  2AA560DC97A98224 CRC64;
     MNCVCRLVLV VLSLWPDRVV APGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM
     RDKFPADGDH NLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYFRHVQW LRRAAGPSLK
     TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPAVP LGPPASAWGS IRAAHAILGG
     LHLTLDWAVR GLLLLKTRL