ID   IL15_MACTH              Reviewed;         162 AA.
AC   Q4U0U2;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Interleukin-15;
DE            Short=IL-15;
DE   Flags: Precursor;
GN   Name=IL15;
OS   Macaca thibetana (Pere David's macaque) (Tibetan macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=54602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Liang X., Wei K., Zou F.D., Yue B.S.;
RT   "Molecular cloning and characterization of the interleukin 15 (IL15) gene
RT   from Tibetan macaque (Macaca thibetana) and its expression in Escherichia
RT   coli.";
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine that stimulates the proliferation of T-lymphocytes.
CC       Stimulation by IL15 requires interaction of IL15 with components of the
CC       IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By
CC       similarity). In neutrophils, stimulates phagocytosis probably by
CC       signaling through the IL15 receptor, composed of the subunits IL15RA,
CC       IL2RB and IL2RG, which results in kinase SYK activation (By
CC       similarity). {ECO:0000250|UniProtKB:P40933}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
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DR   EMBL; DQ021912; AAY45895.1; -; mRNA.
DR   AlphaFoldDB; Q4U0U2; -.
DR   SMR; Q4U0U2; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0042119; P:neutrophil activation; ISS:UniProtKB.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.70; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020439; IL-15.
DR   InterPro; IPR003443; IL-15/IL-21_fam.
DR   InterPro; IPR020466; IL-15_mml.
DR   PANTHER; PTHR14356; PTHR14356; 1.
DR   Pfam; PF02372; IL15; 1.
DR   PRINTS; PR01947; INTLKN15MAML.
DR   PRINTS; PR01930; INTRLEUKIN15.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..48
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000233185"
FT   CHAIN           49..162
FT                   /note="Interleukin-15"
FT                   /id="PRO_0000233186"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        83..133
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..136
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   162 AA;  18164 MW;  D22FBF7FF6188C01 CRC64;
     MRISKPHLRS VSIQCYLCLL LNSHFLTEAG IHVFILGCFS AGLPKTEANW VNVISDLKKI
     EDLIQSMHID ATLYTESDVH PSCKVTAMKC FLLELQVISH ESGDTDIHDT VENLIILANN
     ILSSNGNITE SGCKECEELE EKNIKEFLQS FVHIVQMFIN AS