ID   IL18B_VACCW             Reviewed;         126 AA.
AC   P17357; Q80HY7;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Interleukin-18-binding protein;
DE            Short=vIL-18BP;
DE   Flags: Precursor;
GN   Name=VACWR013;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2849238; DOI=10.1016/s0042-6822(88)90115-8;
RA   Kotwal G.J., Moss B.;
RT   "Analysis of a large cluster of nonessential genes deleted from a vaccinia
RT   virus terminal transposition mutant.";
RL   Virology 167:524-537(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RC   STRAIN=Lister;
RX   PubMed=10769064; DOI=10.1099/0022-1317-81-5-1223;
RA   Smith V.P., Bryant N.A., Alcami A.;
RT   "Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-
RT   binding proteins.";
RL   J. Gen. Virol. 81:1223-1230(2000).
CC   -!- FUNCTION: Soluble IL18-binding protein that may modulate the host
CC       antiviral response. {ECO:0000269|PubMed:10769064}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA69593.1; Type=Miscellaneous discrepancy; Note=Truncated.; Evidence={ECO:0000305};
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DR   EMBL; M22812; AAA69593.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AY243312; AAO89292.1; -; Genomic_DNA.
DR   PIR; B31829; WZVZA2.
DR   RefSeq; YP_232895.1; NC_006998.1.
DR   SMR; P17357; -.
DR   DNASU; 3707628; -.
DR   GeneID; 3707628; -.
DR   KEGG; vg:3707628; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008791; Orthopox_IL18-bd.
DR   Pfam; PF05566; Pox_vIL-18BP; 1.
PE   3: Inferred from homology;
KW   Early protein; Host-virus interaction; Reference proteome; Secreted;
KW   Signal; Viral immunoevasion.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..126
FT                   /note="Interleukin-18-binding protein"
FT                   /id="PRO_0000099740"
SQ   SEQUENCE   126 AA;  14546 MW;  A9A875111ED16B78 CRC64;
     MRILFLIAFM YGCVHPYVNA DEIKCPNLNI VTSSGEFRCT GCVKFMPNFS YMYWLAKDMR
     SDEDAKFIEH LGEGIKEDET VSTIDGRIVT LQKVLHVTDT NKFDNYRFTC VLTTIDGVSK
     KNIWLK