IL15_MARHI
ID IL15_MARHI Reviewed; 162 AA.
AC B3F0J0;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 27.
DE RecName: Full=Interleukin-15;
DE Short=IL-15;
DE Flags: Precursor;
GN Name=IL15;
OS Marmota himalayana (Himalayan marmot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Marmota.
OX NCBI_TaxID=93163;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RA Wang B., Tian Y., Meng Z., Yin Y., Li X., Zhang Z., Roggendorf M., Lu M.,
RA Yang D.;
RT "Susceptibility of adult Chinese marmots to woodchuck hepatitis virus
RT infection.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytokine that stimulates the proliferation of T-lymphocytes.
CC Stimulation by IL15 requires interaction of IL15 with components of the
CC IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By
CC similarity). In neutrophils, stimulates phagocytosis probably by
CC signaling through the IL15 receptor, composed of the subunits IL15RA,
CC IL2RB and IL2RG, which results in kinase SYK activation (By
CC similarity). {ECO:0000250|UniProtKB:P40933}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
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DR EMBL; EF414446; ABQ82251.1; -; mRNA.
DR AlphaFoldDB; B3F0J0; -.
DR SMR; B3F0J0; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0042119; P:neutrophil activation; ISS:UniProtKB.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR Gene3D; 1.20.1250.70; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020439; IL-15.
DR InterPro; IPR003443; IL-15/IL-21_fam.
DR InterPro; IPR020466; IL-15_mml.
DR PANTHER; PTHR14356; PTHR14356; 1.
DR Pfam; PF02372; IL15; 1.
DR PRINTS; PR01947; INTLKN15MAML.
DR PRINTS; PR01930; INTRLEUKIN15.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT PROPEP 30..48
FT /evidence="ECO:0000255"
FT /id="PRO_0000358328"
FT CHAIN 49..162
FT /note="Interleukin-15"
FT /id="PRO_0000358329"
FT CARBOHYD 119
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 83..133
FT /evidence="ECO:0000250"
FT DISULFID 90..136
FT /evidence="ECO:0000250"
SQ SEQUENCE 162 AA; 18393 MW; 597C3CA7B0334E1B CRC64;
MRISKPHLRI TSIQCYVCLL LNTHFLTEAG IRVFILGCIS AGIPKTEANW EDVRKDLQKI
ENLIQSLHMD ATLYTESDVH PRCKVTTMNC FLLELEVISH ESRDGDIEET VKNLILLANS
SLSSNGNITE SGCKVCEELE EKNITEFLES FKHIVQMFIN PP
