位置:首页 > 蛋白库 > IL17_MOUSE
IL17_MOUSE
ID   IL17_MOUSE              Reviewed;         158 AA.
AC   Q62386; Q60971;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=Interleukin-17A;
DE            Short=IL-17;
DE            Short=IL-17A;
DE   AltName: Full=Cytotoxic T-lymphocyte-associated antigen 8;
DE            Short=CTLA-8;
DE   Flags: Precursor;
GN   Name=Il17a; Synonyms=Ctla8, Il17;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BALB/cJ; TISSUE=Thymocyte;
RX   PubMed=8877732; DOI=10.1089/jir.1996.16.611;
RA   Kennedy J., Rossi D.L., Zurawski S.M., Vega F. Jr., Kastelein R.A.,
RA   Wagner J.L., Hannum C.H., Zlotnik A.;
RT   "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-
RT   CD8-T cells.";
RL   J. Interferon Cytokine Res. 16:611-617(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-158.
RC   STRAIN=129/Sv; TISSUE=T-cell;
RX   PubMed=8654948; DOI=10.1016/0378-1119(95)00778-4;
RA   Yao Z., Timour M., Painter S., Fanslow W., Spriggs M.K.;
RT   "Complete nucleotide sequence of the mouse CTLA8 gene.";
RL   Gene 168:223-225(1996).
RN   [3]
RP   FUNCTION, AND INDUCTION BY IL23A-IL12B.
RX   PubMed=16200068; DOI=10.1038/ni1261;
RA   Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., Wang Y.,
RA   Hood L., Zhu Z., Tian Q., Dong C.;
RT   "A distinct lineage of CD4 T cells regulates tissue inflammation by
RT   producing interleukin 17.";
RL   Nat. Immunol. 6:1133-1141(2005).
RN   [4]
RP   INDUCTION BY IL6 AND TGFB1, AND TISSUE SPECIFICITY.
RX   PubMed=16990136; DOI=10.1016/j.cell.2006.07.035;
RA   Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A.,
RA   Lafaille J.J., Cua D.J., Littman D.R.;
RT   "The orphan nuclear receptor RORgammat directs the differentiation program
RT   of proinflammatory IL-17+ T helper cells.";
RL   Cell 126:1121-1133(2006).
RN   [5]
RP   FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=17470641; DOI=10.1084/jem.20061551;
RA   Michel M.L., Keller A.C., Paget C., Fujio M., Trottein F., Savage P.B.,
RA   Wong C.H., Schneider E., Dy M., Leite-de-Moraes M.C.;
RT   "Identification of an IL-17-producing NK1.1(neg) iNKT cell population
RT   involved in airway neutrophilia.";
RL   J. Exp. Med. 204:995-1001(2007).
RN   [6]
RP   FUNCTION, INDUCTION BY IL23A-IL12B, AND TISSUE SPECIFICITY.
RX   PubMed=17372004; DOI=10.4049/jimmunol.178.7.4466;
RA   Shibata K., Yamada H., Hara H., Kishihara K., Yoshikai Y.;
RT   "Resident Vdelta1+ gammadelta T cells control early infiltration of
RT   neutrophils after Escherichia coli infection via IL-17 production.";
RL   J. Immunol. 178:4466-4472(2007).
RN   [7]
RP   FUNCTION.
RX   PubMed=17911633; DOI=10.4049/jimmunol.179.8.5462;
RA   Kuestner R.E., Taft D.W., Haran A., Brandt C.S., Brender T., Lum K.,
RA   Harder B., Okada S., Ostrander C.D., Kreindler J.L., Aujla S.J.,
RA   Reardon B., Moore M., Shea P., Schreckhise R., Bukowski T.R., Presnell S.,
RA   Guerra-Lewis P., Parrish-Novak J., Ellsworth J.L., Jaspers S., Lewis K.E.,
RA   Appleby M., Kolls J.K., Rixon M., West J.W., Gao Z., Levin S.D.;
RT   "Identification of the IL-17 receptor related molecule IL-17RC as the
RT   receptor for IL-17F.";
RL   J. Immunol. 179:5462-5473(2007).
