ID   IL22B_MOUSE             Reviewed;         179 AA.
AC   Q9JJY8; E9QAL9;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Interleukin-22b;
DE            Short=IL-22b;
DE   AltName: Full=IL-10-related T-cell-derived-inducible factor beta;
DE            Short=IL-TIF beta;
DE            Short=IL-TIFb;
DE   Flags: Precursor;
GN   Name=Il22b {ECO:0000312|MGI:MGI:2151139};
GN   Synonyms=Iltifb {ECO:0000303|PubMed:11197690};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=129;
RX   PubMed=10657629; DOI=10.4049/jimmunol.164.4.1814;
RA   Dumoutier L., Louahed J., Renauld J.-C.;
RT   "Cloning and characterization of IL-10-related T cell-derived inducible
RT   factor (IL-TIF), a novel cytokine structurally related to IL-10 and
RT   inducible by IL-9.";
RL   J. Immunol. 164:1814-1819(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129;
RX   PubMed=11197690; DOI=10.1038/sj.gene.6363716;
RA   Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C.;
RT   "IL-TIF/IL-22: genomic organization and mapping of the human and mouse
RT   genes.";
RL   Genes Immun. 1:488-494(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Cytokine that contributes to the inflammatory response in
CC       vivo.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ249492; CAB75547.1; -; mRNA.
DR   EMBL; AJ294728; CAC19436.1; -; Genomic_DNA.
DR   EMBL; AC158600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS48700.1; -.
DR   RefSeq; NP_473420.2; NM_054079.2.
DR   AlphaFoldDB; Q9JJY8; -.
DR   SMR; Q9JJY8; -.
DR   STRING; 10090.ENSMUSP00000128415; -.
DR   GlyGen; Q9JJY8; 3 sites.
DR   PaxDb; Q9JJY8; -.
DR   PRIDE; Q9JJY8; -.
DR   DNASU; 116849; -.
DR   Ensembl; ENSMUST00000163808; ENSMUSP00000128415; ENSMUSG00000090461.
DR   GeneID; 116849; -.
DR   KEGG; mmu:116849; -.
DR   UCSC; uc007hdx.1; mouse.
DR   CTD; 116849; -.
DR   MGI; MGI:2151139; Il22b.
DR   VEuPathDB; HostDB:ENSMUSG00000090461; -.
DR   eggNOG; ENOG502S5PC; Eukaryota.
DR   GeneTree; ENSGT00510000048550; -.
DR   HOGENOM; CLU_127397_0_0_1; -.
DR   InParanoid; Q9JJY8; -.
DR   OMA; INTRCKL; -.
DR   OrthoDB; 1406348at2759; -.
DR   PhylomeDB; Q9JJY8; -.
DR   TreeFam; TF333253; -.
DR   BioGRID-ORCS; 116849; 3 hits in 69 CRISPR screens.
DR   PRO; PR:Q9JJY8; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q9JJY8; protein.
DR   Bgee; ENSMUSG00000090461; Expressed in morula and 12 other tissues.
DR   Genevisible; Q9JJY8; MM.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR020423; IL-10_CS.
DR   InterPro; IPR020453; IL-22.
DR   Pfam; PF14565; IL22; 1.
DR   PIRSF; PIRSF037726; Interleukin-22; 1.
DR   PRINTS; PR01936; INTRLEUKIN22.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..179
FT                   /note="Interleukin-22b"
FT                   /id="PRO_0000015385"
FT   CARBOHYD        54
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        40..132
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..178
FT                   /evidence="ECO:0000250"
FT   CONFLICT        63
FT                   /note="V -> A (in Ref. 1; CAB75547 and 2; CAC19436)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        73
FT                   /note="W -> R (in Ref. 1; CAB75547 and 2; CAC19436)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        103
FT                   /note="V -> I (in Ref. 1; CAB75547 and 2; CAC19436)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        112
FT                   /note="Q -> R (in Ref. 1; CAB75547 and 2; CAC19436)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   179 AA;  20179 MW;  FAF43A9701812482 CRC64;
     MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPINTRC KLEVSNFQQP YIVNRTFMLA
     KEVSLADNNT DVWLIGEKLF RGVSAKDQCY LMKQVLNFTL EDVLLPQSDR FQPYMQEVVP
     FLTKLSNQLS SCHISGDDQN IQKNVRRLKE TVKKLGESGE IKAIGELDLL FMSLRNACV