ID   IL15_FELCA              Reviewed;         162 AA.
AC   O97687;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Interleukin-15;
DE            Short=IL-15;
DE   Flags: Precursor;
GN   Name=IL15;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lymph node;
RX   PubMed=15598442; DOI=10.1016/j.cyto.2004.09.012;
RA   Dean G.A., Barger A., LaVoy A.;
RT   "Cloning and expression of feline interleukin 15.";
RL   Cytokine 29:77-83(2005).
CC   -!- FUNCTION: Cytokine that stimulates the proliferation of T-lymphocytes.
CC       Stimulation by IL15 requires interaction of IL15 with components of the
CC       IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By
CC       similarity). In neutrophils, stimulates phagocytosis probably by
CC       signaling through the IL15 receptor, composed of the subunits IL15RA,
CC       IL2RB and IL2RG, which results in kinase SYK activation (By
CC       similarity). {ECO:0000250|UniProtKB:P40933}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
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DR   EMBL; AF108148; AAD05268.1; -; mRNA.
DR   RefSeq; NP_001009207.1; NM_001009207.1.
DR   AlphaFoldDB; O97687; -.
DR   SMR; O97687; -.
DR   STRING; 9685.ENSFCAP00000016509; -.
DR   GeneID; 493682; -.
DR   KEGG; fca:493682; -.
DR   CTD; 3600; -.
DR   eggNOG; ENOG502SCMF; Eukaryota.
DR   InParanoid; O97687; -.
DR   OrthoDB; 1521691at2759; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0042119; P:neutrophil activation; ISS:UniProtKB.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.70; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020439; IL-15.
DR   InterPro; IPR003443; IL-15/IL-21_fam.
DR   InterPro; IPR020466; IL-15_mml.
DR   PANTHER; PTHR14356; PTHR14356; 1.
DR   Pfam; PF02372; IL15; 1.
DR   PRINTS; PR01947; INTLKN15MAML.
DR   PRINTS; PR01930; INTRLEUKIN15.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..48
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000015395"
FT   CHAIN           49..162
FT                   /note="Interleukin-15"
FT                   /id="PRO_0000015396"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        83..133
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..136
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   162 AA;  18412 MW;  D8C7CEF7F40110DD CRC64;
     MRILKPYLRS TSIQCYLCLL LNSHFLTEAC IPVFILSCIN AGLPKTEANW QDVISDLKII
     DKIIQSLHID ATLYTESDVH PNCKVTAMKC FLLELHVISL ESKNETIHQT VENIIILANS
     GLSSNRNITE TGCKECEELE EKNIKEFLQS FVHIVQMFIN TS