IL17F_RAT
ID IL17F_RAT Reviewed; 161 AA.
AC Q5BJ95;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Interleukin-17F;
DE Short=IL-17F;
DE Flags: Precursor;
GN Name=Il17f;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Effector cytokine of innate and adaptive immune system
CC involved in antimicrobial host defense and maintenance of tissue
CC integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor
CC complex, triggering homotypic interaction of IL17RA and IL17RC chains
CC with TRAF3IP2 adapter through SEFIR domains. This leads to downstream
CC TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways
CC ultimately resulting in transcriptional activation of cytokines,
CC chemokines, antimicrobial peptides and matrix metalloproteinases, with
CC potential strong immune inflammation. IL17A-IL17F is primarily involved
CC in host defense against extracellular bacteria and fungi by inducing
CC neutrophilic inflammation. As signature effector cytokine of T-helper
CC 17 cells (Th17), primarily induces neutrophil activation and
CC recruitment at infection and inflammatory sites. Stimulates the
CC production of antimicrobial beta-defensins DEFB1, DEFB103A, and
CC DEFB104A by mucosal epithelial cells, limiting the entry of microbes
CC through the epithelial barriers. IL17F homodimer can signal via IL17RC
CC homodimeric receptor complex, triggering downstream activation of TRAF6
CC and NF-kappa-B signaling pathway. Via IL17RC induces transcriptional
CC activation of IL33, a potent cytokine that stimulates group 2 innate
CC lymphoid cells and adaptive T-helper 2 cells involved in pulmonary
CC allergic response to fungi. Likely via IL17RC, promotes sympathetic
CC innervation of peripheral organs by coordinating the communication
CC between gamma-delta T cells and parenchymal cells. Stimulates
CC sympathetic innervation of thermogenic adipose tissue by driving TGFB1
CC expression. Regulates the composition of intestinal microbiota and
CC immune tolerance by inducing antimicrobial proteins that specifically
CC control the growth of commensal Firmicutes and Bacteroidetes.
CC {ECO:0000250|UniProtKB:Q7TNI7, ECO:0000250|UniProtKB:Q96PD4}.
CC -!- SUBUNIT: Homodimer; disulfide-linked (By similarity). Heterodimer with
CC IL17A (IL17A-IL17F) (By similarity). Forms complexes with IL17RA and
CC IL17RC receptors with 2:1 binding stoichiometry: two receptor chains
CC for one interleukin molecule. IL17F homodimer forms predominantly
CC complexes with IL17RC homodimer, whereas IL17A-IL17F favors complexes
CC with IL17RA-IL17RC. IL17RA and IL17RC chains cannot distinguish between
CC IL17A and IL17F molecules, potentially enabling the formation of
CC topologically distinct complexes (By similarity).
CC {ECO:0000250|UniProtKB:Q7TNI7, ECO:0000250|UniProtKB:Q96PD4}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q7TNI7}.
CC -!- SIMILARITY: Belongs to the IL-17 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH91568.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC091568; AAH91568.1; ALT_INIT; mRNA.
DR RefSeq; NP_001015011.2; NM_001015011.2.
DR AlphaFoldDB; Q5BJ95; -.
DR SMR; Q5BJ95; -.
DR STRING; 10116.ENSRNOP00000016717; -.
DR GlyGen; Q5BJ95; 1 site.
DR iPTMnet; Q5BJ95; -.
DR PhosphoSitePlus; Q5BJ95; -.
DR PaxDb; Q5BJ95; -.
DR Ensembl; ENSRNOT00000016717; ENSRNOP00000016717; ENSRNOG00000012509.
DR GeneID; 301291; -.
DR KEGG; rno:301291; -.
DR UCSC; RGD:1311398; rat.
DR CTD; 112744; -.
DR RGD; 1311398; Il17f.
DR eggNOG; ENOG502S5A0; Eukaryota.
DR GeneTree; ENSGT00940000156618; -.
DR HOGENOM; CLU_118641_0_0_1; -.
DR InParanoid; Q5BJ95; -.
DR OrthoDB; 1469254at2759; -.
DR PhylomeDB; Q5BJ95; -.
DR TreeFam; TF314701; -.
DR PRO; PR:Q5BJ95; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Genevisible; Q5BJ95; RN.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0005125; F:cytokine activity; ISO:RGD.
DR GO; GO:0019955; F:cytokine binding; ISO:RGD.
DR GO; GO:0005126; F:cytokine receptor binding; ISO:RGD.
DR GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
DR GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; ISO:RGD.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:RGD.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0097400; P:interleukin-17-mediated signaling pathway; ISO:RGD.
DR GO; GO:0016525; P:negative regulation of angiogenesis; ISO:RGD.
DR GO; GO:0002225; P:positive regulation of antimicrobial peptide production; ISO:RGD.
DR GO; GO:2000340; P:positive regulation of chemokine (C-X-C motif) ligand 1 production; ISO:RGD.
DR GO; GO:0001819; P:positive regulation of cytokine production; ISO:RGD.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; ISO:RGD.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:RGD.
DR GO; GO:0032761; P:positive regulation of lymphotoxin A production; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0032645; P:regulation of granulocyte macrophage colony-stimulating factor production; ISO:RGD.
DR GO; GO:0032663; P:regulation of interleukin-2 production; ISO:RGD.
DR GO; GO:0032675; P:regulation of interleukin-6 production; ISO:RGD.
DR GO; GO:0032677; P:regulation of interleukin-8 production; ISO:RGD.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020440; IL-17_chr.
DR InterPro; IPR010345; IL-17_fam.
DR Pfam; PF06083; IL17; 1.
DR PRINTS; PR01932; INTRLEUKIN17.
DR SUPFAM; SSF57501; SSF57501; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Cytokine; Disulfide bond; Glycoprotein; Immunity;
KW Inflammatory response; Innate immunity; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..161
FT /note="Interleukin-17F"
FT /evidence="ECO:0000255"
FT /id="PRO_0000378105"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT DISULFID 45
FT /note="Interchain (with C-135)"
FT /evidence="ECO:0000250|UniProtKB:Q96PD4"
FT DISULFID 100..150
FT /evidence="ECO:0000250|UniProtKB:Q96PD4"
FT DISULFID 105..152
FT /evidence="ECO:0000250|UniProtKB:Q96PD4"
FT DISULFID 135
FT /note="Interchain (with C-45)"
FT /evidence="ECO:0000250|UniProtKB:Q96PD4"
SQ SEQUENCE 161 AA; 17712 MW; 8F1ACDD70FA84860 CRC64;
MKGSCETTMV KSLLLLMLGF AIISSGAARR NPKVGLSALQ KAGNCPPLED NSVRVDIRIF
NQNQGISVPR DFQNRSSSPW DYNITRDPDR FPSEIAEAQC RHSGCINAQG QEDGSMNSVP
IQQEILVLRR EPQGCSNSFR LEKMLIKVGC TCVTPIVHHA A
