ID   IL1RA_BOVIN             Reviewed;         174 AA.
AC   O77482;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9643454; DOI=10.1016/s0165-2427(98)00099-3;
RA   Kirisawa R., Fukuda T., Yamanaka H., Hagiwara K., Goto M., Obata Y.,
RA   Yoshino T., Iwai H.;
RT   "Enzymatic amplification and expression of bovine interleukin-1 receptor
RT   antagonist cDNA.";
RL   Vet. Immunol. Immunopathol. 62:197-208(1998).
CC   -!- FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of
CC       proinflammatory cytokines such as interleukin-1beta/IL1B and
CC       interleukin-1alpha/IL1A. Protects from immune dysregulation and
CC       uncontrolled systemic inflammation triggered by IL1 for a range of
CC       innate stimulatory agents such as pathogens.
CC       {ECO:0000250|UniProtKB:P25085}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18510}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; AB005148; BAA31854.1; -; mRNA.
DR   RefSeq; NP_776782.1; NM_174357.3.
DR   AlphaFoldDB; O77482; -.
DR   SMR; O77482; -.
DR   STRING; 9913.ENSBTAP00000026209; -.
DR   PaxDb; O77482; -.
DR   PeptideAtlas; O77482; -.
DR   PRIDE; O77482; -.
DR   GeneID; 281860; -.
DR   KEGG; bta:281860; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG502S5F0; Eukaryota.
DR   HOGENOM; CLU_095373_2_0_1; -.
DR   InParanoid; O77482; -.
DR   OrthoDB; 1410755at2759; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0002437; P:inflammatory response to antigenic stimulus; IBA:GO_Central.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR008996; IL1/FGF.
DR   InterPro; IPR039348; IL1RA.
DR   PANTHER; PTHR10078; PTHR10078; 1.
DR   PANTHER; PTHR10078:SF28; PTHR10078:SF28; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   CHAIN           24..174
FT                   /note="Interleukin-1 receptor antagonist protein"
FT                   /id="PRO_0000015325"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        89..139
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   174 AA;  19926 MW;  1E56E7F224FF851F CRC64;
     MDIYIHGYLI CLLLFLFRSE TACHPLGKRR CEMQAFRIWD VNQKIFYLRN NQLVAGYLQG
     PNTKLEEKID VVPIEPHTMF LGIHGGKLCL ACVKSGDEIK LKLEAVNITD LNQNREQDKR
     FAFIRFDNGP TTSFESAACP GWFLCTSLEA DQPVGLTNMP TEALKVTKFY FQQD