RN   [8]
RP   FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBUNIT, AND SUBCELLULAR LOCATION.
RX   PubMed=18025225; DOI=10.4049/jimmunol.179.11.7791;
RA   Liang S.C., Long A.J., Bennett F., Whitters M.J., Karim R., Collins M.,
RA   Goldman S.J., Dunussi-Joannopoulos K., Williams C.M., Wright J.F.,
RA   Fouser L.A.;
RT   "An IL-17F/A heterodimer protein is produced by mouse Th17 cells and
RT   induces airway neutrophil recruitment.";
RL   J. Immunol. 179:7791-7799(2007).
RN   [9]
RP   FUNCTION.
RX   PubMed=18157131; DOI=10.1038/ni1552;
RA   Hsu H.C., Yang P., Wang J., Wu Q., Myers R., Chen J., Yi J., Guentert T.,
RA   Tousson A., Stanus A.L., Le T.V., Lorenz R.G., Xu H., Kolls J.K.,
RA   Carter R.H., Chaplin D.D., Williams R.W., Mountz J.D.;
RT   "Interleukin 17-producing T helper cells and interleukin 17 orchestrate
RT   autoreactive germinal center development in autoimmune BXD2 mice.";
RL   Nat. Immunol. 9:166-175(2008).
RN   [10]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19144317; DOI=10.1016/j.immuni.2008.11.009;
RA   Ishigame H., Kakuta S., Nagai T., Kadoki M., Nambu A., Komiyama Y.,
RA   Fujikado N., Tanahashi Y., Akitsu A., Kotaki H., Sudo K., Nakae S.,
RA   Sasakawa C., Iwakura Y.;
RT   "Differential roles of interleukin-17A and -17F in host defense against
RT   mucoepithelial bacterial infection and allergic responses.";
RL   Immunity 30:108-119(2009).
RN   [11]
RP   FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=20364087; DOI=10.1172/jci40891;
RA   Cho J.S., Pietras E.M., Garcia N.C., Ramos R.I., Farzam D.M., Monroe H.R.,
RA   Magorien J.E., Blauvelt A., Kolls J.K., Cheung A.L., Cheng G., Modlin R.L.,
RA   Miller L.S.;
RT   "IL-17 is essential for host defense against cutaneous Staphylococcus
RT   aureus infection in mice.";
RL   J. Clin. Invest. 120:1762-1773(2010).
RN   [12]
RP   FUNCTION.
RX   PubMed=21946434; DOI=10.1038/cmi.2011.38;
RA   Wang X., Chan C.C., Yang M., Deng J., Poon V.K., Leung V.H., Ko K.H.,
RA   Zhou J., Yuen K.Y., Zheng B.J., Lu L.;
RT   "A critical role of IL-17 in modulating the B-cell response during H5N1
RT   influenza virus infection.";
RL   Cell. Mol. Immunol. 8:462-468(2011).
RN   [13]
RP   FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=23255360; DOI=10.4049/jimmunol.1202924;
RA   Gladiator A., Wangler N., Trautwein-Weidner K., LeibundGut-Landmann S.;
RT   "IL-17-secreting innate lymphoid cells are essential for host defense
RT   against fungal infection.";
RL   J. Immunol. 190:521-525(2013).
RN   [14]
RP   FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=26431948; DOI=10.1016/j.immuni.2015.09.003;
RA   Lee J.S., Tato C.M., Joyce-Shaikh B., Gulen M.F., Gulan F., Cayatte C.,
RA   Chen Y., Blumenschein W.M., Judo M., Ayanoglu G., McClanahan T.K., Li X.,
RA   Cua D.J.;
RT   "Interleukin-23-Independent IL-17 Production Regulates Intestinal
RT   Epithelial Permeability.";
RL   Immunity 43:727-738(2015).
