ID   IL1RA_HORSE             Reviewed;         177 AA.
AC   O18999; O77745; Q9TSJ0;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN; Synonyms=IL1RA;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9223227; DOI=10.1016/s0165-2427(96)05769-8;
RA   Kato H., Ohashi T., Matsushiro H., Watari T., Goitsuka R., Tsujimoto H.,
RA   Hasegawa A.;
RT   "Molecular cloning and functional expression of equine interleukin-1
RT   receptor antagonist.";
RL   Vet. Immunol. Immunopathol. 56:221-231(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9622739;
RA   Howard R.D., McIlwraith C.W., Trotter G.W., Nyborg J.K.;
RT   "Cloning of equine interleukin-1 receptor antagonist and determination of
RT   its full-length cDNA sequence.";
RL   Am. J. Vet. Res. 59:712-716(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-119.
RA   Dhar A.K., Thompson M.S., Paradis M.R., Alcivar-Warren A.;
RT   "Molecular characterization of equine interleukin 1 receptor antagonist
RT   (IL-1ra) gene.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of
CC       proinflammatory cytokines such as interleukin-1beta/IL1B and
CC       interleukin-1alpha/IL1A. Protects from immune dysregulation and
CC       uncontrolled systemic inflammation triggered by IL1 for a range of
CC       innate stimulatory agents such as pathogens.
CC       {ECO:0000250|UniProtKB:P25085}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18510}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; D83714; BAA22529.1; -; mRNA.
DR   EMBL; U92482; AAC39257.1; -; mRNA.
DR   EMBL; AF088186; AAD04132.1; -; mRNA.
DR   RefSeq; NP_001075994.1; NM_001082525.2.
DR   AlphaFoldDB; O18999; -.
DR   SMR; O18999; -.
DR   STRING; 9796.ENSECAP00000052943; -.
DR   PaxDb; O18999; -.
DR   PRIDE; O18999; -.
DR   Ensembl; ENSECAT00000068033; ENSECAP00000052943; ENSECAG00000027864.
DR   GeneID; 100034236; -.
DR   KEGG; ecb:100034236; -.
DR   CTD; 3557; -.
DR   VGNC; VGNC:51326; IL1RN.
DR   GeneTree; ENSGT00950000182943; -.
DR   HOGENOM; CLU_095373_2_0_1; -.
DR   InParanoid; O18999; -.
DR   OrthoDB; 1410755at2759; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   Bgee; ENSECAG00000027864; Expressed in blood and 18 other tissues.
DR   ExpressionAtlas; O18999; baseline.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:0045352; F:interleukin-1 type I receptor antagonist activity; IEA:Ensembl.
DR   GO; GO:0045353; F:interleukin-1 type II receptor antagonist activity; IEA:Ensembl.
DR   GO; GO:0005150; F:interleukin-1, type I receptor binding; IEA:Ensembl.
DR   GO; GO:0005151; F:interleukin-1, type II receptor binding; IEA:Ensembl.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0002437; P:inflammatory response to antigenic stimulus; IBA:GO_Central.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR008996; IL1/FGF.
DR   InterPro; IPR039348; IL1RA.
DR   PANTHER; PTHR10078; PTHR10078; 1.
DR   PANTHER; PTHR10078:SF28; PTHR10078:SF28; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..177
FT                   /note="Interleukin-1 receptor antagonist protein"
FT                   /id="PRO_0000015327"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        91..141
FT                   /evidence="ECO:0000250"
FT   CONFLICT        19
FT                   /note="F -> L (in Ref. 2; AAC39257)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        66
FT                   /note="Missing (in Ref. 3; AAD04132)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   177 AA;  20460 MW;  1ABC377F1F1CF80B CRC64;
     MEIRRRSVRH LISLLLFLFY SETACHPLGK RPCKMQAFRI WDVNQKTFYM RNNQLVAGYL
     QESNTKLQEK IDVVPIEPDA LFLGLHGRKL CLACVKSGDE IRFQLEAVNI TDLSKNKEEN
     KRFTFIRSNS GPTTSFESAA CPGWFLCTAQ EADRPVSLTN KPKESFMVTK FYLQEDQ