IL13_CANLF
ID IL13_CANLF Reviewed; 131 AA.
AC Q9N0W9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Interleukin-13;
DE Short=IL-13;
DE Flags: Precursor;
GN Name=IL13;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11032397; DOI=10.1089/10799900050151049;
RA Yang S., Boroughs K.L., McDermott M.J.;
RT "Canine interleukin-13: molecular cloning of full-length cDNA and
RT expression of biologically active recombinant protein.";
RL J. Interferon Cytokine Res. 20:779-785(2000).
CC -!- FUNCTION: Cytokine that plays important roles in allergic inflammation
CC and immune response to parasite infection. Synergizes with IL2 in
CC regulating interferon-gamma synthesis. Stimulates B-cell proliferation,
CC and activation of eosinophils, basophils, and mast cells (By
CC similarity). Plays an important role in controlling IL33 activity by
CC modulating the production of transmembrane and soluble forms of
CC interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the
CC capacity to antagonize Th1-driven proinflammatory immune response and
CC downregulates synthesis of many proinflammatory cytokines including
CC IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially
CC involves suppression of NF-kappa-B (By similarity). Functions also on
CC nonhematopoietic cells, including endothelial cells where it induces
CC vascular cell adhesion protein 1/VCAM1, which is important in the
CC recruitment of eosinophils. Exerts its biological effects through its
CC receptors which comprises the IL4R chain and the IL13RA1 chain, to
CC activate JAK1 and TYK2, leading to the activation of STAT6. Aside from
CC IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for
CC IL13 and mediates internalization and depletion of extracellular IL13
CC (By similarity). {ECO:0000250|UniProtKB:P20109,
CC ECO:0000250|UniProtKB:P35225, ECO:0000250|UniProtKB:P42203}.
CC -!- SUBUNIT: Interacts with IL13RA2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
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DR EMBL; AF244915; AAF63204.1; -; mRNA.
DR RefSeq; NP_001003384.1; NM_001003384.1.
DR AlphaFoldDB; Q9N0W9; -.
DR SMR; Q9N0W9; -.
DR STRING; 9612.ENSCAFP00000001250; -.
DR PaxDb; Q9N0W9; -.
DR Ensembl; ENSCAFT00030021587; ENSCAFP00030018820; ENSCAFG00030011676.
DR Ensembl; ENSCAFT00845019361; ENSCAFP00845015137; ENSCAFG00845010953.
DR GeneID; 442990; -.
DR KEGG; cfa:442990; -.
DR CTD; 3596; -.
DR VEuPathDB; HostDB:ENSCAFG00845010953; -.
DR eggNOG; ENOG502SZKX; Eukaryota.
DR GeneTree; ENSGT00390000003225; -.
DR InParanoid; Q9N0W9; -.
DR OrthoDB; 1578920at2759; -.
DR Proteomes; UP000002254; Chromosome 11.
DR Bgee; ENSCAFG00000000878; Expressed in jejunum and 5 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
DR GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IEA:Ensembl.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; IEA:Ensembl.
DR GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl.
DR GO; GO:0043306; P:positive regulation of mast cell degranulation; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020470; IL-13.
DR InterPro; IPR001325; IL-4/IL-13.
DR InterPro; IPR018096; IL-4/IL-13_CS.
DR Pfam; PF03487; IL13; 1.
DR PRINTS; PR01929; INTRLEUKIN13.
DR SMART; SM00190; IL4_13; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00838; INTERLEUKIN_4_13; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..131
FT /note="Interleukin-13"
FT /id="PRO_0000247328"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 47..75
FT /evidence="ECO:0000250|UniProtKB:P35225"
FT DISULFID 63..89
FT /evidence="ECO:0000250|UniProtKB:P35225"
SQ SEQUENCE 131 AA; 14268 MW; 9A142B4D0F80370F CRC64;
MALWLTVVIA LTCLGGLASP SPVTPSPTLK ELIEELVNIT QNQASLCNGS MVWSVNLTAG
MYCAALESLI NVSDCSAIQR TQRMLKALCS QKPAAGQISS ERSRDTKIEV IQLVKNLLTY
VRGVYRHGNF R
