ID   APLY_APLKU              Reviewed;         556 AA.
AC   Q17043;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Aplysianin-A;
DE   Flags: Precursor;
OS   Aplysia kurodai (Kuroda's sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6501;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 20-44 AND 95-115.
RC   TISSUE=Albumen gland;
RX   PubMed=8549758; DOI=10.1016/0014-5793(95)01375-x;
RA   Takamatsu N., Shiba T., Muramoto K., Kamiya H.;
RT   "Molecular cloning of the defense factor in the albumen gland of the sea
RT   hare Aplysia kurodai.";
RL   FEBS Lett. 377:373-376(1995).
CC   -!- FUNCTION: Has antibacterial activity against Gram-negative and Gram-
CC       positive bacteria.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- TISSUE SPECIFICITY: Albumen gland.
CC   -!- SIMILARITY: To A.fulica achacin protein. {ECO:0000305}.
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DR   EMBL; D83255; BAA11867.1; -; mRNA.
DR   PIR; S68408; S68408.
DR   AlphaFoldDB; Q17043; -.
DR   SMR; Q17043; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Glycoprotein; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:8549758"
FT   CHAIN           20..556
FT                   /note="Aplysianin-A"
FT                   /id="PRO_0000020749"
FT   CARBOHYD        150
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        374
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        399
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        414
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        430
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   556 AA;  62376 MW;  DF9DB3951A005D53 CRC64;
     MAVRFLALGL LIFVTSCSGR RVCESQQSCD DEQCDETLNI AIVGAGPSGA YSAYKMRHSG
     KDVGLFEYCN RVGGRLYTYQ LPNTPDVNLE LGGMRYITGA HNILQEVTKE LGLKSVLFTE
     GFGRPGRTRY FLRGQSLTHE EVQSGDVPYN LTTIEKLNQG RIYEYYLKEL TGFDIGNGSI
     SREQLLKLRV SDGRLLYQLT FDEALDLVAS PEGKEFARDV HVFHTEVTSD ANAVSVFDDH
     LGEDGAGDAI LTVEEGMQKV PKELIKEFKK TSASNQVQLN KYLQAIRSKS DHSFVLYFRP
     TSTVDGKTTI LDYRPLQRVC ARQVILALPV FALRRLDWPP LHEGRAETAY AAVRNMAASK
     VFMTFDQAWW LDRNFTDNTA FVTKGDTPFS QMYDWKKSNV SGDYILIASY ADGNNTLYQK
     VLRDQGESIN GSEPGANRVS EPLKNNILDH LSEAYGVDRS TIPEPKTAVS QFWTDYPFGC
     GWITWRAGYH FDDVMSTMRR PSLKDEVYVV GADYSWGLMS SWTEGALETA DAVLKDYFKG
     ECAKPPSVDH LDSHMA