ID   IL1RA_CANLF             Reviewed;         176 AA.
AC   Q9BEH0; Q9GKK2;
DT   15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Shin I.-S., Youn H.-Y.;
RT   "Molecular cloning of canine interleukin-1 receptor antagonist (IL-1ra).";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11182158; DOI=10.1016/s0165-2427(00)00261-0;
RA   Campbell S.E., Nasir L., Argyle D.J., Gault E.A., Duthie S., Bennett D.;
RT   "Cloning of canine IL-1ra, TNFR and TIMP-2.";
RL   Vet. Immunol. Immunopathol. 78:207-214(2001).
CC   -!- FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of
CC       proinflammatory cytokines such as interleukin-1beta/IL1B and
CC       interleukin-1alpha/IL1A. Protects from immune dysregulation and
CC       uncontrolled systemic inflammation triggered by IL1 for a range of
CC       innate stimulatory agents such as pathogens.
CC       {ECO:0000250|UniProtKB:P25085}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18510}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; AY026462; AAK01472.1; -; mRNA.
DR   EMBL; AF216526; AAG36777.1; -; mRNA.
DR   RefSeq; NP_001003096.1; NM_001003096.1.
DR   AlphaFoldDB; Q9BEH0; -.
DR   SMR; Q9BEH0; -.
DR   STRING; 9615.ENSCAFP00000036995; -.
DR   PaxDb; Q9BEH0; -.
DR   Ensembl; ENSCAFT00000104578; ENSCAFP00000073905; ENSCAFG00000007277.
DR   Ensembl; ENSCAFT00030010092; ENSCAFP00030008842; ENSCAFG00030005460.
DR   Ensembl; ENSCAFT00040025225; ENSCAFP00040021927; ENSCAFG00040013573.
DR   Ensembl; ENSCAFT00845021339; ENSCAFP00845016781; ENSCAFG00845011971.
DR   GeneID; 403660; -.
DR   KEGG; cfa:403660; -.
DR   CTD; 3557; -.
DR   VEuPathDB; HostDB:ENSCAFG00845011971; -.
DR   VGNC; VGNC:41962; IL1RN.
DR   eggNOG; ENOG502S5F0; Eukaryota.
DR   GeneTree; ENSGT00950000182943; -.
DR   HOGENOM; CLU_095373_2_0_1; -.
DR   InParanoid; Q9BEH0; -.
DR   OMA; WYLCTAL; -.
DR   OrthoDB; 1410755at2759; -.
DR   TreeFam; TF300203; -.
DR   Reactome; R-CFA-9020702; Interleukin-1 signaling.
DR   Proteomes; UP000002254; Chromosome 17.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:0045352; F:interleukin-1 type I receptor antagonist activity; IEA:Ensembl.
DR   GO; GO:0045353; F:interleukin-1 type II receptor antagonist activity; IEA:Ensembl.
DR   GO; GO:0005150; F:interleukin-1, type I receptor binding; IEA:Ensembl.
DR   GO; GO:0005151; F:interleukin-1, type II receptor binding; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0002437; P:inflammatory response to antigenic stimulus; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR008996; IL1/FGF.
DR   InterPro; IPR039348; IL1RA.
DR   PANTHER; PTHR10078; PTHR10078; 1.
DR   PANTHER; PTHR10078:SF28; PTHR10078:SF28; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..176
FT                   /note="Interleukin-1 receptor antagonist protein"
FT                   /id="PRO_0000015326"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        91..141
FT                   /evidence="ECO:0000250"
FT   CONFLICT        155
FT                   /note="P -> L (in Ref. 2; AAG36777)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   176 AA;  19922 MW;  8486CA54A240212B CRC64;
     METCRCPLSY LISFLLFLSH SETACRPLGK RPCRMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGSNTKLEEK LDVVPVEPHA VFLGIHGGKL CLACVKSGDE TRLQLEAVNI TDLSKNKDQD
     KRFTFILSDS GPTTSFESAA CPGWFLCTAL EADRPVSLTN RPEEAMMVTK FYFQKE