IL15_RAT
ID IL15_RAT Reviewed; 162 AA.
AC P97604; O54847;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Interleukin-15;
DE Short=IL-15;
DE Flags: Precursor;
GN Name=Il15;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
RC STRAIN=Sprague-Dawley; TISSUE=Jejunum;
RX PubMed=8942753; DOI=10.1016/s0016-5085(96)70036-7;
RA Reinecker H.C., Macdermott R.P., Mirau S., Dignass A., Podolsky D.K.;
RT "Intestinal epithelial cells both express and respond to interleukin 15.";
RL Gastroenterology 111:1706-1713(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
RC STRAIN=Wistar; TISSUE=Spleen;
RA Park J.-H.;
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytokine that stimulates the proliferation of T-lymphocytes.
CC Stimulation by IL15 requires interaction of IL15 with components of the
CC IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By
CC similarity). In neutrophils, stimulates phagocytosis probably by
CC signaling through the IL15 receptor, composed of the subunits IL15RA,
CC IL2RB and IL2RG, which results in kinase SYK activation (By
CC similarity). {ECO:0000250|UniProtKB:P40933}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=P97604-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=P97604-2; Sequence=VSP_002662;
CC -!- SIMILARITY: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
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DR EMBL; U69272; AAB41697.1; -; mRNA.
DR EMBL; AF015719; AAB94536.1; -; mRNA.
DR EMBL; AF015718; AAB94535.1; -; mRNA.
DR RefSeq; NP_037261.1; NM_013129.2. [P97604-1]
DR RefSeq; XP_008770585.1; XM_008772363.2. [P97604-2]
DR RefSeq; XP_017456674.1; XM_017601185.1. [P97604-1]
DR RefSeq; XP_017456675.1; XM_017601186.1. [P97604-1]
DR RefSeq; XP_017456676.1; XM_017601187.1. [P97604-1]
DR RefSeq; XP_017456677.1; XM_017601188.1. [P97604-1]
DR RefSeq; XP_017456678.1; XM_017601189.1. [P97604-1]
DR AlphaFoldDB; P97604; -.
DR SMR; P97604; -.
DR STRING; 10116.ENSRNOP00000004590; -.
DR GlyGen; P97604; 5 sites.
DR Ensembl; ENSRNOT00000109879; ENSRNOP00000077234; ENSRNOG00000003439. [P97604-1]
DR GeneID; 25670; -.
DR KEGG; rno:25670; -.
DR CTD; 3600; -.
DR RGD; 2887; Il15.
DR eggNOG; ENOG502SCMF; Eukaryota.
DR GeneTree; ENSGT00390000016264; -.
DR HOGENOM; CLU_135111_0_0_1; -.
DR InParanoid; P97604; -.
DR OMA; ANWQDVI; -.
DR OrthoDB; 1876194at2759; -.
DR PhylomeDB; P97604; -.
DR TreeFam; TF336199; -.
DR Reactome; R-RNO-8983432; Interleukin-15 signaling.
DR PRO; PR:P97604; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000003439; Expressed in quadriceps femoris and 20 other tissues.
DR Genevisible; P97604; RN.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005125; F:cytokine activity; ISO:RGD.
DR GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0001525; P:angiogenesis; TAS:RGD.
DR GO; GO:0048469; P:cell maturation; ISO:RGD.
DR GO; GO:0071305; P:cellular response to vitamin D; IEP:RGD.
DR GO; GO:0045062; P:extrathymic T cell selection; ISO:RGD.
DR GO; GO:0030212; P:hyaluronan metabolic process; IDA:RGD.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEP:RGD.
DR GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0048535; P:lymph node development; ISO:RGD.
DR GO; GO:0030225; P:macrophage differentiation; ISO:RGD.
DR GO; GO:0001779; P:natural killer cell differentiation; IEA:Ensembl.
DR GO; GO:0001787; P:natural killer cell proliferation; IEA:Ensembl.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:RGD.
DR GO; GO:0042119; P:neutrophil activation; ISS:UniProtKB.
DR GO; GO:0001866; P:NK T cell proliferation; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
DR GO; GO:0001819; P:positive regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050778; P:positive regulation of immune response; ISO:RGD.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; ISO:RGD.
DR GO; GO:0032825; P:positive regulation of natural killer cell differentiation; ISO:RGD.
DR GO; GO:0032819; P:positive regulation of natural killer cell proliferation; ISO:RGD.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
DR GO; GO:1904100; P:positive regulation of protein O-linked glycosylation; ISO:RGD.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:RGD.
DR GO; GO:0050691; P:regulation of defense response to virus by host; ISO:RGD.
DR GO; GO:0045580; P:regulation of T cell differentiation; ISO:RGD.
DR GO; GO:0031667; P:response to nutrient levels; IEP:RGD.
DR GO; GO:0014732; P:skeletal muscle atrophy; IEP:RGD.
DR GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; ISO:RGD.
DR Gene3D; 1.20.1250.70; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020439; IL-15.
DR InterPro; IPR003443; IL-15/IL-21_fam.
DR InterPro; IPR020466; IL-15_mml.
DR PANTHER; PTHR14356; PTHR14356; 1.
DR Pfam; PF02372; IL15; 1.
DR PRINTS; PR01947; INTLKN15MAML.
DR PRINTS; PR01930; INTRLEUKIN15.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytokine; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT PROPEP 30..48
FT /evidence="ECO:0000255"
FT /id="PRO_0000015403"
FT CHAIN 49..162
FT /note="Interleukin-15"
FT /id="PRO_0000015404"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 119
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 83..133
FT /evidence="ECO:0000250"
FT DISULFID 90..136
FT /evidence="ECO:0000250"
FT VAR_SEQ 81..96
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_002662"
SQ SEQUENCE 162 AA; 18804 MW; DA68097A83065AEA CRC64;
MKILKPYMRN TSILYYLCFL LNSHFLTEAG IHVFILGCVS VGLPKTEANW IDVRYDLEKI
ESLIQFIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH EYSNMTLNET VRNVLYLANS
TLSSNKNVIE SGCKECEELE ERNFTEFLQS FIHIVQMFIN TS
