IL19_MOUSE
ID IL19_MOUSE Reviewed; 176 AA.
AC Q8CJ70;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Interleukin-19;
DE Short=IL-19;
DE Flags: Precursor;
GN Name=Il19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Swiss Webster / NIH;
RX PubMed=12370360; DOI=10.4049/jimmunol.169.8.4288;
RA Liao Y.-C., Liang W.G., Chen F.W., Hsu J.H., Yang J.J., Chang M.-S.;
RT "IL-19 induces production of IL-6 and TNF-alpha and results in cell
RT apoptosis through TNF-alpha.";
RL J. Immunol. 169:4288-4297(2002).
CC -!- FUNCTION: May play some important roles in inflammatory responses. Up-
CC regulates IL-6 and TNF-alpha and induces apoptosis.
CC {ECO:0000269|PubMed:12370360}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
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DR EMBL; AF453945; AAN40905.1; -; mRNA.
DR CCDS; CCDS15264.1; -.
DR RefSeq; NP_001009940.1; NM_001009940.1.
DR RefSeq; XP_006529769.1; XM_006529706.1.
DR AlphaFoldDB; Q8CJ70; -.
DR SMR; Q8CJ70; -.
DR STRING; 10090.ENSMUSP00000108084; -.
DR GlyGen; Q8CJ70; 3 sites.
DR PaxDb; Q8CJ70; -.
DR PRIDE; Q8CJ70; -.
DR ProteomicsDB; 267233; -.
DR Antibodypedia; 34588; 399 antibodies from 31 providers.
DR DNASU; 329244; -.
DR Ensembl; ENSMUST00000016668; ENSMUSP00000016668; ENSMUSG00000016524.
DR Ensembl; ENSMUST00000112465; ENSMUSP00000108084; ENSMUSG00000016524.
DR Ensembl; ENSMUST00000187410; ENSMUSP00000139406; ENSMUSG00000016524.
DR GeneID; 329244; -.
DR KEGG; mmu:329244; -.
DR UCSC; uc007cms.1; mouse.
DR CTD; 29949; -.
DR MGI; MGI:1890472; Il19.
DR VEuPathDB; HostDB:ENSMUSG00000016524; -.
DR eggNOG; ENOG502SRCR; Eukaryota.
DR GeneTree; ENSGT00950000183124; -.
DR HOGENOM; CLU_098690_0_0_1; -.
DR InParanoid; Q8CJ70; -.
DR OMA; LYMQKAL; -.
DR OrthoDB; 1267998at2759; -.
DR PhylomeDB; Q8CJ70; -.
DR TreeFam; TF333253; -.
DR BioGRID-ORCS; 329244; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8CJ70; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q8CJ70; protein.
DR Bgee; ENSMUSG00000016524; Expressed in yolk sac and 7 other tissues.
DR ExpressionAtlas; Q8CJ70; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IDA:MGI.
DR GO; GO:0010989; P:negative regulation of low-density lipoprotein particle clearance; IMP:BHF-UCL.
DR GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IDA:MGI.
DR GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IGI:MGI.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; IDA:MGI.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR InterPro; IPR020423; IL-10_CS.
DR InterPro; IPR020421; IL-19.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01934; INTRLEUKIN19.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytokine; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..176
FT /note="Interleukin-19"
FT /id="PRO_0000015380"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 28..120
FT /evidence="ECO:0000250"
FT DISULFID 74..126
FT /evidence="ECO:0000250"
FT DISULFID 75..128
FT /evidence="ECO:0000250"
SQ SEQUENCE 176 AA; 20288 MW; 73E6C1BC54077FDC CRC64;
MKTQCASTWL LGMTLILCSV HIYSLRRCLI SVDMRLIEKS FHEIKRAMQT KDTFKNVTIL
SLENLRSIKP GDVCCMTNNL LTFYRDRVFQ DHQERSLEVL RRISSIANSF LCVQKSLERC
QVHRQCNCSQ EATNATRIIH DNYNQLEVSS AALKSLGELN ILLAWIDRNH LETPAA
