IL17B_HUMAN
ID IL17B_HUMAN Reviewed; 180 AA.
AC Q9UHF5; Q14CE5;
DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Interleukin-17B;
DE Short=IL-17B;
DE AltName: Full=Cytokine Zcyto7;
DE AltName: Full=Interleukin-20;
DE Short=IL-20;
DE AltName: Full=Neuronal interleukin-17-related factor;
DE Flags: Precursor;
GN Name=IL17B; Synonyms=IL20, NIRF, ZCYTO7; ORFNames=UNQ516/PRO1031;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Presnell S., Gilbert T., Whitmore T., Foster D., Hart C., Lehner J.,
RA Martinez T., Hoffman R., O'Hara P.;
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10749887; DOI=10.1074/jbc.m910228199;
RA Shi Y., Ullrich S.J., Zhang J., Connolly K., Grzegorzewski K.J.,
RA Barber M.C., Wang W., Wathen K., Hodge V., Fisher C.L., Olsen H.,
RA Ruben S.M., Knyazev I., Cho Y.H., Kao V., Wilkinson K.A., Carrell J.A.,
RA Ebner R.;
RT "A novel cytokine receptor-ligand pair. Identification, molecular
RT characterization, and in vivo immunomodulatory activity.";
RL J. Biol. Chem. 275:19167-19176(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10639155; DOI=10.1073/pnas.97.2.773;
RA Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P.,
RA Gurney A.L., Wood W.I.;
RT "Cloning and characterization of IL-17B and IL-17C, two new members of the
RT IL-17 cytokine family.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Moore E.E., Presnell S., Garrigues U., Guilbot A., LeGuern E., Smith D.,
RA Yao L., Whitmore T.E., Gilbert T., Kuestner R.E.;
RT "Identification of a novel IL-17 related factor: demonstration of neuronal
RT expression and evaluation as a candidate for the chromosome 5q-linked form
RT of Charcot-Marie-Tooth disease.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhang W., Wang J., Cao X.;
RT "Novel cytokine homology with interleukin-17.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG SeattleSNPs variation discovery resource;
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-
CC 1-beta from the monocytic cell line THP-1.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in adult pancreas, small intestine,
CC stomach, spinal cord and testis. Less pronounced expression in
CC prostate, colon mucosal lining, and ovary.
CC -!- SIMILARITY: Belongs to the IL-17 family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry;
CC URL="https://en.wikipedia.org/wiki/Interleukin_17";
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/il17b/";
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DR EMBL; AF184969; AAF01318.1; -; mRNA.
DR EMBL; AF212311; AAF78775.1; -; mRNA.
DR EMBL; AF152098; AAF28104.1; -; mRNA.
DR EMBL; AF218727; AAG44136.1; -; mRNA.
DR EMBL; AF110385; AAG39637.1; -; mRNA.
DR EMBL; AY358931; AAQ89290.1; -; mRNA.
DR EMBL; AF386077; AAK60336.1; -; Genomic_DNA.
DR EMBL; BC113925; AAI13926.1; -; mRNA.
DR EMBL; BC113946; AAI13947.1; -; mRNA.
DR CCDS; CCDS4297.1; -.
DR RefSeq; NP_001304916.1; NM_001317987.1.
DR RefSeq; NP_055258.1; NM_014443.2.
DR AlphaFoldDB; Q9UHF5; -.
DR SMR; Q9UHF5; -.
DR BioGRID; 118065; 87.
DR IntAct; Q9UHF5; 2.
DR STRING; 9606.ENSP00000261796; -.
DR GlyGen; Q9UHF5; 1 site.
DR BioMuta; IL17B; -.
DR DMDM; 20143877; -.
DR MassIVE; Q9UHF5; -.
DR PaxDb; Q9UHF5; -.
DR PeptideAtlas; Q9UHF5; -.
DR PRIDE; Q9UHF5; -.
DR ProteomicsDB; 84343; -.
DR Antibodypedia; 27818; 453 antibodies from 33 providers.
DR DNASU; 27190; -.
DR Ensembl; ENST00000261796.4; ENSP00000261796.3; ENSG00000127743.6.
DR GeneID; 27190; -.
DR KEGG; hsa:27190; -.
DR MANE-Select; ENST00000261796.4; ENSP00000261796.3; NM_014443.3; NP_055258.1.
DR UCSC; uc003lqo.4; human.
DR CTD; 27190; -.
DR DisGeNET; 27190; -.
DR GeneCards; IL17B; -.
DR HGNC; HGNC:5982; IL17B.
DR HPA; ENSG00000127743; Low tissue specificity.
DR MIM; 604627; gene.
DR neXtProt; NX_Q9UHF5; -.
DR OpenTargets; ENSG00000127743; -.
DR PharmGKB; PA29795; -.
DR VEuPathDB; HostDB:ENSG00000127743; -.
DR eggNOG; ENOG502S074; Eukaryota.
DR GeneTree; ENSGT00940000160854; -.
DR HOGENOM; CLU_100619_1_0_1; -.
DR InParanoid; Q9UHF5; -.
DR OMA; WPHNLLL; -.
DR OrthoDB; 1298853at2759; -.
DR PhylomeDB; Q9UHF5; -.
DR TreeFam; TF314701; -.
DR PathwayCommons; Q9UHF5; -.
DR SignaLink; Q9UHF5; -.
DR SIGNOR; Q9UHF5; -.
DR BioGRID-ORCS; 27190; 11 hits in 1066 CRISPR screens.
DR GenomeRNAi; 27190; -.
DR Pharos; Q9UHF5; Tbio.
DR PRO; PR:Q9UHF5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9UHF5; protein.
DR Bgee; ENSG00000127743; Expressed in tibia and 107 other tissues.
DR Genevisible; Q9UHF5; HS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; TAS:ProtInc.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0006955; P:immune response; TAS:ProtInc.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020440; IL-17_chr.
DR InterPro; IPR010345; IL-17_fam.
DR Pfam; PF06083; IL17; 1.
DR PRINTS; PR01932; INTRLEUKIN17.
DR SUPFAM; SSF57501; SSF57501; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..180
FT /note="Interleukin-17B"
FT /id="PRO_0000015426"
FT REGION 22..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 121..176
FT /evidence="ECO:0000250"
FT DISULFID 126..178
FT /evidence="ECO:0000250"
SQ SEQUENCE 180 AA; 20437 MW; F1B0BC1446D0B14A CRC64;
MDWPHNLLFL LTISIFLGLG QPRSPKSKRK GQGRPGPLAP GPHQVPLDLV SRMKPYARME
EYERNIEEMV AQLRNSSELA QRKCEVNLQL WMSNKRSLSP WGYSINHDPS RIPVDLPEAR
CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR RRLCPPPPRT GPCRQRAVME TIAVGCTCIF