RN   [15]
RP   FUNCTION.
RX   PubMed=27923703; DOI=10.1016/j.chom.2016.10.003;
RA   Chen K., Eddens T., Trevejo-Nunez G., Way E.E., Elsegeiny W., Ricks D.M.,
RA   Garg A.V., Erb C.J., Bo M., Wang T., Chen W., Lee J.S., Gaffen S.L.,
RA   Kolls J.K.;
RT   "IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal
RT   Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.";
RL   Cell Host Microbe 20:596-605(2016).
RN   [16]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=26735852; DOI=10.1371/journal.ppat.1005367;
RA   Wang X., Ma K., Chen M., Ko K.H., Zheng B.J., Lu L.;
RT   "IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of
RT   Blimp-1 Expression during Influenza Virus Infection.";
RL   PLoS Pathog. 12:e1005367-e1005367(2016).
RN   [17]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=27795421; DOI=10.1128/jvi.01529-16;
RA   Acharya D., Wang P., Paul A.M., Dai J., Gate D., Lowery J.E., Stokic D.S.,
RA   Leis A.A., Flavell R.A., Town T., Fikrig E., Bai F.;
RT   "Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile
RT   Virus Clearance.";
RL   J. Virol. 91:0-0(2017).
RN   [18]
RP   FUNCTION, INDUCTION, AND TISSUE SPECIFICITY.
RX   PubMed=28709803; DOI=10.1016/j.immuni.2017.06.014;
RA   St Leger A.J., Desai J.V., Drummond R.A., Kugadas A., Almaghrabi F.,
RA   Silver P., Raychaudhuri K., Gadjeva M., Iwakura Y., Lionakis M.S.,
RA   Caspi R.R.;
RT   "An Ocular Commensal Protects against Corneal Infection by Driving an
RT   Interleukin-17 Response from Mucosal gammadelta T Cells.";
RL   Immunity 47:148-158(2017).
CC   -!- FUNCTION: Effector cytokine of innate and adaptive immune system
CC       involved in antimicrobial host defense and maintenance of tissue
CC       integrity (PubMed:18025225, PubMed:19144317, PubMed:26431948). Signals
CC       via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic
CC       interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This
CC       leads to downstream TRAF6-mediated activation of NF-kappa-B and
CC       MAPkinase pathways ultimately resulting in transcriptional activation
CC       of cytokines, chemokines, antimicrobial peptides and matrix
CC       metalloproteinases, with potential strong immune inflammation
CC       (PubMed:17911633, PubMed:16200068, PubMed:19144317, PubMed:26431948).
CC       Plays an important role in connecting T cell-mediated adaptive immunity
CC       and acute inflammatory response to destroy extracellular bacteria and
CC       fungi. As a signature effector cytokine of T-helper 17 cells (Th17),
CC       primarily induces neutrophil activation and recruitment at infection
CC       and inflammatory sites (PubMed:18025225). In airway epithelium,
CC       mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5
CC       chemokines (PubMed:18025225, PubMed:27923703). In secondary lymphoid
CC       organs, contributes to germinal center formation by regulating the
CC       chemotactic response of B cells to CXCL12 and CXCL13, enhancing
CC       retention of B cells within the germinal centers, B cell somatic
CC       hypermutation rate and selection toward plasma cells (PubMed:18157131).
