IL16_MOUSE
ID IL16_MOUSE Reviewed; 1322 AA.
AC O54824; O70236; Q3TEM4; Q5DTR5; Q8R0G5; Q9QZP6;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 3.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Pro-interleukin-16;
DE Contains:
DE RecName: Full=Interleukin-16;
DE Short=IL-16;
DE AltName: Full=Lymphocyte chemoattractant factor;
DE Short=LCF;
GN Name=Il16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY (ISOFORM 2).
RC STRAIN=NFS; TISSUE=Spleen;
RX PubMed=9637508;
RA Keane J., Nicoll J., Kim S., Wu D.M.H., Cruikshank W.W., Brazer W.,
RA Natke B., Zhang Y., Center D.M., Kornfeld H.;
RT "Conservation of structure and function between human and murine IL-16.";
RL J. Immunol. 160:5945-5954(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=9510557; DOI=10.1007/s002510050374;
RA Bannert N., Adler H.S., Werner A., Baier M., Kurth R.;
RT "Molecular cloning and sequence analysis of interleukin 16 from nonhuman
RT primates and from the mouse.";
RL Immunogenetics 47:390-397(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION (ISOFORM 1),
RP TISSUE SPECIFICITY (ISOFORM 1), INTERACTION WITH GRIN2A; GRIN2D; KCNJ10;
RP KCNJ15 AND CACNA1C, AND PROTEOLYTIC PROCESSING.
RX PubMed=10479680; DOI=10.1523/jneurosci.19-18-07770.1999;
RA Kurschner C., Yuzaki M.;
RT "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.";
RL J. Neurosci. 19:7770-7780(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Interleukin-16 stimulates a migratory response in CD4+
CC lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2
CC and IL-15 responsiveness. Also induces T-lymphocyte expression of
CC interleukin 2 receptor. Ligand for CD4.
CC -!- FUNCTION: Isoform 1 may act as a scaffolding protein that anchors ion
CC channels in the membrane.
CC -!- FUNCTION: Isoform 2 is involved in cell cycle progression in T-cells.
CC Appears to be involved in transcriptional regulation of SKP2 and is
CC probably part of a transcriptional repression complex on the core
CC promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-
CC binding subunit the GABP transcription factor complex) and HDAC3 thus
CC maintaining transcriptional repression and blocking cell cycle
CC progression in resting T-cells.
CC -!- SUBUNIT: Homotetramer (Probable). Isoform 2 interacts with GRIN2A.
CC Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C. Isoform 2
CC interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C.
CC Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GABPB1.
CC Isoform 2 interacts (via PDZ 3 domain) with HDAC3 (By similarity).
CC {ECO:0000250, ECO:0000305}.
CC -!- INTERACTION:
CC O54824; Q7TS72: Itpkc; NbExp=3; IntAct=EBI-641708, EBI-648015;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm
CC {ECO:0000269|PubMed:10479680}. Note=Colocalizes with GRIN2C in neuronal
CC cell bodies and neurites.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage; Named isoforms=2;
CC Name=1; Synonyms=NIL-16;
CC IsoId=O54824-1; Sequence=Displayed;
CC Name=2; Synonyms=Pro-IL-16;
CC IsoId=O54824-2; Sequence=VSP_037460;
CC -!- TISSUE SPECIFICITY: Isoform 1 is expressed in neurons of the cerebellum
CC and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.
CC -!- PTM: Synthesized as a chemo-attractant inactive precursor which is
CC proteolytically cleaved by caspase-3 to yield IL-16.
CC {ECO:0000269|PubMed:10479680}.
CC -!- MISCELLANEOUS: [Isoform 1]: Produced by alternative promoter usage. Is
CC probably proteolytically processed to yield IL-16.
CC -!- MISCELLANEOUS: [Isoform 2]: Produced by alternative promoter usage. Is
CC proteolytically processed to yield IL-16. {ECO:0000305}.
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DR EMBL; AF006001; AAC04383.1; -; mRNA.
DR EMBL; AF017111; AAC16039.1; -; mRNA.
DR EMBL; AF175292; AAD55393.1; -; mRNA.
DR EMBL; AK038319; BAC29967.1; -; mRNA.
DR EMBL; AK169551; BAE41224.1; -; mRNA.
DR EMBL; AK220455; BAD90484.1; -; mRNA.
DR EMBL; CH466543; EDL06877.1; -; Genomic_DNA.
DR EMBL; BC026894; AAH26894.1; -; mRNA.
