IL15_RABIT
ID IL15_RABIT Reviewed; 162 AA.
AC Q3Y5G8;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Interleukin-15;
DE Short=IL-15;
DE Flags: Precursor;
GN Name=IL15;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15978671; DOI=10.1016/j.vetimm.2005.04.013;
RA Xiong C., Hixson P.M., Mendoza L.H., Smith C.W.;
RT "Cloning and expression of rabbit interleukin-15.";
RL Vet. Immunol. Immunopathol. 107:131-141(2005).
CC -!- FUNCTION: Cytokine that stimulates the proliferation of T-lymphocytes.
CC Stimulation by IL15 requires interaction of IL15 with components of the
CC IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By
CC similarity). In neutrophils, stimulates phagocytosis probably by
CC signaling through the IL15 receptor, which results in kinase SYK
CC activation (By similarity). {ECO:0000250|UniProtKB:P40933}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in many tissues including heart, spleen,
CC lung, liver, muscle and kidney (at mRNA level). Expressed in many
CC tissues including heart, spleen, lung, liver, muscle and kidney (at
CC protein level). {ECO:0000269|PubMed:15978671}.
CC -!- SIMILARITY: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
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DR EMBL; DQ157452; AAZ82803.1; -; mRNA.
DR RefSeq; NP_001075685.1; NM_001082216.2.
DR RefSeq; XP_017202736.1; XM_017347247.1.
DR AlphaFoldDB; Q3Y5G8; -.
DR SMR; Q3Y5G8; -.
DR STRING; 9986.ENSOCUP00000007620; -.
DR Ensembl; ENSOCUT00000008824; ENSOCUP00000007620; ENSOCUG00000008827.
DR GeneID; 100009017; -.
DR KEGG; ocu:100009017; -.
DR CTD; 3600; -.
DR eggNOG; ENOG502SCMF; Eukaryota.
DR GeneTree; ENSGT00390000016264; -.
DR HOGENOM; CLU_135111_0_0_1; -.
DR InParanoid; Q3Y5G8; -.
DR OMA; ANWQDVI; -.
DR TreeFam; TF336199; -.
DR Proteomes; UP000001811; Chromosome 15.
DR Bgee; ENSOCUG00000008827; Expressed in heart and 15 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR GO; GO:0048469; P:cell maturation; IEA:Ensembl.
DR GO; GO:0045062; P:extrathymic T cell selection; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0048535; P:lymph node development; IEA:Ensembl.
DR GO; GO:0030225; P:macrophage differentiation; IEA:Ensembl.
DR GO; GO:0001779; P:natural killer cell differentiation; IEA:Ensembl.
DR GO; GO:0001787; P:natural killer cell proliferation; IEA:Ensembl.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0042119; P:neutrophil activation; ISS:UniProtKB.
DR GO; GO:0001866; P:NK T cell proliferation; IEA:Ensembl.
DR GO; GO:0050778; P:positive regulation of immune response; IEA:Ensembl.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR GO; GO:0032825; P:positive regulation of natural killer cell differentiation; IEA:Ensembl.
DR GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR GO; GO:1904100; P:positive regulation of protein O-linked glycosylation; IEA:Ensembl.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0050691; P:regulation of defense response to virus by host; IEA:Ensembl.
DR GO; GO:0045580; P:regulation of T cell differentiation; IEA:Ensembl.
DR GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR Gene3D; 1.20.1250.70; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020439; IL-15.
DR InterPro; IPR003443; IL-15/IL-21_fam.
DR InterPro; IPR020466; IL-15_mml.
DR PANTHER; PTHR14356; PTHR14356; 1.
DR Pfam; PF02372; IL15; 1.
DR PRINTS; PR01947; INTLKN15MAML.
DR PRINTS; PR01930; INTRLEUKIN15.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 1: Evidence at protein level;
KW Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT PROPEP 30..48
FT /evidence="ECO:0000255"
FT /id="PRO_0000043393"
FT CHAIN 49..162
FT /note="Interleukin-15"
FT /id="PRO_0000043394"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 119
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 83..133
FT /evidence="ECO:0000250"
FT DISULFID 90..136
FT /evidence="ECO:0000250"
SQ SEQUENCE 162 AA; 18330 MW; 6F9C7CC129FB64B9 CRC64;
MRISKPYLRS TSIQCYLCLL LNSHFLAEAG IHVFIFGCIS AGLPKTEANW HDVISDLKRI
EDLIKSIHID ATLYTESDAH PNCKVTAMKC FLLELRVISH ESRNMDINET VQNLIILANT
SLSSKGNVTE SGCKECEELE EKNITEFLQS FIHIVQMFIN SP
