IL18_FELCA
ID IL18_FELCA Reviewed; 192 AA.
AC Q95M33; Q865B8;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Interleukin-18;
DE Short=IL-18;
DE AltName: Full=Interferon gamma-inducing factor;
DE Short=IFN-gamma-inducing factor;
DE AltName: Full=Interleukin-1 gamma;
DE Short=IL-1 gamma;
DE Flags: Precursor;
GN Name=IL18; Synonyms=IGIF;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Alveolar macrophage;
RA Hanlon L., McGillivray C.P., Argyle D.J.A., Nicolson L., Onions D.E.;
RT "Nucleotide sequence of feline IGIF cDNA.";
RL Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kuwahara C., Kawakami K., Kishi M., Mochizuki M.;
RT "Feline interleukin-18.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Lymphocyte;
RA Qiao J., Xia X., Yang S.;
RT "Cloning and sequence analysis of feline IL-18 gene.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Pro-inflammatory cytokine primarily involved in epithelial
CC barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK)
CC cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a
CC signaling ternary complex which activates NF-kappa-B, triggering
CC synthesis of inflammatory mediators. Synergizes with IL12/interleukin-
CC 12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural
CC killer (NK) cells. Involved in transduction of inflammation downstream
CC of pyroptosis: its mature form is specifically released in the
CC extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
CC {ECO:0000250|UniProtKB:Q14116}.
CC -!- SUBUNIT: Forms a ternary complex with ligand-binding receptor subunit
CC IL18R1 and signaling receptor subunit IL18RAP at the plasma membrane.
CC Mature IL18 first binds to IL18R1 forming a low affinity binary
CC complex, which then interacts with IL18RAP to form a high affinity
CC ternary complex that signals inside the cell. Interacts with cargo
CC receptor TMED10; the interaction mediates the translocation from the
CC cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate
CC compartment) and thereby secretion. {ECO:0000250|UniProtKB:Q14116}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14116}.
CC Secreted {ECO:0000250|UniProtKB:Q14116}. Note=The precursor is
CC cytosolic. In response to inflammasome-activating signals, cleaved and
CC secreted. Mature form is secreted and released in the extracellular
CC milieu by passing through the gasdermin-D (GSDMD) pore. In contrast,
CC the precursor form is not released, due to the presence of an acidic
CC region that is proteolytically removed by CASP1 during maturation. The
CC secretion is dependent on protein unfolding and facilitated by the
CC cargo receptor TMED10. {ECO:0000250|UniProtKB:Q14116}.
CC -!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield
CC the active form. {ECO:0000250|UniProtKB:Q14116}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR EMBL; Y13923; CAC42918.1; -; mRNA.
DR EMBL; AB056857; BAC65243.1; -; mRNA.
DR EMBL; DQ100372; AAY96319.1; -; mRNA.
DR RefSeq; NP_001009213.2; NM_001009213.2.
DR AlphaFoldDB; Q95M33; -.
DR SMR; Q95M33; -.
DR STRING; 9685.ENSFCAP00000017529; -.
DR GeneID; 493688; -.
DR KEGG; fca:493688; -.
DR CTD; 3606; -.
DR eggNOG; ENOG502SDJZ; Eukaryota.
DR InParanoid; Q95M33; -.
DR OrthoDB; 1190337at2759; -.
DR Proteomes; UP000011712; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR GO; GO:0045515; F:interleukin-18 receptor binding; ISS:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR GO; GO:0061436; P:establishment of skin barrier; ISS:UniProtKB.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0035655; P:interleukin-18-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; ISS:UniProtKB.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR GO; GO:2000556; P:positive regulation of T-helper 1 cell cytokine production; ISS:UniProtKB.
DR InterPro; IPR015529; IL-18.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR008996; IL1/FGF.
DR Pfam; PF00340; IL1; 1.
DR PIRSF; PIRSF015162; Interleukin_18; 1.
DR PRINTS; PR01933; INTRLEUKIN18.
DR SUPFAM; SSF50353; SSF50353; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Cytoplasm; Inflammatory response; Reference proteome; Secreted.
FT PROPEP 1..35
FT /evidence="ECO:0000250|UniProtKB:P70380"
FT /id="PRO_0000252354"
FT CHAIN 36..192
FT /note="Interleukin-18"
FT /id="PRO_0000252355"
FT CONFLICT 4
FT /note="I -> E (in Ref. 2; BAC65243)"
FT /evidence="ECO:0000305"
FT CONFLICT 7
FT /note="D -> E (in Ref. 2; BAC65243)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="N -> S (in Ref. 2; BAC65243)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 192 AA; 22068 MW; 5878C3DAC7A43358 CRC64;
MAAIPVDDCI NFVGMKFIDN TLYFVADSDE NLETDYFGKL EHKLSILRNL NDQVLFINQG
DQPVFEDMPD SDCTDNAPRT EFIIYMYKDS LTRGLAVTIS VNYKTMSTLS CENKIISFKE
MSPPESINDE GNDIIFFQRS VPGHDDKIQF ESSLYKGYFL ACEKEKDLFK LILKKKDENG
DKSIMFTVQN KN
