ID   IL15_PIG                Reviewed;         162 AA.
AC   Q95253; Q195F8;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Interleukin-15;
DE            Short=IL-15;
DE   Flags: Precursor;
GN   Name=IL15;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RX   PubMed=9305780; DOI=10.1016/s0378-1119(97)00188-1;
RA   Canals A., Grimm D.R., Gasbarre L.C., Lunney J.K., Zarlenga D.S.;
RT   "Molecular cloning of cDNA encoding porcine interleukin-15.";
RL   Gene 195:337-339(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zheng L.-L., Cui B.-A., Fang Z.-Y.;
RT   "Cloning and sequencing of porcine IL-15.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine that stimulates the proliferation of T-lymphocytes.
CC       Stimulation by IL15 requires interaction of IL15 with components of the
CC       IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By
CC       similarity). In neutrophils, stimulates phagocytosis probably by
CC       signaling through the IL15 receptor, composed of the subunits IL15RA,
CC       IL2RB and IL2RG, which results in kinase SYK activation (By
CC       similarity). {ECO:0000250|UniProtKB:P40933}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
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DR   EMBL; U58142; AAB72031.1; -; mRNA.
DR   EMBL; DQ658181; ABF82250.1; -; mRNA.
DR   RefSeq; NP_999555.1; NM_214390.1.
DR   AlphaFoldDB; Q95253; -.
DR   SMR; Q95253; -.
DR   STRING; 9823.ENSSSCP00000009657; -.
DR   PaxDb; Q95253; -.
DR   PRIDE; Q95253; -.
DR   GeneID; 397683; -.
DR   KEGG; ssc:397683; -.
DR   CTD; 3600; -.
DR   eggNOG; ENOG502SCMF; Eukaryota.
DR   InParanoid; Q95253; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0042119; P:neutrophil activation; ISS:UniProtKB.
DR   GO; GO:0001819; P:positive regulation of cytokine production; IBA:GO_Central.
DR   GO; GO:0050778; P:positive regulation of immune response; IBA:GO_Central.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR   GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IBA:GO_Central.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IBA:GO_Central.
DR   Gene3D; 1.20.1250.70; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020439; IL-15.
DR   InterPro; IPR003443; IL-15/IL-21_fam.
DR   InterPro; IPR020466; IL-15_mml.
DR   PANTHER; PTHR14356; PTHR14356; 1.
DR   Pfam; PF02372; IL15; 1.
DR   PRINTS; PR01947; INTLKN15MAML.
DR   PRINTS; PR01930; INTRLEUKIN15.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..48
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000015401"
FT   CHAIN           49..162
FT                   /note="Interleukin-15"
FT                   /id="PRO_0000015402"
FT   CARBOHYD        119
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        83..133
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..136
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   162 AA;  18437 MW;  7EF7992391883446 CRC64;
     MRILKPCLRS TCIQCYLCLL LNSHFLTEDG IHVFILGCIS AGLPKTEATW QHVISDLKKI
     EDLIRSIHMD ATLYTESDAH PNCKVTAMKC FLLELRVILQ ESRNSDISDT VENLIILANS
     SLSSIEYKTE SGCKECEELE EKNINEFLKS FIHIVQMFIN PS