ID   IL1RA_MACFA             Reviewed;         177 AA.
AC   Q866R8;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12530978; DOI=10.1016/s1074-7613(02)00514-9;
RA   Smith D.E., Hanna R., Friend D., Moore H., Chen H., Farese A.M.,
RA   MacVittie T.J., Virca G.D., Sims J.E.;
RT   "The soluble form of IL-1 receptor accessory protein enhances the ability
RT   of soluble type II IL-1 receptor to inhibit IL-1 action.";
RL   Immunity 18:87-96(2003).
CC   -!- FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of
CC       proinflammatory cytokines such as interleukin-1beta/IL1B and
CC       interleukin-1alpha/IL1A. Protects from immune dysregulation and
CC       uncontrolled systemic inflammation triggered by IL1 for a range of
CC       innate stimulatory agents such as pathogens.
CC       {ECO:0000250|UniProtKB:P25085}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18510}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; AY182232; AAO24703.1; -; mRNA.
DR   RefSeq; NP_001270468.1; NM_001283539.1.
DR   AlphaFoldDB; Q866R8; -.
DR   SMR; Q866R8; -.
DR   STRING; 9541.XP_005575361.1; -.
DR   GeneID; 102126145; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG502S5F0; Eukaryota.
DR   OrthoDB; 1410755at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; IEA:InterPro.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:InterPro.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR008996; IL1/FGF.
DR   InterPro; IPR039348; IL1RA.
DR   PANTHER; PTHR10078; PTHR10078; 1.
DR   PANTHER; PTHR10078:SF28; PTHR10078:SF28; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..177
FT                   /note="Interleukin-1 receptor antagonist protein"
FT                   /id="PRO_0000015329"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        91..141
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   177 AA;  19892 MW;  FB7938A968EF360F CRC64;
     MEICRGLGSH LICLLLFLFH SETVGRPSGR KPSKMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPNVNLEEK IDVVPIEPHA LFLGIHGGKM CLSCVKSGDE TRLQLEAVNI TDLSKNRKQD
     KRFAFVRSDS GPTTSFESAA CPGWFLCTAM EADQPVSLTN MPDKGVMVTK FYFQEDE