ID   IL17B_MESAU             Reviewed;         178 AA.
AC   Q9EQI6;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Interleukin-17B;
DE            Short=IL-17B;
DE   AltName: Full=Neuronal interleukin-17-related factor;
DE   Flags: Precursor; Fragment;
GN   Name=IL17B; Synonyms=NIRF;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11738356; DOI=10.1016/s0960-8966(01)00250-4;
RA   Moore E.E., Presnell S., Garrigues U., Guilbot A., LeGuern E., Smith D.,
RA   Yao L., Whitmore T.E., Gilbert T., Palmer T.D., Horner P.J., Kuestner R.E.;
RT   "Expression of IL-17B in neurons and evaluation of its possible role in the
RT   chromosome 5q-linked form of Charcot-Marie-Tooth disease.";
RL   Neuromuscul. Disord. 12:141-150(2002).
CC   -!- FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-
CC       1-beta from the monocytic cell line THP-1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-17 family. {ECO:0000305}.
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DR   EMBL; AF218725; AAG44134.1; -; mRNA.
DR   AlphaFoldDB; Q9EQI6; -.
DR   SMR; Q9EQI6; -.
DR   STRING; 10036.XP_005074783.1; -.
DR   PRIDE; Q9EQI6; -.
DR   eggNOG; ENOG502S074; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020440; IL-17_chr.
DR   InterPro; IPR010345; IL-17_fam.
DR   Pfam; PF06083; IL17; 1.
DR   PRINTS; PR01932; INTRLEUKIN17.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..>178
FT                   /note="Interleukin-17B"
FT                   /id="PRO_0000015427"
FT   REGION          21..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        121..176
FT                   /evidence="ECO:0000250"
FT   DISULFID        126..178
FT                   /evidence="ECO:0000250"
FT   NON_TER         178
SQ   SEQUENCE   178 AA;  20071 MW;  03D02D60BEC89A51 CRC64;
     MDWPHSLLFL LAISIFLGPS QPRNTKGKRK GQVRPGPLAP GPHQVPLDLV SRVKPYARME
     EYERNLGEMV AQLRNSSEPA KRRCEVNLQL WLSNKRSLSP WGYSINHDPS RIPADLPEAR
     CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR RRLCPPPPRP GPCRHRVVME TIAVGCTC