ID   IL20_MOUSE              Reviewed;         176 AA.
AC   Q9JKV9;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Interleukin-20;
DE            Short=IL-20;
DE   AltName: Full=Cytokine Zcyto10;
DE   Flags: Precursor;
GN   Name=Il20; Synonyms=Zcyto10;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=11163236; DOI=10.1016/s0092-8674(01)00187-8;
RA   Blumberg H., Conklin D., Xu W.F., Grossmann A., Brender T., Carollo S.,
RA   Eagan M., Foster D., Haldeman B.A., Hammond A., Haugen H., Jelinek L.,
RA   Kelly J.D., Madden K., Maurer M.F., Parrish-Novak J., Prunkard D.,
RA   Sexson S., Sprecher C., Waggie K., West J., Whitmore T.E., Yao L.,
RA   Kuechle M.K., Dale B.A., Chandrasekher Y.A.;
RT   "Interleukin 20: discovery, receptor identification, and role in epidermal
RT   function.";
RL   Cell 104:9-19(2001).
CC   -!- FUNCTION: Cytokine that may be involved in epidermal function and
CC       psoriasis. Acts through STAT3.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
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DR   EMBL; AF224267; AAF36680.1; -; mRNA.
DR   CCDS; CCDS15263.1; -.
DR   RefSeq; NP_001298020.1; NM_001311091.1.
DR   RefSeq; NP_067355.1; NM_021380.2.
DR   AlphaFoldDB; Q9JKV9; -.
DR   SMR; Q9JKV9; -.
DR   STRING; 10090.ENSMUSP00000027673; -.
DR   PhosphoSitePlus; Q9JKV9; -.
DR   PaxDb; Q9JKV9; -.
DR   PRIDE; Q9JKV9; -.
DR   Antibodypedia; 34589; 476 antibodies from 31 providers.
DR   DNASU; 58181; -.
DR   Ensembl; ENSMUST00000027673; ENSMUSP00000027673; ENSMUSG00000026416.
DR   GeneID; 58181; -.
DR   KEGG; mmu:58181; -.
DR   UCSC; uc007cmr.1; mouse.
DR   CTD; 50604; -.
DR   MGI; MGI:1890473; Il20.
DR   VEuPathDB; HostDB:ENSMUSG00000026416; -.
DR   eggNOG; ENOG502S5RZ; Eukaryota.
DR   GeneTree; ENSGT00950000183124; -.
DR   HOGENOM; CLU_098690_0_0_1; -.
DR   InParanoid; Q9JKV9; -.
DR   OMA; TVHTHEL; -.
DR   OrthoDB; 1267998at2759; -.
DR   PhylomeDB; Q9JKV9; -.
DR   TreeFam; TF333253; -.
DR   BioGRID-ORCS; 58181; 1 hit in 72 CRISPR screens.
DR   PRO; PR:Q9JKV9; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q9JKV9; protein.
DR   Bgee; ENSMUSG00000026416; Expressed in animal zygote and 15 other tissues.
DR   ExpressionAtlas; Q9JKV9; baseline and differential.
DR   Genevisible; Q9JKV9; MM.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IDA:MGI.
DR   GO; GO:0045517; F:interleukin-20 receptor binding; IDA:UniProtKB.
DR   GO; GO:0045518; F:interleukin-22 receptor binding; IPI:MGI.
DR   GO; GO:0030097; P:hemopoiesis; NAS:UniProtKB.
DR   GO; GO:0030316; P:osteoclast differentiation; IMP:MGI.
DR   GO; GO:0045672; P:positive regulation of osteoclast differentiation; IMP:MGI.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
DR   InterPro; IPR020423; IL-10_CS.
DR   InterPro; IPR020442; IL-20.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01935; INTRLEUKIN20.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..176
FT                   /note="Interleukin-20"
FT                   /id="PRO_0000015382"
FT   DISULFID        33..126
FT                   /evidence="ECO:0000255"
FT   DISULFID        80..132
FT                   /evidence="ECO:0000255"
FT   DISULFID        81..134
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   176 AA;  20098 MW;  08577AF656574771 CRC64;
     MKGFGLAFGL FSAVGFLLWT PLTGLKTLHL GSCVITANLQ AIQKEFSEIR DSVQAEDTNI
     DIRILRTTES LKDIKSLDRC CFLRHLVRFY LDRVFKVYQT PDHHTLRKIS SLANSFLIIK
     KDLSVCHSHM ACHCGEEAME KYNQILSHFI ELELQAAVVK ALGELGILLR WMEEML