DR EMBL; BC058709; AAH58709.1; -; mRNA.
DR CCDS; CCDS21412.1; -. [O54824-1]
DR CCDS; CCDS90266.1; -. [O54824-2]
DR RefSeq; NP_034681.2; NM_010551.3. [O54824-1]
DR RefSeq; XP_006507449.1; XM_006507386.3. [O54824-1]
DR RefSeq; XP_011239983.1; XM_011241681.2. [O54824-1]
DR AlphaFoldDB; O54824; -.
DR SMR; O54824; -.
DR BioGRID; 200618; 16.
DR ELM; O54824; -.
DR IntAct; O54824; 13.
DR MINT; O54824; -.
DR STRING; 10090.ENSMUSP00000001792; -.
DR iPTMnet; O54824; -.
DR PhosphoSitePlus; O54824; -.
DR EPD; O54824; -.
DR jPOST; O54824; -.
DR MaxQB; O54824; -.
DR PaxDb; O54824; -.
DR PeptideAtlas; O54824; -.
DR PRIDE; O54824; -.
DR ProteomicsDB; 267230; -. [O54824-1]
DR ProteomicsDB; 267231; -. [O54824-2]
DR Antibodypedia; 3932; 765 antibodies from 46 providers.
DR DNASU; 16170; -.
DR Ensembl; ENSMUST00000001792; ENSMUSP00000001792; ENSMUSG00000001741. [O54824-1]
DR Ensembl; ENSMUST00000145610; ENSMUSP00000146496; ENSMUSG00000001741. [O54824-2]
DR GeneID; 16170; -.
DR KEGG; mmu:16170; -.
DR UCSC; uc009idr.1; mouse. [O54824-2]
DR UCSC; uc009ids.1; mouse. [O54824-1]
DR CTD; 3603; -.
DR MGI; MGI:1270855; Il16.
DR VEuPathDB; HostDB:ENSMUSG00000001741; -.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00940000156178; -.
DR HOGENOM; CLU_007677_0_0_1; -.
DR InParanoid; O54824; -.
DR OMA; TCKERPL; -.
DR OrthoDB; 225688at2759; -.
DR PhylomeDB; O54824; -.
DR TreeFam; TF326303; -.
DR Reactome; R-MMU-449836; Other interleukin signaling.
DR BioGRID-ORCS; 16170; 1 hit in 75 CRISPR screens.
DR ChiTaRS; Il16; mouse.
DR PRO; PR:O54824; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; O54824; protein.
DR Bgee; ENSMUSG00000001741; Expressed in chordate pharynx and 146 other tissues.
DR ExpressionAtlas; O54824; baseline and differential.
DR Genevisible; O54824; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0090543; C:Flemming body; ISO:MGI.
DR GO; GO:0005925; C:focal adhesion; ISO:MGI.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0042609; F:CD4 receptor binding; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:ARUK-UCL.
DR GO; GO:0050930; P:induction of positive chemotaxis; IDA:MGI.
DR GO; GO:0030595; P:leukocyte chemotaxis; IDA:MGI.
DR GO; GO:0032722; P:positive regulation of chemokine production; IDA:ARUK-UCL.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:ARUK-UCL.
DR GO; GO:0050729; P:positive regulation of inflammatory response; ISO:MGI.
DR GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; ISO:MGI.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:MGI.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:MGI.
DR GO; GO:1902565; P:positive regulation of neutrophil activation; IDA:ARUK-UCL.
DR GO; GO:0051924; P:regulation of calcium ion transport; ISO:MGI.
DR Gene3D; 2.30.42.10; -; 4.
DR InterPro; IPR020450; IL-16.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00595; PDZ; 4.
DR PRINTS; PR01931; INTRLEUKIN16.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF50156; SSF50156; 4.
DR PROSITE; PS50106; PDZ; 4.
PE 1: Evidence at protein level;
KW Alternative promoter usage; Chemotaxis; Cytokine; Cytoplasm; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Secreted; Transcription;
KW Transcription regulation.