CC       Effector cytokine of a subset of gamma-delta T cells that functions as
CC       part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B
CC       to promote neutrophil recruitment for efficient bacterial clearance
CC       (PubMed:17372004, PubMed:20364087, PubMed:28709803). Effector cytokine
CC       of innate immune cells including invariant natural killer cell (iNKT)
CC       and group 3 innate lymphoid cells that mediate initial neutrophilic
CC       inflammation (PubMed:17470641, PubMed:23255360). Involved in the
CC       maintenance of the integrity of epithelial barriers during homeostasis
CC       and pathogen infection. Upon acute injury, has a direct role in
CC       epithelial barrier formation by regulating OCLN localization and tight
CC       junction biogenesis (PubMed:26431948). As part of the mucosal immune
CC       response induced by commensal bacteria, enhances host's ability to
CC       resist pathogenic bacterial and fungal infections by promoting
CC       neutrophil recruitment and antimicrobial peptides release
CC       (PubMed:28709803). In synergy with IL17F, mediates the production of
CC       antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal
CC       epithelial cells, limiting the entry of microbes through the epithelial
CC       barriers (PubMed:19144317). Involved in antiviral host defense through
CC       various mechanisms (PubMed:21946434, PubMed:26735852, PubMed:27795421).
CC       Enhances immunity against West Nile virus by promoting T cell
CC       cytotoxicity (PubMed:27795421). May play a beneficial role in influenza
CC       A virus (H5N1) infection by enhancing B cell recruitment and immune
CC       response in the lung (PubMed:21946434). Contributes to influenza A
CC       virus (H1N1) clearance by driving the differentiation of B-1a B cells,
CC       providing for production of virus-specific IgM antibodies at first line
CC       of host defense (PubMed:26735852). {ECO:0000269|PubMed:16200068,
CC       ECO:0000269|PubMed:17372004, ECO:0000269|PubMed:17470641,
CC       ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18025225,
CC       ECO:0000269|PubMed:18157131, ECO:0000269|PubMed:19144317,
CC       ECO:0000269|PubMed:20364087, ECO:0000269|PubMed:21946434,
CC       ECO:0000269|PubMed:23255360, ECO:0000269|PubMed:26431948,
CC       ECO:0000269|PubMed:26735852, ECO:0000269|PubMed:27795421,
CC       ECO:0000269|PubMed:27923703, ECO:0000269|PubMed:28709803}.
CC   -!- SUBUNIT: Homodimer (PubMed:18025225). Forms complexes with IL17RA and
CC       IL17RC receptors with 2:1 binding stoichiometry: two receptor chains
CC       for one interleukin molecule (By similarity). IL17A homodimer
CC       preferentially drives the formation of IL17RA-IL17RC heterodimeric
CC       receptor complex (By similarity). IL17A homodimer adopts an
CC       asymmetrical ternary structure with one IL17RA molecule, allowing for
CC       high affinity interactions of one IL17A monomer with one IL17RA
CC       molecule (via D1 and D2 domains), while disfavoring binding of a second
CC       IL17RA molecule on the other IL17A monomer (By similarity). Heterodimer
CC       with IL17F (PubMed:18025225). IL17A-IL17F forms complexes with IL17RA-
CC       IL17RC, but with lower affinity when compared to IL17A homodimer (By
CC       similarity). IL17RA and IL17RC chains cannot distinguish between IL17A
CC       and IL17F molecules, potentially enabling the formation of
CC       topologically distinct complexes (By similarity).
CC       {ECO:0000250|UniProtKB:Q16552, ECO:0000269|PubMed:18025225}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18025225}.
CC   -!- TISSUE SPECIFICITY: Expressed by Th17 cell lineage (at protein level).
CC       The expression pattern reflects the differentiation state, with IL17A-
CC       IL17F heterodimers produced at higher levels than IL17A-IL17A and
CC       IL17F-IL17F dimers in fully differentiated Th17 cells (PubMed:18025225,
CC       PubMed:16990136). Expressed in innate lymphoid cells (at protein level)
CC       (PubMed:23255360, PubMed:28709803). Expressed in gamma-delta T cell
CC       subsets (at protein level) (PubMed:17372004, PubMed:20364087,
CC       PubMed:28709803, PubMed:26431948). Expressed in iNKT cells (at protein
CC       level) (PubMed:17470641). {ECO:0000269|PubMed:16990136,
CC       ECO:0000269|PubMed:17372004, ECO:0000269|PubMed:17470641,
CC       ECO:0000269|PubMed:18025225, ECO:0000269|PubMed:20364087,
CC       ECO:0000269|PubMed:23255360, ECO:0000269|PubMed:26431948,
CC       ECO:0000269|PubMed:28709803}.
