IL1RA_RAT
ID IL1RA_RAT Reviewed; 178 AA.
AC P25086;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Interleukin-1 receptor antagonist protein;
DE Short=IL-1RN;
DE Short=IL-1ra;
DE Short=IRAP;
DE AltName: Full=IL1 inhibitor;
DE Flags: Precursor;
GN Name=Il1rn; Synonyms=Il-1ra;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1828896; DOI=10.1073/pnas.88.12.5232;
RA Eisenberg S.P., Brewer M.T., Verderber E., Heimdal P., Brandhuber B.J.,
RA Thompson R.C.;
RT "Interleukin 1 receptor antagonist is a member of the interleukin 1 gene
RT family: evolution of a cytokine control mechanism.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:5232-5236(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of
CC proinflammatory cytokines such as interleukin-1beta/IL1B and
CC interleukin-1alpha/IL1A. Protects from immune dysregulation and
CC uncontrolled systemic inflammation triggered by IL1 for a range of
CC innate stimulatory agents such as pathogens.
CC {ECO:0000250|UniProtKB:P25085}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18510}.
CC -!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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DR EMBL; M63101; AAA41434.1; -; Genomic_DNA.
DR EMBL; BC070930; AAH70930.1; -; mRNA.
DR PIR; C40956; C40956.
DR RefSeq; NP_071530.1; NM_022194.2.
DR AlphaFoldDB; P25086; -.
DR SMR; P25086; -.
DR STRING; 10116.ENSRNOP00000007949; -.
DR GlyGen; P25086; 1 site.
DR PaxDb; P25086; -.
DR PRIDE; P25086; -.
DR GeneID; 60582; -.
DR KEGG; rno:60582; -.
DR UCSC; RGD:621159; rat.
DR CTD; 3557; -.
DR RGD; 621159; Il1rn.
DR eggNOG; ENOG502S5F0; Eukaryota.
DR HOGENOM; CLU_095373_2_0_1; -.
DR InParanoid; P25086; -.
DR OrthoDB; 1410755at2759; -.
DR PhylomeDB; P25086; -.
DR TreeFam; TF300203; -.
DR Reactome; R-RNO-9020702; Interleukin-1 signaling.
DR PRO; PR:P25086; -.
DR Proteomes; UP000002494; Unplaced.
DR Genevisible; P25086; RN.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0031982; C:vesicle; ISO:RGD.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0005152; F:interleukin-1 receptor antagonist activity; ISO:RGD.
DR GO; GO:0005149; F:interleukin-1 receptor binding; IDA:RGD.
DR GO; GO:0045352; F:interleukin-1 type I receptor antagonist activity; ISO:RGD.
DR GO; GO:0045353; F:interleukin-1 type II receptor antagonist activity; ISO:RGD.
DR GO; GO:0005150; F:interleukin-1, type I receptor binding; ISO:RGD.
DR GO; GO:0005151; F:interleukin-1, type II receptor binding; ISO:RGD.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEP:RGD.
DR GO; GO:0071874; P:cellular response to norepinephrine stimulus; IEP:RGD.
DR GO; GO:0002439; P:chronic inflammatory response to antigenic stimulus; IEP:RGD.
DR GO; GO:0007565; P:female pregnancy; IEP:RGD.
DR GO; GO:0001660; P:fever generation; IMP:RGD.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IBA:GO_Central.
DR GO; GO:0030073; P:insulin secretion; ISO:RGD.
DR GO; GO:0006629; P:lipid metabolic process; ISO:RGD.
DR GO; GO:0007613; P:memory; IMP:RGD.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
DR GO; GO:0030336; P:negative regulation of cell migration; IDA:RGD.
DR GO; GO:0014050; P:negative regulation of glutamate secretion; IMP:RGD.
DR GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; ISO:RGD.
DR GO; GO:2000660; P:negative regulation of interleukin-1-mediated signaling pathway; ISO:RGD.
DR GO; GO:0045837; P:negative regulation of membrane potential; IDA:RGD.
DR GO; GO:0009968; P:negative regulation of signal transduction; TAS:RGD.
DR GO; GO:0043507; P:positive regulation of JUN kinase activity; IMP:RGD.
DR GO; GO:0014823; P:response to activity; IEP:RGD.
DR GO; GO:0051384; P:response to glucocorticoid; ISO:RGD.
DR GO; GO:0070555; P:response to interleukin-1; IEP:RGD.
DR GO; GO:0070670; P:response to interleukin-4; IEP:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0010243; P:response to organonitrogen compound; IEP:RGD.
DR GO; GO:0042594; P:response to starvation; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0019233; P:sensory perception of pain; IMP:RGD.
DR InterPro; IPR020877; IL-1_CS.
DR InterPro; IPR000975; IL-1_fam.
DR InterPro; IPR003297; IL-1RA/IL-36.
DR InterPro; IPR008996; IL1/FGF.
DR InterPro; IPR039348; IL1RA.
DR PANTHER; PTHR10078; PTHR10078; 1.
DR PANTHER; PTHR10078:SF28; PTHR10078:SF28; 1.
DR Pfam; PF00340; IL1; 1.
DR PRINTS; PR00264; INTERLEUKIN1.
DR PRINTS; PR01360; INTRLEUKIN1X.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00253; INTERLEUKIN_1; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..178
FT /note="Interleukin-1 receptor antagonist protein"
FT /id="PRO_0000015333"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 92..142
FT /evidence="ECO:0000250"
SQ SEQUENCE 178 AA; 20282 MW; F3A5754FB6C51B03 CRC64;
MEICRGPYSH LISLLLILLF RSESAGHPAG KRPCKMQAFR IWDTNQKTFY LRNNQLIAGY
LQGPNTKLEE KIDMVPIDFR NVFLGIHGGK LCLSCVKSGD DTKLQLEEVN ITDLNKNKEE
DKRFTFIRSE TGPTTSFESL ACPGWFLCTT LEADHPVSLT NTPKEPCTVT KFYFQEDQ
