ID   IL1RA_PIG               Reviewed;         177 AA.
AC   Q29056;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN; Synonyms=IRAP1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Crossbred; TISSUE=Lung;
RA   Yin J., Murtaugh M.P.;
RT   "Characterization of IRAP in morphine treated pig.";
RL   Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of
CC       proinflammatory cytokines such as interleukin-1beta/IL1B and
CC       interleukin-1alpha/IL1A. Protects from immune dysregulation and
CC       uncontrolled systemic inflammation triggered by IL1 for a range of
CC       innate stimulatory agents such as pathogens.
CC       {ECO:0000250|UniProtKB:P25085}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18510}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; L38849; AAA99424.1; -; mRNA.
DR   RefSeq; NP_999427.1; NM_214262.1.
DR   AlphaFoldDB; Q29056; -.
DR   SMR; Q29056; -.
DR   PeptideAtlas; Q29056; -.
DR   GeneID; 397499; -.
DR   CTD; 3557; -.
DR   InParanoid; Q29056; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; IBA:GO_Central.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0002437; P:inflammatory response to antigenic stimulus; IBA:GO_Central.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IBA:GO_Central.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR008996; IL1/FGF.
DR   InterPro; IPR039348; IL1RA.
DR   PANTHER; PTHR10078; PTHR10078; 1.
DR   PANTHER; PTHR10078:SF28; PTHR10078:SF28; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..177
FT                   /note="Interleukin-1 receptor antagonist protein"
FT                   /id="PRO_0000015331"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        91..141
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   177 AA;  20093 MW;  2114DC6119A9D5F9 CRC64;
     MEVSRYLCSY LISFLLFLFH SETACHPLGK RPCRMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPNTKLEEK IDVVPVEPHF VFLGIHGGKL CLSCVKSGDE MKLQLDAVNI TDLRKNSEQD
     KRFTFIRSDS GPTTSFESAA CPGWFLCTAL EADQPVGLTN TPKAAVKVTK FYFQQDQ