CC   -!- INDUCTION: Induced upon differentiation of CD4-positive T cells toward
CC       Th17 effector cells upon antigen receptor binding in the presence of
CC       IL6 and TGFB1 (PubMed:16200068, PubMed:16990136, PubMed:18025225). Up-
CC       regulated by IL23A-IL12B, IL1B and TNF and inhibited by IFNG and IL4
CC       (PubMed:16200068, PubMed:18025225). Up-regulated by pro-inflammatory
CC       cytokines in response to microbes in various immune cells: induced in
CC       innate lymphoid cells upon fungal infection, in Vdelta4-positive gamma-
CC       delta T cells upon C. mastitidis infection, in Vdelta5-positive gamma-
CC       delta T cells upon S. aureus infection and in Vdelta1-positive gamma-
CC       delta T cells upon E. coli infection (PubMed:23255360, PubMed:28709803,
CC       PubMed:20364087, PubMed:17372004). Induced in gamma-delta T cells in
CC       intestinal lamina propria upon acute injury (PubMed:26431948). Induced
CC       in KLRB1/NK1.1-negative iNKT cell subset upon CD1D stimulation
CC       (PubMed:17470641). {ECO:0000269|PubMed:16200068,
CC       ECO:0000269|PubMed:16990136, ECO:0000269|PubMed:17372004,
CC       ECO:0000269|PubMed:17470641, ECO:0000269|PubMed:18025225,
CC       ECO:0000269|PubMed:20364087, ECO:0000269|PubMed:23255360,
CC       ECO:0000269|PubMed:26431948, ECO:0000269|PubMed:28709803}.
CC   -!- DISRUPTION PHENOTYPE: Mutant mice are born at the expected Mendelian
CC       ratio, are fertile, and have no apparent phenotypic abnormalities. They
CC       are protected against chronic autoimmune and allergic reactions, as
CC       observed in models of spontaneous or induced rheumatoid arthritis,
CC       experimental autoimmune encephalomyelitis and chemical allergen-induced
CC       contact hypersensitivity (PubMed:19144317). In a model of acute
CC       intestinal injury, mutant mice show epithelial disruption, presence of
CC       abscesses associated with enhanced bleeding into the mucosal lumen and
CC       increased cellular infiltrate into the submucosal layer
CC       (PubMed:26431948). Mutant mice show increased susceptibility to West
CC       Nile virus infection characterized by deficient virus clearance from
CC       brain and spleen (PubMed:27795421). Mutant mice are deficient in
CC       clearing influenza A virus (H1N1) pulmonary infection due to increased
CC       immune inflammation and lung damage (PubMed:26735852).
CC       {ECO:0000269|PubMed:19144317, ECO:0000269|PubMed:26431948,
CC       ECO:0000269|PubMed:26735852, ECO:0000269|PubMed:27795421}.
CC   -!- SIMILARITY: Belongs to the IL-17 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U43088; AAB05222.1; -; mRNA.
DR   EMBL; U35108; AAA93253.1; -; Genomic_DNA.
DR   CCDS; CCDS14842.1; -.
DR   PIR; JC4628; JC4628.
DR   RefSeq; NP_034682.1; NM_010552.3.
DR   AlphaFoldDB; Q62386; -.
DR   SMR; Q62386; -.
DR   IntAct; Q62386; 2.
DR   STRING; 10090.ENSMUSP00000027061; -.
DR   GlyGen; Q62386; 1 site.
DR   PhosphoSitePlus; Q62386; -.
DR   PaxDb; Q62386; -.
DR   PRIDE; Q62386; -.
