IL21R_MOUSE
ID IL21R_MOUSE Reviewed; 529 AA.
AC Q9JHX3; Q9ESM1;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Interleukin-21 receptor;
DE Short=IL-21 receptor;
DE Short=IL-21R;
DE AltName: Full=Lymphocyte receptor beta;
DE Short=LR-beta;
DE AltName: Full=Novel cytokine receptor 8;
DE Short=NR8;
DE AltName: Full=Novel interleukin receptor;
DE AltName: CD_antigen=CD360;
DE Flags: Precursor;
GN Name=Il21r; Synonyms=Nilr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=11081504; DOI=10.1038/35040504;
RA Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C.,
RA Gross J.A., Johnston J., Madden K., Xu W., West J., Schrader S.,
RA Burkhead S., Heipel M., Brandt C., Kuijper J.L., Kramer J., Conklin D.,
RA Presnell S.R., Berry J., Shiota F., Bort S., Hambly K., Mudri S., Clegg C.,
RA Moore M., Grant F.J., Lofton-Day C., Gilbert T., Raymond F., Ching A.,
RA Yao L., Smith D., Webster P., Whitmore T., Maurer M., Kaushansky K.,
RA Holly R.D., Foster D.;
RT "Interleukin 21 and its receptor are involved in NK cell expansion and
RT regulation of lymphocyte function.";
RL Nature 408:57-63(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen, and Thymus;
RX PubMed=11016959; DOI=10.1073/pnas.200360997;
RA Ozaki K., Kikly K., Michalovich D., Young P.R., Leonard W.J.;
RT "Cloning of a type I cytokine receptor most related to the IL-2 receptor
RT beta chain.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:11439-11444(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Donaldson D.D., Whitters M.J., Fitz L., Unger M., Finnerty H.,
RA Dagdigian C., Lowe L., Wood C.R., Young D.A., Collins M.;
RT "Chromosome 16p12 encodes a biologically active IL-2Rb related receptor
RT with lymphoid restricted expression.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Nomura H., Yaguchi N., Maeda M., Hasegawa M.;
RT "A novel cytokine receptor NR8 is closely mapped to IL-4R: polymorphism in
RT Balb/c mouse.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=A/J, B10.S/DvTe, C57BL/6J, NOD/LtJ, and SJL/J; TISSUE=Spleen;
RA Gao J., Teuscher C.;
RT "Mus musculus interleukin 21 receptor gene Il21r mRNA.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This is a receptor for interleukin-21.
CC -!- SUBUNIT: Heterodimer with the common gamma subunit. Associates with
CC JAK1.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- TISSUE SPECIFICITY: Selectively expressed in lymphoid tissues. Most
CC highly expressed in thymus and spleen.
CC -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC folding and thereby efficient intracellular transport and cell-surface
CC receptor binding.
CC -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC activation.
CC -!- PTM: C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain
CC makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two
CC fibronectin domains transforming the V-shaped receptor into an A-frame.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 4
CC subfamily. {ECO:0000305}.
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DR EMBL; AF254068; AAG29347.1; -; mRNA.
DR EMBL; AF269134; AAG23420.1; -; mRNA.
DR EMBL; AF279436; AAF86350.1; -; mRNA.
DR EMBL; AB049137; BAB13736.1; -; mRNA.
DR EMBL; AF477982; AAL82632.1; -; mRNA.
DR EMBL; AF477983; AAL82633.1; -; mRNA.
DR EMBL; AF477984; AAL82634.1; -; mRNA.
DR EMBL; AF477985; AAL82635.1; -; mRNA.
DR EMBL; AF477986; AAL82636.1; -; mRNA.
DR CCDS; CCDS21823.1; -.
DR RefSeq; NP_068687.1; NM_021887.2.
DR AlphaFoldDB; Q9JHX3; -.
DR SMR; Q9JHX3; -.
DR STRING; 10090.ENSMUSP00000033000; -.
DR GlyGen; Q9JHX3; 6 sites.