FT CHAIN 1..1322
FT /note="Pro-interleukin-16"
FT /id="PRO_0000377546"
FT CHAIN 1205..1322
FT /note="Interleukin-16"
FT /evidence="ECO:0000250"
FT /id="PRO_0000015418"
FT DOMAIN 213..299
FT /note="PDZ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 352..437
FT /note="PDZ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 1105..1190
FT /note="PDZ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 1226..1309
FT /note="PDZ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 104..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..449
FT /note="Interaction with GRIN2A"
FT /evidence="ECO:0000250"
FT REGION 480..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1195
FT /note="Interaction with PPP1R12A, PPP1R12B and PPP1R12C"
FT /evidence="ECO:0000250"
FT COMPBIAS 104..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..588
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..682
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 917
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q14005"
FT VAR_SEQ 1..698
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|PubMed:9510557,
FT ECO:0000303|PubMed:9637508"
FT /id="VSP_037460"
FT CONFLICT 264
FT /note="I -> S (in Ref. 5; BAD90484)"
FT /evidence="ECO:0000305"
FT CONFLICT 733
FT /note="T -> R (in Ref. 1; AAC04383)"
FT /evidence="ECO:0000305"
FT CONFLICT 921
FT /note="G -> S (in Ref. 2; AAC16039)"
FT /evidence="ECO:0000305"
FT CONFLICT 1067
FT /note="S -> P (in Ref. 2; AAC16039)"
FT /evidence="ECO:0000305"
FT CONFLICT 1224
FT /note="V -> A (in Ref. 2; AAC16039)"
FT /evidence="ECO:0000305"
FT CONFLICT 1262..1264
FT /note="TEQ -> DRT (in Ref. 1; AAC04383)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1322 AA; 141435 MW; DDB94003A5DCB738 CRC64;
MEPHGHSGKS RKSTKFRSIS RSLILCNAKT SDDGSSPDEK YPDPFETSLC QGKEGFFHSS
MQLADTFEAG LSNIPDLALA SDSAQLAAAG SDRGKHCRKM FFMKESSSTS SKEKSGKPEA
QSSSFLFPKA CHQRTRSNST SVNPYSAGEI DFPMTKKSAA PTDRQPYSLC SNRKSLSQQL
DYPILGTARP TRSLSTAQLG QLSGGLQASV ISNIVLMKGQ AKGLGFSIVG GKDSIYGPIG
IYVKSIFAGG AAAADGRLQE GDEILELNGE SMAGLTHQDA LQKFKQAKKG LLTLTVRTRL
TTPPSLCSHL SPPLCRSLSS STCGAQDSSP FSLESPASPA STAKPNYRIM VEVSLKKEAG
VGLGIGLCSI PYFQCISGIF VHTLSPGSVA HLDGRLRCGD EIVEINDSPV HCLTLNEVYT
ILSHCDPGPV PIIVSRHPDP QVSEQQLKEA VAQAVEGVKF GKDRHQWSLE GVKRLESSWH
GRPTLEKERE KHSAPPHRRA QKIMVRSSSD SSYMSGSPGG SPCSAGAEPQ PSEREGSTHS
PSLSPGEEQE PCPGVPSRPQ QESPPLPESL ERESHPPLRL KKSFEILVRK PTSSKPKPPP
RKYFKNDSEP QKKLEEKEKV TDPSGHTLPT CSQETRELLP LLLQEDTAGR APCTAACCPG
PAASTQTSSS TEGESRRSAS PETPASPGKH PLLKRQARMD YSFDITAEDP WVRISDCIKN
LFSPIMSENH SHTPLQPNTS LGEEDGTQGC PEGGLSKMDA ANGAPRVYKS ADGSTVKKGP
PVAPKPAWFR QSLKGLRNRA PDPRRPPEVA SAIQPTPVSR DPPGPQPQAS SSIRQRISSF
ENFGSSQLPD RGVQRLSLQP SSGETTKFPG KQDGGRFSGL LGQGATVTAK HRQTEVESMS
TTFPNSSEVR DPGLPESPPP GQRPSTKALS PDPLLRLLTT QSEDTQGPGL KMPSQRARSF
PLTRTQSCET KLLDEKASKL YSISSQLSSA VMKSLLCLPS SVSCGQITCI PKERVSPKSP
CNNSSAAEGF GEAMASDTGF SLNLSELREY SEGLTEPGET EDRNHCSSQA GQSVISLLSA
EELEKLIEEV RVLDEATLKQ LDSIHVTILH KEEGAGLGFS LAGGADLENK VITVHRVFPN
GLASQEGTIQ KGNEVLSING KSLKGATHND ALAILRQARD PRQAVIVTRR TTVEATHDLN
SSTDSAASAS AASDISVESK EATVCTVTLE KTSAGLGFSL EGGKGSLHGD KPLTINRIFK
GTEQGEMVQP GDEILQLAGT AVQGLTRFEA WNVIKALPDG PVTIVIRRTS LQCKQTTASA
DS
