ID   IL171_CAEEL             Reviewed;         221 AA.
AC   Q22687;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Interleukin cytokine-related protein 17.1 {ECO:0000312|WormBase:T22H6.1};
DE   AltName: Full=Interleukin 17 cytokine-related protein 1 {ECO:0000305|PubMed:28099418};
DE   Flags: Precursor;
GN   Name=ilc-17.1 {ECO:0000303|PubMed:28099418, ECO:0000312|WormBase:T22H6.1};
GN   ORFNames=T22H6.1 {ECO:0000312|WormBase:T22H6.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MUTAGENESIS OF ALA-194 AND GLY-207.
RX   PubMed=28099418; DOI=10.1038/nature20818;
RA   Chen C., Itakura E., Nelson G.M., Sheng M., Laurent P., Fenk L.A.,
RA   Butcher R.A., Hegde R.S., de Bono M.;
RT   "IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses.";
RL   Nature 542:43-48(2017).
CC   -!- FUNCTION: Ligand for the receptor complex composed of ilcr-1 and ilcr-
CC       2. Binding to the ilcr-1/2 receptor complex triggers a signaling
CC       cascade, activating the downsteam signaling components actl-1, pik-1
CC       and nfki-1, and results in increased neuronal activity in RMG
CC       interneurons in response to input from oxygen-sensing neurons. This
CC       leads to increased animal movement and promotes aggregation behavior.
CC       Plays a role in the responsiveness of RMG interneurons to ascaroside
CC       pheromones. {ECO:0000269|PubMed:28099418}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with the receptor
CC       complex composed of ilcr-1 and ilcr-2 with the interaction being
CC       mediated by ilcr-2. {ECO:0000269|PubMed:28099418}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28099418}.
CC   -!- TISSUE SPECIFICITY: Expressed in RMG and AUA interneurons and ASE
CC       sensory neurons. {ECO:0000269|PubMed:28099418}.
CC   -!- SIMILARITY: Belongs to the IL-17 family. {ECO:0000305}.
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DR   EMBL; BX284606; CAA90671.2; -; Genomic_DNA.
DR   RefSeq; NP_510131.2; NM_077730.2.
DR   AlphaFoldDB; Q22687; -.
DR   STRING; 6239.T22H6.1; -.
DR   PaxDb; Q22687; -.
DR   EnsemblMetazoa; T22H6.1.1; T22H6.1.1; WBGene00011937.
DR   GeneID; 188767; -.
DR   KEGG; cel:CELE_T22H6.1; -.
DR   UCSC; T22H6.1; c. elegans.
DR   CTD; 188767; -.
DR   WormBase; T22H6.1; CE42221; WBGene00011937; ilc-17.1.
DR   eggNOG; ENOG502TGAX; Eukaryota.
DR   HOGENOM; CLU_1251661_0_0_1; -.
DR   InParanoid; Q22687; -.
DR   OMA; SHYSPIA; -.
DR   OrthoDB; 1205675at2759; -.
DR   PRO; PR:Q22687; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00011937; Expressed in larva.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0040017; P:positive regulation of locomotion; IMP:UniProtKB.
DR   GO; GO:0070482; P:response to oxygen levels; IMP:UniProtKB.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR010345; IL-17_fam.
DR   Pfam; PF06083; IL17; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..221
FT                   /note="Interleukin cytokine-related protein 17.1"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000445232"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   DISULFID        148..195
FT                   /evidence="ECO:0000250|UniProtKB:Q16552"
FT   MUTAGEN         194
FT                   /note="A->V: In db1039; defective aggregation behavior."
FT                   /evidence="ECO:0000269|PubMed:28099418"
FT   MUTAGEN         207
FT                   /note="G->R: Defective aggregation behavior."
FT                   /evidence="ECO:0000269|PubMed:28099418"
SQ   SEQUENCE   221 AA;  25579 MW;  AF35CFBB09AB6B95 CRC64;
     MPKSPHRTNL QSFYPIMIIL THLALDSNCW RIRREVDGEE EDIMPSEECY HKYNEENHFK
     VFSNYLNRKN SSHYSPIAPS YQQALLRLQV KGLKHGEQIT KSSGKCNSKK LDTISAETPL
     RDRALCKFEY VLNYNPKRLP AALTEVKCSC PRPNSKLVGK RIFECEHLRY QVRVLMWDDS
     CNTFREHVET IALACIPVIQ ANANADGDDD FIYTIKAEIP I