DR iPTMnet; Q9JHX3; -.
DR PhosphoSitePlus; Q9JHX3; -.
DR PaxDb; Q9JHX3; -.
DR PRIDE; Q9JHX3; -.
DR ProteomicsDB; 267040; -.
DR ABCD; Q9JHX3; 35 sequenced antibodies.
DR Antibodypedia; 12828; 457 antibodies from 41 providers.
DR DNASU; 60504; -.
DR Ensembl; ENSMUST00000033000; ENSMUSP00000033000; ENSMUSG00000030745.
DR GeneID; 60504; -.
DR KEGG; mmu:60504; -.
DR UCSC; uc012ftn.1; mouse.
DR CTD; 50615; -.
DR MGI; MGI:1890475; Il21r.
DR VEuPathDB; HostDB:ENSMUSG00000030745; -.
DR eggNOG; ENOG502S0QM; Eukaryota.
DR GeneTree; ENSGT00510000048783; -.
DR HOGENOM; CLU_039739_0_0_1; -.
DR InParanoid; Q9JHX3; -.
DR OMA; RFFQPLY; -.
DR OrthoDB; 774083at2759; -.
DR PhylomeDB; Q9JHX3; -.
DR TreeFam; TF337874; -.
DR Reactome; R-MMU-9020958; Interleukin-21 signaling.
DR BioGRID-ORCS; 60504; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Il21r; mouse.
DR PRO; PR:Q9JHX3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9JHX3; protein.
DR Bgee; ENSMUSG00000030745; Expressed in thymus and 45 other tissues.
DR ExpressionAtlas; Q9JHX3; baseline and differential.
DR Genevisible; Q9JHX3; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IDA:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0016064; P:immunoglobulin mediated immune response; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..529
FT /note="Interleukin-21 receptor"
FT /id="PRO_0000010882"
FT TOPO_DOM 20..237
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..529
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 21..118
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 119..228
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 458..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 214..218
FT /note="WSXWS motif"
FT MOTIF 266..274
FT /note="Box 1 motif"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 214
FT /note="C-linked (Man) tryptophan"
FT /evidence="ECO:0000250|UniProtKB:Q9HBE5"
FT DISULFID 20..109
FT /evidence="ECO:0000250"
FT DISULFID 25..35
FT /evidence="ECO:0000250"
FT DISULFID 65..81
FT /evidence="ECO:0000250"
FT VARIANT 69
FT /note="R -> K (in strain: BALB/c and SJL/J)"
FT VARIANT 200
FT /note="V -> M (in strain: BALB/c and SJL/J)"
SQ SEQUENCE 529 AA; 58355 MW; 8B41816B0D426581 CRC64;
MPRGPVAALL LLILHGAWSC LDLTCYTDYL WTITCVLETR SPNPSILSLT WQDEYEELQD
QETFCSLHRS GHNTTHIWYT CHMRLSQFLS DEVFIVNVTD QSGNNSQECG SFVLAESIKP
APPLNVTVAF SGRYDISWDS AYDEPSNYVL RGKLQYELQY RNLRDPYAVR PVTKLISVDS
RNVSLLPEEF HKDSSYQLQV RAAPQPGTSF RGTWSEWSDP VIFQTQAGEP EAGWDPHMLL
LLAVLIIVLV FMGLKIHLPW RLWKKIWAPV PTPESFFQPL YREHSGNFKK WVNTPFTASS
IELVPQSSTT TSALHLSLYP AKEKKFPGLP GLEEQLECDG MSEPGHWCII PLAAGQAVSA
YSEERDRPYG LVSIDTVTVG DAEGLCVWPC SCEDDGYPAM NLDAGRESGP NSEDLLLVTD
PAFLSCGCVS GSGLRLGGSP GSLLDRLRLS FAKEGDWTAD PTWRTGSPGG GSESEAGSPP
GLDMDTFDSG FAGSDCGSPV ETDEGPPRSY LRQWVVRTPP PVDSGAQSS
