ID   IL21_PERMA              Reviewed;         123 AA.
AC   Q80XG2;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Interleukin-21;
DE            Short=IL-21;
DE   Flags: Precursor; Fragment;
GN   Name=Il21;
OS   Peromyscus maniculatus (North American deer mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Neotominae; Peromyscus.
OX   NCBI_TaxID=10042;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Schountz T., Buniger A., Davenport B., Hegg T.;
RT   "Cloning of deer mouse IL-2, IL-12 p35, IL-21, GM-CSF, CCL3 and CCL4
RT   cDNAs.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytokine with immunoregulatory activity. May promote the
CC       transition between innate and adaptive immunity. Induces the production
CC       of IgG(1) and IgG(3) in B-cells. Implicated in the generation and
CC       maintenance of T follicular helper (Tfh) cells and the formation of
CC       germinal-centers. Together with IL6, control the early generation of
CC       Tfh cells and are critical for an effective antibody response to acute
CC       viral infection (By similarity). May play a role in proliferation and
CC       maturation of natural killer (NK) cells in synergy with IL15. May
CC       regulate proliferation of mature B- and T-cells in response to
CC       activating stimuli. In synergy with IL15 and IL18 stimulates interferon
CC       gamma production in T-cells and NK cells (By similarity). During T-cell
CC       mediated immune response may inhibit dendritic cells (DC) activation
CC       and maturation (By similarity). {ECO:0000250|UniProtKB:Q9ES17,
CC       ECO:0000250|UniProtKB:Q9HBE4}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9HBE4}.
CC   -!- SIMILARITY: Belongs to the IL-15/IL-21 family. {ECO:0000305}.
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DR   EMBL; AY247761; AAP04420.1; -; mRNA.
DR   AlphaFoldDB; Q80XG2; -.
DR   SMR; Q80XG2; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
DR   GO; GO:0098586; P:cellular response to virus; ISS:UniProtKB.
DR   GO; GO:0002314; P:germinal center B cell differentiation; ISS:UniProtKB.
DR   GO; GO:0002639; P:positive regulation of immunoglobulin production; ISS:UniProtKB.
DR   GO; GO:0061470; P:T follicular helper cell differentiation; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.70; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003443; IL-15/IL-21_fam.
DR   PANTHER; PTHR14356; PTHR14356; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Secreted; Signal.
FT   SIGNAL          <1..10
FT                   /evidence="ECO:0000255"
FT   CHAIN           11..123
FT                   /note="Interleukin-21"
FT                   /id="PRO_0000015507"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        56..107
FT                   /evidence="ECO:0000250|UniProtKB:Q9HBE4"
FT   DISULFID        63..110
FT                   /evidence="ECO:0000250|UniProtKB:Q9HBE4"
FT   NON_TER         1
FT   NON_TER         123
SQ   SEQUENCE   123 AA;  13945 MW;  8656C8EA95447E34 CRC64;
     VVIFLGTVAH KTSPQRPDRL LIRLRHLVDN VEQLKIYVND LDPELLPAPQ DVKEHCAHSA
     FACFQKAKLK PANTGSNKTI ISDLVTQLRR RLPATKAEKK QQSLVKCPSC DSYEKKTPKE
     FLE