IL17D_HUMAN
ID IL17D_HUMAN Reviewed; 202 AA.
AC Q8TAD2; B1AM69;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Interleukin-17D;
DE Short=IL-17D;
DE AltName: Full=Interleukin-27 {ECO:0000303|Ref.2};
DE Short=IL-27 {ECO:0000303|Ref.2};
DE Flags: Precursor;
GN Name=IL17D; ORFNames=UNQ3096/PRO21175;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12097364; DOI=10.4049/jimmunol.169.2.642;
RA Starnes T., Broxmeyer H.E., Robertson M.J., Hromas R.;
RT "Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates
RT cytokine production and inhibits hemopoiesis.";
RL J. Immunol. 169:642-646(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RA Hadj-Slimane R., Bobe P.;
RT "Interleukin 27 (IL27): a newly identified cytokine.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gilbert J.M., Gorman D.M.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from
CC endothelial cells. {ECO:0000269|PubMed:12097364}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed preferentially in adipose, skeletal
CC muscle and CNS. {ECO:0000269|PubMed:12097364}.
CC -!- SIMILARITY: Belongs to the IL-17 family. {ECO:0000305}.
CC -!- CAUTION: IL17D nucleotide sequence has been submitted under the name
CC IL27 in INSDC AY078238 (Ref.2). However, the protein shown in this
CC entry should not be confused with the actual IL27 protein, which forms
CC a heterodimeric cytokine by interaction with EBI3. In order to avoid
CC any ambiguity, we strongly recommend using the official HGNC
CC nomenclature. {ECO:0000305|Ref.2}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry;
CC URL="https://en.wikipedia.org/wiki/Interleukin_17";
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DR EMBL; AY078238; AAL86911.1; -; mRNA.
DR EMBL; AF479775; AAM12734.1; -; mRNA.
DR EMBL; AF458062; AAM77566.1; -; mRNA.
DR EMBL; AY359113; AAQ89471.1; -; mRNA.
DR EMBL; AL161772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL512652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08276.1; -; Genomic_DNA.
DR EMBL; BC036243; AAH36243.1; -; mRNA.
DR CCDS; CCDS9292.1; -.
DR RefSeq; NP_612141.1; NM_138284.1.
DR AlphaFoldDB; Q8TAD2; -.
DR SMR; Q8TAD2; -.
DR BioGRID; 119743; 107.
DR IntAct; Q8TAD2; 1.
DR MINT; Q8TAD2; -.
DR STRING; 9606.ENSP00000302924; -.
DR GlyGen; Q8TAD2; 2 sites.
DR iPTMnet; Q8TAD2; -.
DR PhosphoSitePlus; Q8TAD2; -.
DR BioMuta; IL17D; -.
DR DMDM; 46576614; -.
DR MassIVE; Q8TAD2; -.
DR PaxDb; Q8TAD2; -.
DR PeptideAtlas; Q8TAD2; -.
DR PRIDE; Q8TAD2; -.
DR ProteomicsDB; 73860; -.
DR Antibodypedia; 22328; 445 antibodies from 31 providers.
DR DNASU; 53342; -.
DR Ensembl; ENST00000304920.3; ENSP00000302924.3; ENSG00000172458.5.
DR Ensembl; ENST00000682841.1; ENSP00000508385.1; ENSG00000172458.5.
DR GeneID; 53342; -.
DR KEGG; hsa:53342; -.
DR MANE-Select; ENST00000682841.1; ENSP00000508385.1; NM_001385224.1; NP_001372153.1.
DR UCSC; uc001unm.3; human.
DR CTD; 53342; -.
DR DisGeNET; 53342; -.
DR GeneCards; IL17D; -.
DR HGNC; HGNC:5984; IL17D.
DR HPA; ENSG00000172458; Group enriched (brain, skeletal muscle).
DR MIM; 607587; gene.
DR neXtProt; NX_Q8TAD2; -.
DR OpenTargets; ENSG00000172458; -.
DR PharmGKB; PA29798; -.
DR VEuPathDB; HostDB:ENSG00000172458; -.
DR eggNOG; ENOG502RXIG; Eukaryota.
DR GeneTree; ENSGT00940000161739; -.
DR HOGENOM; CLU_100619_0_0_1; -.
DR InParanoid; Q8TAD2; -.
DR OMA; SYDPKRY; -.
DR OrthoDB; 1298853at2759; -.
DR PhylomeDB; Q8TAD2; -.
DR TreeFam; TF314701; -.
DR PathwayCommons; Q8TAD2; -.
DR SignaLink; Q8TAD2; -.
DR BioGRID-ORCS; 53342; 17 hits in 1066 CRISPR screens.
DR ChiTaRS; IL17D; human.
DR GenomeRNAi; 53342; -.
DR Pharos; Q8TAD2; Tbio.
DR PRO; PR:Q8TAD2; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q8TAD2; protein.
DR Bgee; ENSG00000172458; Expressed in vastus lateralis and 143 other tissues.
DR ExpressionAtlas; Q8TAD2; baseline and differential.
DR Genevisible; Q8TAD2; HS.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005125; F:cytokine activity; IDA:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0048018; F:receptor ligand activity; IDA:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IDA:UniProtKB.
DR GO; GO:1903707; P:negative regulation of hemopoiesis; IDA:UniProtKB.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IDA:UniProtKB.
DR GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IDA:UniProtKB.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IDA:UniProtKB.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IDA:UniProtKB.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020440; IL-17_chr.
DR InterPro; IPR010345; IL-17_fam.
DR Pfam; PF06083; IL17; 1.
DR PRINTS; PR01932; INTRLEUKIN17.
DR SUPFAM; SSF57501; SSF57501; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..202
FT /note="Interleukin-17D"
FT /id="PRO_0000015430"
FT REGION 65..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 78
FT /note="A -> G (in Ref. 4; AAQ89471)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 202 AA; 21893 MW; D171C5FB2DD039C3 CRC64;
MLVAGFLLAL PPSWAAGAPR AGRRPARPRG CADRPEELLE QLYGRLAAGV LSAFHHTLQL
GPREQARNAS CPAGGRPADR RFRPPTNLRS VSPWAYRISY DPARYPRYLP EAYCLCRGCL
TGLFGEEDVR FRSAPVYMPT VVLRRTPACA GGRSVYTEAY VTIPVGCTCV PEPEKDADSI
NSSIDKQGAK LLLGPNDAPA GP
