IL17B_MOUSE
ID IL17B_MOUSE Reviewed; 180 AA.
AC Q9QXT6; Q99MY3; Q9CTI4;
DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Interleukin-17B;
DE Short=IL-17B;
DE AltName: Full=Cytokine CX1;
DE AltName: Full=Cytokine-like protein ZCYTO7;
DE AltName: Full=Neuronal interleukin-17-related factor;
DE Flags: Precursor;
GN Name=Il17b; Synonyms=Nirf, Zcyto7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Presnell S., Gilbert T., Whitmore T., Foster D., Hart C., Lehner J.,
RA Martinez T., Hoffman R., O'Hara P.;
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Moore E.E., Presnell S., Garrigues U., Guilbot A., LeGuern E., Smith D.,
RA Yao L., Whitmore T.E., Gilbert T., Kuestner R.E.;
RT "Identification of a novel IL-17 related factor: demonstration of neuronal
RT expression and evaluation as a candidate for the chromosome 5q-linked form
RT of Charcot-Marie-Tooth disease.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Zhang W., Cao X.;
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Stimulates the release of tumor necrosis factor alpha and IL-
CC 1-beta from the monocytic cell line THP-1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-17 family. {ECO:0000305}.
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DR EMBL; AF184970; AAF01319.1; -; mRNA.
DR EMBL; AF218726; AAG44135.1; -; mRNA.
DR EMBL; AF250308; AAK37427.1; -; mRNA.
DR EMBL; AK003506; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC002271; AAH02271.1; -; mRNA.
DR CCDS; CCDS29286.1; -.
DR RefSeq; NP_062381.1; NM_019508.1.
DR AlphaFoldDB; Q9QXT6; -.
DR SMR; Q9QXT6; -.
DR STRING; 10090.ENSMUSP00000025471; -.
DR GlyGen; Q9QXT6; 1 site.
DR PaxDb; Q9QXT6; -.
DR PRIDE; Q9QXT6; -.
DR ProteomicsDB; 269388; -.
DR Antibodypedia; 27818; 453 antibodies from 33 providers.
DR DNASU; 56069; -.
DR Ensembl; ENSMUST00000025471; ENSMUSP00000025471; ENSMUSG00000024578.
DR GeneID; 56069; -.
DR KEGG; mmu:56069; -.
DR UCSC; uc008fck.1; mouse.
DR CTD; 27190; -.
DR MGI; MGI:1928397; Il17b.
DR VEuPathDB; HostDB:ENSMUSG00000024578; -.
DR eggNOG; ENOG502S074; Eukaryota.
DR GeneTree; ENSGT00940000160854; -.
DR HOGENOM; CLU_100619_1_0_1; -.
DR InParanoid; Q9QXT6; -.
DR OMA; WPHNLLL; -.
DR OrthoDB; 1298853at2759; -.
DR PhylomeDB; Q9QXT6; -.
DR TreeFam; TF314701; -.
DR BioGRID-ORCS; 56069; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Il17b; mouse.
DR PRO; PR:Q9QXT6; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q9QXT6; protein.
DR Bgee; ENSMUSG00000024578; Expressed in mammary bud and 50 other tissues.
DR ExpressionAtlas; Q9QXT6; baseline and differential.
DR Genevisible; Q9QXT6; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0030593; P:neutrophil chemotaxis; ISO:MGI.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IDA:MGI.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020440; IL-17_chr.
DR InterPro; IPR010345; IL-17_fam.
DR Pfam; PF06083; IL17; 1.
DR PRINTS; PR01932; INTRLEUKIN17.
DR SUPFAM; SSF57501; SSF57501; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..180
FT /note="Interleukin-17B"
FT /id="PRO_0000015428"
FT REGION 22..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 121..176
FT /evidence="ECO:0000250"
FT DISULFID 126..178
FT /evidence="ECO:0000250"
FT CONFLICT 1..7
FT /note="MDWPHSL -> YPTSTFS (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="G -> R (in Ref. 4)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="R -> K (in Ref. 3; AAK37427)"
FT /evidence="ECO:0000305"
FT CONFLICT 65
FT /note="N -> T (in Ref. 3; AAK37427)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="S -> I (in Ref. 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 180 AA; 20309 MW; E26F4C72001997C5 CRC64;
MDWPHSLLFL LAISIFLAPS HPRNTKGKRK GQGRPSPLAP GPHQVPLDLV SRVKPYARME
EYERNLGEMV AQLRNSSEPA KKKCEVNLQL WLSNKRSLSP WGYSINHDPS RIPADLPEAR
CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR RRLCPQPPRP GPCRQRVVME TIAVGCTCIF