DR   Antibodypedia; 17132; 1912 antibodies from 50 providers.
DR   DNASU; 16171; -.
DR   Ensembl; ENSMUST00000027061; ENSMUSP00000027061; ENSMUSG00000025929.
DR   GeneID; 16171; -.
DR   KEGG; mmu:16171; -.
DR   UCSC; uc007aky.1; mouse.
DR   CTD; 3605; -.
DR   MGI; MGI:107364; Il17a.
DR   VEuPathDB; HostDB:ENSMUSG00000025929; -.
DR   eggNOG; ENOG502S5A0; Eukaryota.
DR   GeneTree; ENSGT00940000161882; -.
DR   HOGENOM; CLU_118641_0_0_1; -.
DR   InParanoid; Q62386; -.
DR   OMA; HHMNSVP; -.
DR   OrthoDB; 1469254at2759; -.
DR   PhylomeDB; Q62386; -.
DR   TreeFam; TF314701; -.
DR   BioGRID-ORCS; 16171; 2 hits in 76 CRISPR screens.
DR   PRO; PR:Q62386; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q62386; protein.
DR   Bgee; ENSMUSG00000025929; Expressed in lumbar subsegment of spinal cord and 10 other tissues.
DR   ExpressionAtlas; Q62386; baseline and differential.
DR   Genevisible; Q62386; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0071385; P:cellular response to glucocorticoid stimulus; ISO:MGI.
DR   GO; GO:0071347; P:cellular response to interleukin-1; IDA:MGI.
DR   GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0072537; P:fibroblast activation; ISO:MGI.
DR   GO; GO:0097530; P:granulocyte migration; IGI:ARUK-UCL.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0097400; P:interleukin-17-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0060729; P:intestinal epithelial structure maintenance; IMP:UniProtKB.
DR   GO; GO:0007219; P:Notch signaling pathway; IDA:MGI.
DR   GO; GO:0002225; P:positive regulation of antimicrobial peptide production; IDA:UniProtKB.
DR   GO; GO:1903348; P:positive regulation of bicellular tight junction assembly; IMP:UniProtKB.
DR   GO; GO:2000340; P:positive regulation of chemokine (C-X-C motif) ligand 1 production; IDA:UniProtKB.
DR   GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IDA:MGI.
DR   GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISO:MGI.
DR   GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:MGI.
DR   GO; GO:0032739; P:positive regulation of interleukin-16 production; ISO:MGI.
DR   GO; GO:0032747; P:positive regulation of interleukin-23 production; ISO:MGI.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; IMP:UniProtKB.
DR   GO; GO:0010940; P:positive regulation of necrotic cell death; ISO:MGI.
DR   GO; GO:0045672; P:positive regulation of osteoclast differentiation; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:MGI.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020440; IL-17_chr.
DR   InterPro; IPR010345; IL-17_fam.
DR   Pfam; PF06083; IL17; 1.
DR   PRINTS; PR01932; INTRLEUKIN17.
DR   SUPFAM; SSF57501; SSF57501; 1.
PE   1: Evidence at protein level;
KW   Adaptive immunity; Cytokine; Disulfide bond; Glycoprotein; Immunity;
KW   Inflammatory response; Innate immunity; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..158
FT                   /note="Interleukin-17A"
FT                   /id="PRO_0000015424"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..147
FT                   /evidence="ECO:0000250"
FT   DISULFID        102..149
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   158 AA;  17490 MW;  3505C143435F4653 CRC64;
     MSPGRASSVS LMLLLLLSLA ATVKAAAIIP QSSACPNTEA KDFLQNVKVN LKVFNSLGAK
     VSSRRPSDYL NRSTSPWTLH RNEDPDRYPS VIWEAQCRHQ RCVNAEGKLD HHMNSVLIQQ
     EILVLKREPE SCPFTFRVEK MLVGVGCTCV ASIVRQAA
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024