ID   IL17L_CRAGI             Reviewed;         200 AA.
AC   A9XE49;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Interleukin 17-like protein;
DE            Short=CgIL-17 {ECO:0000303|PubMed:18395796};
DE   Flags: Precursor;
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABO93467.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Hemocyte {ECO:0000269|PubMed:18395796};
RX   PubMed=18395796; DOI=10.1016/j.dci.2008.02.006;
RA   Roberts S., Gueguen Y., de Lorgeril J., Goetz F.;
RT   "Rapid accumulation of an interleukin 17 homolog transcript in Crassostrea
RT   gigas hemocytes following bacterial exposure.";
RL   Dev. Comp. Immunol. 32:1099-1104(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q96PD4}.
CC   -!- TISSUE SPECIFICITY: Expressed in several tissues including hemocytes,
CC       gills, mantle, adductor muscle, labial palps, digestive glands and
CC       heart with highest levels in gills and lowest levels in adductor muscle
CC       and heart. {ECO:0000269|PubMed:18395796}.
CC   -!- INDUCTION: By bacterial injection. Levels increase strongly by 6 hours
CC       and slowly decline through 24 and 48 hours.
CC       {ECO:0000269|PubMed:18395796}.
CC   -!- SIMILARITY: Belongs to the IL-17 family. {ECO:0000255}.
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DR   EMBL; EF190193; ABO93467.1; -; mRNA.
DR   RefSeq; NP_001295781.1; NM_001308852.1.
DR   AlphaFoldDB; A9XE49; -.
DR   EnsemblMetazoa; EKC34394; EKC34394; CGI_10025754.
DR   GeneID; 105322542; -.
DR   KEGG; crg:105322542; -.
DR   HOGENOM; CLU_1367425_0_0_1; -.
DR   OMA; PLEENGH; -.
DR   OrthoDB; 1298853at2759; -.
DR   Proteomes; UP000005408; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR010345; IL-17_fam.
DR   Pfam; PF06083; IL17; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..200
FT                   /note="Interleukin 17-like protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000389424"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        192
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        122..175
FT                   /evidence="ECO:0000250|UniProtKB:Q96PD4"
FT   DISULFID        127..177
FT                   /evidence="ECO:0000250|UniProtKB:Q96PD4"
SQ   SEQUENCE   200 AA;  21551 MW;  6CB44BCD15D0A1B1 CRC64;
     MGNFFLFAMT LVVCSVIVLL TGVADSAVIC SEPTNLAEQY SQYMANATVS NMLEYLESST
     AGGVASDEEE QLIYGNRICP SSIKAITTDP KSSVFERTTC PYFLVASHLS TRYPKIITEA
     RCKCSGCVPL EENGHSDLTR CEPVYRPVRV LSRTGNCVNG VYQYAAAVHM KQEGCTCVRK
     TEALSGSGSG SNGSDDPIPM