IL16_BOVIN
ID IL16_BOVIN Reviewed; 627 AA.
AC Q0V8R5;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Pro-interleukin-16;
DE Contains:
DE RecName: Full=Interleukin-16;
DE Short=IL-16;
DE AltName: Full=Lymphocyte chemoattractant factor;
DE Short=LCF;
GN Name=IL16;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- FUNCTION: Interleukin-16 stimulates a migratory response in CD4+
CC lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2
CC and IL-15 responsiveness. Also induces T-lymphocyte expression of
CC interleukin 2 receptor. Ligand for CD4 (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Pro-interleukin-16 is involved in cell cycle progression in
CC T-cells. Appears to be involved in transcriptional regulation of SKP2
CC and is probably part of a transcriptional repression complex on the
CC core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the
CC DNA-binding subunit the GABP transcription factor complex) and HDAC3
CC thus maintaining transcriptional repression and blocking cell cycle
CC progression in resting T-cells (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homotetramer (Probable). Pro-interleukin-16 interacts (via PDZ
CC 2 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Pro-interleukin-16
CC interacts with GRIN2A. Pro-interleukin-16 interacts with GABPB1. Pro-
CC interleukin-16 interacts (via PDZ 3 domain) with HDAC3 (By similarity).
CC {ECO:0000250, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Interleukin-16]: Secreted {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Pro-interleukin-16]: Cytoplasm. Nucleus
CC {ECO:0000250}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BT026153; ABG66992.1; -; mRNA.
DR RefSeq; NP_001068721.1; NM_001075253.1.
DR AlphaFoldDB; Q0V8R5; -.
DR SMR; Q0V8R5; -.
DR STRING; 9913.ENSBTAP00000014556; -.
DR PaxDb; Q0V8R5; -.
DR PRIDE; Q0V8R5; -.
DR Ensembl; ENSBTAT00000014556; ENSBTAP00000014556; ENSBTAG00000010963.
DR GeneID; 506314; -.
DR KEGG; bta:506314; -.
DR CTD; 3603; -.
DR VEuPathDB; HostDB:ENSBTAG00000010963; -.
DR VGNC; VGNC:53943; IL16.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00940000156178; -.
DR HOGENOM; CLU_007677_0_0_1; -.
DR InParanoid; Q0V8R5; -.
DR OrthoDB; 225688at2759; -.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000010963; Expressed in retropharyngeal lymph node and 101 other tissues.
DR ExpressionAtlas; Q0V8R5; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042609; F:CD4 receptor binding; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0050930; P:induction of positive chemotaxis; IBA:GO_Central.
DR GO; GO:0030595; P:leukocyte chemotaxis; IBA:GO_Central.
DR Gene3D; 2.30.42.10; -; 2.
DR InterPro; IPR020450; IL-16.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00595; PDZ; 2.
DR PRINTS; PR01931; INTRLEUKIN16.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; SSF50156; 2.
DR PROSITE; PS50106; PDZ; 2.
PE 2: Evidence at transcript level;
KW Chemotaxis; Cytokine; Cytoplasm; Nucleus; Reference proteome; Repeat;
KW Secreted; Transcription; Transcription regulation.
FT CHAIN 1..627
FT /note="Pro-interleukin-16"
FT /id="PRO_0000377541"
FT CHAIN 508..627
FT /note="Interleukin-16"
FT /evidence="ECO:0000250"
FT /id="PRO_0000274206"
FT DOMAIN 408..493
FT /note="PDZ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 529..614
FT /note="PDZ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 38..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..498
FT /note="Interaction with PPP1R12A, PPP1R12B and PPP1R12C"
FT /evidence="ECO:0000250"
FT COMPBIAS 131..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 66428 MW; 0FF711FEACAA7933 CRC64;
MDYSLETTAE DPWVRISDCI KNLFSPIMSE NHNHVPLQPD APLGEEDGMR GHPDGAAAKL
DTTGGGPKAY KQAGGSTVKK GPPVAPKPAW FRQSLKGLRN RVPDSRREMA ASCQPTPTSR
ERPGPPLRAS SSIKQRISSF ETFSSAHPPD RGAQRLSLQA SSSSGEAAEL PRKQEGERAS
GPSGQGAPPT MEQQRPEPEQ LPPASPATSE ASNPGVSGHP PLEQQPGQKT LSSDPDPLSR
LLATQMEGPR GPVVKMPSQR ARSFPLSRTQ SCEMKPLDEK TSKLYSISSQ VSSAVMKSLL
CLPSSLSFGQ IPCSPKEGVL PPTAFSEDPT NSSAEASASD TSFSLNLSEL REYTEGLSES
TEANDCDHCT SQPGQSVISL LSTEELKKLI EEVKVLDEAT LKQLDSIHVT ILHKEEGAGL
GFSLAGGADL ENKVITVHRV FPNGLASQEG TIQKGNEVLS INGKSLKGAT HNDALAILRQ
AREPRQAVIV TRRPTLEATT DLNSSTDSSG SASVTSDVSI ESAEATVCTV TLEKTSAGLG
FSLEGGKGSL HGDKPLTVNR IFKGLASEQS DTVQPGDEIV HLAGTAMQGL TRFEAWNIIK
ALPDGPVTIV LRRKSLQSKG TPAAGDP
