ID   IL1RA_RABIT             Reviewed;         177 AA.
AC   P26890;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Interleukin-1 receptor antagonist protein;
DE            Short=IL-1RN;
DE            Short=IL-1ra;
DE            Short=IRAP;
DE   AltName: Full=IL1 inhibitor;
DE   Flags: Precursor;
GN   Name=IL1RN; Synonyms=IL1RA;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7509813; DOI=10.1016/s0021-9258(17)37468-9;
RA   Cominelli F., Bortolami M., Pizarro T.T., Monsacchi L., Ferretti M.,
RA   Brewer M.T., Eisenberg S.P., Ng R.K.;
RT   "Rabbit interleukin-1 receptor antagonist. Cloning, expression, functional
RT   characterization, and regulation during intestinal inflammation.";
RL   J. Biol. Chem. 269:6962-6971(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hamada H., Mulligan R.C.;
RL   Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1427977;
RA   Goto F., Goto K., Miyata T., Ohkawara S., Takao T., Mori S., Furukawa S.,
RA   Maeda T., Iwanaga S., Shimonishi Y., Yoshinaga M.;
RT   "Interleukin-1 receptor antagonist in inflammatory exudate cells of
RT   rabbits. Production, purification and determination of primary structure.";
RL   Immunology 77:235-244(1992).
CC   -!- FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of
CC       proinflammatory cytokines such as interleukin-1beta/IL1B and
CC       interleukin-1alpha/IL1A. Protects from immune dysregulation and
CC       uncontrolled systemic inflammation triggered by IL1 for a range of
CC       innate stimulatory agents such as pathogens.
CC       {ECO:0000250|UniProtKB:P25085}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18510}.
CC   -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR   EMBL; S68977; AAB30093.1; -; mRNA.
DR   EMBL; M57526; AAA31374.1; -; mRNA.
DR   EMBL; D21832; BAA04860.1; -; mRNA.
DR   PIR; A54377; A54377.
DR   RefSeq; NP_001076239.1; NM_001082770.1.
DR   AlphaFoldDB; P26890; -.
DR   SMR; P26890; -.
DR   STRING; 9986.ENSOCUP00000021003; -.
DR   GeneID; 100009558; -.
DR   KEGG; ocu:100009558; -.
DR   CTD; 3557; -.
DR   eggNOG; ENOG502S5F0; Eukaryota.
DR   InParanoid; P26890; -.
DR   OrthoDB; 1410755at2759; -.
DR   TreeFam; TF300203; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0005152; F:interleukin-1 receptor antagonist activity; IEA:InterPro.
DR   GO; GO:0005149; F:interleukin-1 receptor binding; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR   GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; IEA:InterPro.
DR   InterPro; IPR020877; IL-1_CS.
DR   InterPro; IPR000975; IL-1_fam.
DR   InterPro; IPR003297; IL-1RA/IL-36.
DR   InterPro; IPR008996; IL1/FGF.
DR   InterPro; IPR039348; IL1RA.
DR   PANTHER; PTHR10078; PTHR10078; 1.
DR   PANTHER; PTHR10078:SF28; PTHR10078:SF28; 1.
DR   Pfam; PF00340; IL1; 1.
DR   PRINTS; PR00264; INTERLEUKIN1.
DR   PRINTS; PR01360; INTRLEUKIN1X.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00253; INTERLEUKIN_1; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000250"
FT   CHAIN           26..177
FT                   /note="Interleukin-1 receptor antagonist protein"
FT                   /id="PRO_0000015332"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        91..141
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   177 AA;  20214 MW;  F5BC087F097FFEAF CRC64;
     MRPSRSTRRH LISLLLFLFH SETACRPSGK RPCRMQAFRI WDVNQKTFYL RNNQLVAGYL
     QGPNAKLEER IDVVPLEPQL LFLGIQRGKL CLSCVKSGDK MKLHLEAVNI TDLGKNKEQD
     KRFTFIRSNS GPTTTFESAS CPGWFLCTAL EADQPVSLTN TPDDSIVVTK FYFQEDQ