ID   IL15_MACMU              Reviewed;         162 AA.
AC   P48092;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Interleukin-15;
DE            Short=IL-15;
DE   Flags: Precursor;
GN   Name=IL15;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   PubMed=7561102;
RA   Villinger F.J., Brar S.S., Mayne A.E., Chikkala N., Ansari A.A.;
RT   "Comparative sequence analysis of cytokine genes from human and nonhuman
RT   primates.";
RL   J. Immunol. 155:3946-3954(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Tatsumi M.;
RT   "Molecular cloning and expression of cynomolgus monkey interleukin-15.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine that stimulates the proliferation of T-lymphocytes.
CC       Stimulation by IL15 requires interaction of IL15 with components of the
CC       IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By
CC       similarity). In neutrophils, stimulates phagocytosis probably by
CC       signaling through the IL15 receptor, composed of the subunits IL15RA,
CC       IL2RB and IL2RG, which results in kinase SYK activation (By
CC       similarity). {ECO:0000250|UniProtKB:P40933}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U19843; AAB60398.1; -; mRNA.
DR   EMBL; AB000555; BAA19149.1; -; mRNA.
DR   RefSeq; NP_001038196.1; NM_001044731.1.
DR   RefSeq; XP_014994714.1; XM_015139228.1.
DR   RefSeq; XP_014994715.1; XM_015139229.1.
DR   AlphaFoldDB; P48092; -.
DR   SMR; P48092; -.
DR   STRING; 9544.ENSMMUP00000025100; -.
DR   Ensembl; ENSMMUT00000026825; ENSMMUP00000025100; ENSMMUG00000019092.
DR   GeneID; 699616; -.
DR   KEGG; mcc:699616; -.
DR   CTD; 3600; -.
DR   VEuPathDB; HostDB:ENSMMUG00000019092; -.
DR   VGNC; VGNC:73710; IL15.
DR   eggNOG; ENOG502SCMF; Eukaryota.
DR   GeneTree; ENSGT00390000016264; -.
DR   InParanoid; P48092; -.
DR   OrthoDB; 1521691at2759; -.
DR   Proteomes; UP000006718; Chromosome 5.
DR   Bgee; ENSMMUG00000019092; Expressed in lung and 19 other tissues.
DR   ExpressionAtlas; P48092; baseline.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0042119; P:neutrophil activation; ISS:UniProtKB.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IBA:GO_Central.
DR   GO; GO:0050778; P:positive regulation of immune response; IBA:GO_Central.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   Gene3D; 1.20.1250.70; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020439; IL-15.
DR   InterPro; IPR003443; IL-15/IL-21_fam.
DR   InterPro; IPR020466; IL-15_mml.
DR   PANTHER; PTHR14356; PTHR14356; 1.
DR   Pfam; PF02372; IL15; 1.
DR   PRINTS; PR01947; INTLKN15MAML.
DR   PRINTS; PR01930; INTRLEUKIN15.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..48
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000015397"
FT   CHAIN           49..162
FT                   /note="Interleukin-15"
FT                   /id="PRO_0000015398"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        83..133
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..136
FT                   /evidence="ECO:0000250"
FT   VARIANT         5
FT                   /note="K -> T"
FT   VARIANT         31
FT                   /note="I -> T"
SQ   SEQUENCE   162 AA;  18194 MW;  D233CF7FF6188C01 CRC64;
     MRISKPHLRS VSIQCYLCLL LNSHFLTEAG IHVFILGCFS AGLPKTEANW VNVISDLKKI
     EDLIQSMHID ATLYTESDVH PSCKVTAMKC FLLELQVISH ESGDTDIHDT VENLIILANN
     ILSSNGNITE SGCKECEELE EKNIKEFLQS FVHIVQMFIN TS