ID   4EB3L_DANRE             Reviewed;         112 AA.
AC   Q98TT6;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Eukaryotic translation initiation factor 4E-binding protein 3-like;
DE            Short=4E-BP3;
DE            Short=eIF4E-binding protein 3;
DE   AltName: Full=Eukaryotic translation initiation factor 4E-1A-binding protein;
DE            Short=4E-BP;
DE            Short=eIF4E-1A-binding protein;
GN   Name=eif4ebp3l; Synonyms=eif4ebp3; ORFNames=zgc:56330;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAG50053.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH EIF4E1A.
RX   PubMed=14701818; DOI=10.1074/jbc.m313688200;
RA   Robalino J., Joshi B., Fahrenkrug S.C., Jagus R.;
RT   "Two zebrafish eIF4E family members are differentially expressed and
RT   functionally divergent.";
RL   J. Biol. Chem. 279:10532-10541(2004).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAH46079.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30; THR-42 AND THR-46, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA   Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT   analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- FUNCTION: Regulates eif4e1a activity by preventing its assembly into
CC       the eIF4F complex. {ECO:0000250|UniProtKB:O60516}.
CC   -!- SUBUNIT: Interacts with eif4e1a. {ECO:0000269|PubMed:14701818}.
CC   -!- SIMILARITY: Belongs to the eIF4E-binding protein family. {ECO:0000305}.
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DR   EMBL; AF332983; AAG50053.1; -; mRNA.
DR   EMBL; BC046079; AAH46079.1; -; mRNA.
DR   RefSeq; NP_955977.1; NM_199683.1.
DR   AlphaFoldDB; Q98TT6; -.
DR   SMR; Q98TT6; -.
DR   STRING; 7955.ENSDARP00000060989; -.
DR   iPTMnet; Q98TT6; -.
DR   PaxDb; Q98TT6; -.
DR   Ensembl; ENSDART00000060990; ENSDARP00000060989; ENSDARG00000041607.
DR   GeneID; 324490; -.
DR   KEGG; dre:324490; -.
DR   CTD; 324490; -.
DR   ZFIN; ZDB-GENE-030826-26; eif4ebp3l.
DR   eggNOG; ENOG502S03G; Eukaryota.
DR   GeneTree; ENSGT00940000163328; -.
DR   HOGENOM; CLU_111706_0_0_1; -.
DR   InParanoid; Q98TT6; -.
DR   OMA; DDEQFGM; -.
DR   OrthoDB; 1597535at2759; -.
DR   PhylomeDB; Q98TT6; -.
DR   TreeFam; TF101530; -.
DR   PRO; PR:Q98TT6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 14.
DR   Bgee; ENSDARG00000041607; Expressed in early embryo and 52 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008190; F:eukaryotic initiation factor 4E binding; IBA:GO_Central.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IBA:GO_Central.
DR   GO; GO:0014743; P:regulation of muscle hypertrophy; IMP:ZFIN.
DR   InterPro; IPR008606; EIF4EBP.
DR   Pfam; PF05456; eIF_4EBP; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Protein synthesis inhibitor; Reference proteome;
KW   Translation regulation.
FT   CHAIN           1..112
FT                   /note="Eukaryotic translation initiation factor 4E-binding
FT                   protein 3-like"
FT                   /id="PRO_0000190520"
FT   MOD_RES         30
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
FT   MOD_RES         42
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
FT   MOD_RES         46
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
SQ   SEQUENCE   112 AA;  12531 MW;  F71BEA295722826E CRC64;
     MSTNTQQSKS CPIPTRVLHL KDWSQLPDCY SQTPGGTLFS TTPGGTRIIY DRKFLLDCRN
     SPIARTPPCC LPQIPGVTIP SLHPVSKLQE LKEELEEEKE LAADDSQFEM DI