IL21_CANLF
ID IL21_CANLF Reviewed; 146 AA.
AC Q6L7I9;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Interleukin-21;
DE Short=IL-21;
DE Flags: Precursor;
GN Name=IL21;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RA Miyake M., Saze K., Haga Y., Yamamoto Y., Iwabuchi S.;
RT "Molecular cloning of canine interleukin-21 cDNA.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytokine with immunoregulatory activity. May promote the
CC transition between innate and adaptive immunity. Induces the production
CC of IgG(1) and IgG(3) in B-cells. Implicated in the generation and
CC maintenance of T follicular helper (Tfh) cells and the formation of
CC germinal-centers. Together with IL6, control the early generation of
CC Tfh cells and are critical for an effective antibody response to acute
CC viral infection (By similarity). May play a role in proliferation and
CC maturation of natural killer (NK) cells in synergy with IL15. May
CC regulate proliferation of mature B- and T-cells in response to
CC activating stimuli. In synergy with IL15 and IL18 stimulates interferon
CC gamma production in T-cells and NK cells (By similarity). During T-cell
CC mediated immune response may inhibit dendritic cells (DC) activation
CC and maturation (By similarity). {ECO:0000250|UniProtKB:Q9ES17,
CC ECO:0000250|UniProtKB:Q9HBE4}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9HBE4}.
CC -!- SIMILARITY: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
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DR EMBL; AB127975; BAD22569.1; -; mRNA.
DR RefSeq; NP_001003347.1; NM_001003347.1.
DR AlphaFoldDB; Q6L7I9; -.
DR SMR; Q6L7I9; -.
DR STRING; 9612.ENSCAFP00000005939; -.
DR PaxDb; Q6L7I9; -.
DR Ensembl; ENSCAFT00030011201; ENSCAFP00030009794; ENSCAFG00030006099.
DR Ensembl; ENSCAFT00040023468; ENSCAFP00040020365; ENSCAFG00040012716.
DR Ensembl; ENSCAFT00845035435; ENSCAFP00845027737; ENSCAFG00845020106.
DR GeneID; 442935; -.
DR KEGG; cfa:442935; -.
DR CTD; 59067; -.
DR VEuPathDB; HostDB:ENSCAFG00845020106; -.
DR eggNOG; ENOG502SES1; Eukaryota.
DR GeneTree; ENSGT00390000010494; -.
DR HOGENOM; CLU_127182_1_0_1; -.
DR InParanoid; Q6L7I9; -.
DR OMA; MIHQHLR; -.
DR OrthoDB; 1439856at2759; -.
DR TreeFam; TF336380; -.
DR Reactome; R-CFA-9020958; Interleukin-21 signaling.
DR Proteomes; UP000002254; Chromosome 19.
DR Bgee; ENSCAFG00000004004; Expressed in lymph node and 4 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005134; F:interleukin-2 receptor binding; IEA:Ensembl.
DR GO; GO:0048469; P:cell maturation; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; ISS:UniProtKB.
DR GO; GO:0002314; P:germinal center B cell differentiation; ISS:UniProtKB.
DR GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; ISS:UniProtKB.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IBA:GO_Central.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:0061470; P:T follicular helper cell differentiation; ISS:UniProtKB.
DR GO; GO:0007260; P:tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR Gene3D; 1.20.1250.70; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR003443; IL-15/IL-21_fam.
DR PANTHER; PTHR14356; PTHR14356; 1.
DR Pfam; PF02372; IL15; 1.
DR SUPFAM; SSF47266; SSF47266; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000250|UniProtKB:Q76LU5"
FT CHAIN 18..146
FT /note="Interleukin-21"
FT /id="PRO_0000015504"
FT REGION 100..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 64..115
FT /evidence="ECO:0000250|UniProtKB:Q9HBE4"
FT DISULFID 71..118
FT /evidence="ECO:0000250|UniProtKB:Q9HBE4"
SQ SEQUENCE 146 AA; 16776 MW; FFE8DF836AF219AA CRC64;
MEKIVICLMV IFLGTVAHKS SFQEQDLLLI RMRQLIDIVD QLKNYVNDLD PESLPAPEDV
KRHCERSAFS CFQKVQLKAA NTGGNEQIIN VLTKQLKRKL PPTNAGRRQK HRPACPSCDS
YEKAPPKEFL ERLKSLIQKM IHQHLS