ID   IL18_CHICK              Reviewed;         196 AA.
AC   Q8QFQ8;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Interleukin-18;
DE            Short=IL-18;
DE   Flags: Precursor;
GN   Name=IL18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rothwell L., Buerstedde J.-M., Kaiser P.;
RT   "Cloning and characterisation of chicken interleukin-18.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Augments natural killer cell activity in spleen cells and
CC       stimulates interferon gamma production in T-helper type I cells.
CC       Involved in transduction of inflammation downstream of pyroptosis: its
CC       mature form is specifically released in the extracellular milieu by
CC       passing through the gasdermin-D (GSDMD) pore.
CC       {ECO:0000250|UniProtKB:Q14116}.
CC   -!- SUBUNIT: Forms a ternary complex with ligand-binding receptor subunit
CC       IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane.
CC       Mature IL18 first binds to IL18R1 forming a low affinity binary
CC       complex, which then interacts with IL18RAP to form a high affinity
CC       ternary complex that signals inside the cell. Interacts with cargo
CC       receptor TMED10; the interaction mediates the translocation from the
CC       cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate
CC       compartment) and thereby secretion. {ECO:0000250|UniProtKB:Q14116}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14116}.
CC       Secreted {ECO:0000250|UniProtKB:Q14116}. Note=The precursor is
CC       cytosolic. In response to inflammasome-activating signals, cleaved and
CC       secreted. Mature form is secreted and released in the extracellular
CC       milieu by passing through the gasdermin-D (GSDMD) pore. In contrast,
CC       the precursor form is not released, due to the presence of an acidic
CC       region that is proteolytically removed by CASP1 during maturation. The
CC       secretion is dependent on protein unfolding and facilitated by the
CC       cargo receptor TMED10. {ECO:0000250|UniProtKB:Q14116}.
CC   -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield
CC       the active form. {ECO:0000250|UniProtKB:Q14116}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; AJ276025; CAC81652.1; -; mRNA.
DR   AlphaFoldDB; Q8QFQ8; -.
DR   SMR; Q8QFQ8; -.
DR   STRING; 9031.ENSGALP00000012772; -.
DR   PaxDb; Q8QFQ8; -.
DR   PRIDE; Q8QFQ8; -.
DR   VEuPathDB; HostDB:geneid_395312; -.
DR   eggNOG; ENOG502SDJZ; Eukaryota.
DR   InParanoid; Q8QFQ8; -.
DR   OrthoDB; 1164635at2759; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0035710; P:CD4-positive, alpha-beta T cell activation; IDA:AgBase.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0061436; P:establishment of skin barrier; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:0035655; P:interleukin-18-mediated signaling pathway; ISS:UniProtKB.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:AgBase.
DR   GO; GO:0050671; P:positive regulation of lymphocyte proliferation; IDA:AgBase.
DR   InterPro; IPR015529; IL-18.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   Pfam; PF00340; IL1; 1.
DR   PIRSF; PIRSF015162; Interleukin_18; 1.
DR   PRINTS; PR01933; INTRLEUKIN18.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Cytoplasm; Reference proteome; Secreted.
FT   PROPEP          1..29
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000015351"
FT   CHAIN           30..196
FT                   /note="Interleukin-18"
FT                   /id="PRO_0000015352"
SQ   SEQUENCE   196 AA;  22787 MW;  4947DECECCB92414 CRC64;
     MSCEEIAVCA VRLRENLCLY FEELECDAFC KDKTIKRFFR NVNSQLLVVR PDLNVAAFED
     VTDQEVKSGS GMYFDIHCYK TTAPSARMPV AFSVQVEDKS YYMCCEKEHG KMVVRFREGE
     VPKDIPGESN IIFFKKTFTS CSSKAFKFEY SLEQGMFLAF EEEDSLRKLI LKKLPREDEV
     DETTKFVTSH NERHNL