IL1FA_MOUSE
ID IL1FA_MOUSE Reviewed; 152 AA.
AC Q8R459;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Interleukin-1 family member 10;
DE Short=IL-1F10;
GN Name=Il1f10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster / NIH;
RX PubMed=11991723; DOI=10.1006/geno.2002.6752;
RA Taylor S.L., Renshaw B.R., Garka K.E., Smith D.E., Sims J.E.;
RT "Genomic organization of the interleukin-1 locus.";
RL Genomics 79:726-733(2002).
CC -!- FUNCTION: Cytokine with immunomodulatory activity. Alone, does not
CC induce cytokine production, but reduces IL22 and IL17A production by T-
CC cells in response to heat-killed Candida albicans. Reduces IL36G-
CC induced production of IL8 by peripheral blood mononuclear cells.
CC Increases IL6 production by dendritic cells stimulated by bacterial
CC lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2 (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with cargo receptor TMED10; the interaction mediates
CC the translocation from the cytoplasm into the ERGIC (endoplasmic
CC reticulum-Golgi intermediate compartment) and thereby secretion.
CC {ECO:0000250|UniProtKB:Q8WWZ1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8WWZ1}.
CC Endoplasmic reticulum-Golgi intermediate compartment
CC {ECO:0000250|UniProtKB:Q8WWZ1}. Secreted
CC {ECO:0000250|UniProtKB:Q8WWZ1}. Note=The secretion is dependent on
CC protein unfolding and facilitated by the cargo receptor TMED10; it
CC results in protein translocation from the cytoplasm into the ERGIC
CC (endoplasmic reticulum-Golgi intermediate compartment) followed by
CC vesicle entry and secretion. {ECO:0000250|UniProtKB:Q8WWZ1}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR EMBL; AY071844; AAL67155.1; -; mRNA.
DR CCDS; CCDS15735.1; -.
DR RefSeq; NP_694717.1; NM_153077.2.
DR AlphaFoldDB; Q8R459; -.
DR SMR; Q8R459; -.
DR STRING; 10090.ENSMUSP00000063004; -.
DR PhosphoSitePlus; Q8R459; -.
DR PaxDb; Q8R459; -.
DR PRIDE; Q8R459; -.
DR ProteomicsDB; 269392; -.
DR Antibodypedia; 47548; 195 antibodies from 27 providers.
DR DNASU; 215274; -.
DR Ensembl; ENSMUST00000058056; ENSMUSP00000063004; ENSMUSG00000046845.
DR GeneID; 215274; -.
DR KEGG; mmu:215274; -.
DR UCSC; uc008iou.1; mouse.
DR CTD; 84639; -.
DR MGI; MGI:2652548; Il1f10.
DR VEuPathDB; HostDB:ENSMUSG00000046845; -.
DR eggNOG; ENOG502SN3A; Eukaryota.
DR GeneTree; ENSGT00950000182943; -.
DR HOGENOM; CLU_095373_2_0_1; -.
DR InParanoid; Q8R459; -.
DR OMA; QFYFEQS; -.
DR OrthoDB; 1410755at2759; -.
DR PhylomeDB; Q8R459; -.
DR TreeFam; TF300203; -.
DR Reactome; R-MMU-9007892; Interleukin-38 signaling.
DR Reactome; R-MMU-9014826; Interleukin-36 pathway.
DR BioGRID-ORCS; 215274; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8R459; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8R459; protein.
DR Bgee; ENSMUSG00000046845; Expressed in lip and 7 other tissues.
DR ExpressionAtlas; Q8R459; baseline and differential.
DR Genevisible; Q8R459; MM.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005149; F:interleukin-1 receptor binding; IEA:InterPro.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR InterPro; IPR027164; IL-1_F10.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR003297; IL-1RA/IL-36.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR10078; PTHR10078; 1.
DR PANTHER; PTHR10078:SF29; PTHR10078:SF29; 1.
DR Pfam; PF00340; IL1; 1.
DR PRINTS; PR00264; INTERLEUKIN1.
DR PRINTS; PR01360; INTRLEUKIN1X.
DR SUPFAM; SSF50353; SSF50353; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Cytoplasm; Reference proteome; Secreted.
FT CHAIN 1..152
FT /note="Interleukin-1 family member 10"
FT /id="PRO_0000153651"
SQ SEQUENCE 152 AA; 17078 MW; 9AD03EB0C3C61D8A CRC64;
MCSLPMARYY IIKDAHQKAL YTRNGQLLLG DPDSDNYSPE KVCILPNRGL DRSKVPIFLG
MQGGSCCLAC VKTREGPLLQ LEDVNIEDLY KGGEQTTRFT FFQRSLGSAF RLEAAACPGW
FLCGPAEPQQ PVQLTKESEP STHTEFYFEM SR
