IL22_MOUSE
ID IL22_MOUSE Reviewed; 179 AA.
AC Q9JJY9; Q14BB3;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Interleukin-22;
DE Short=IL-22;
DE AltName: Full=IL-10-related T-cell-derived-inducible factor;
DE Short=IL-TIF;
DE AltName: Full=IL-TIF alpha;
DE AltName: Full=Interleukin-22a;
DE Short=IL-22a;
DE Flags: Precursor;
GN Name=Il22; Synonyms=Il22a, Iltif, Iltifa;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AKR/J;
RX PubMed=10657629; DOI=10.4049/jimmunol.164.4.1814;
RA Dumoutier L., Louahed J., Renauld J.-C.;
RT "Cloning and characterization of IL-10-related T cell-derived inducible
RT factor (IL-TIF), a novel cytokine structurally related to IL-10 and
RT inducible by IL-9.";
RL J. Immunol. 164:1814-1819(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129;
RX PubMed=11197690; DOI=10.1038/sj.gene.6363716;
RA Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C.;
RT "IL-TIF/IL-22: genomic organization and mapping of the human and mouse
RT genes.";
RL Genes Immun. 1:488-494(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cytokine that contributes to the inflammatory response in
CC vivo.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
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DR EMBL; AJ249491; CAB75546.1; -; mRNA.
DR EMBL; AJ294727; CAC19435.1; -; Genomic_DNA.
DR EMBL; BC116235; AAI16236.1; -; mRNA.
DR CCDS; CCDS36070.1; -.
DR RefSeq; NP_058667.1; NM_016971.2.
DR RefSeq; XP_006513928.1; XM_006513865.3.
DR PDB; 6WEO; X-ray; 2.60 A; 2/5/8/D/G/J/L/N/Q/T/W/Z=34-179.
DR PDBsum; 6WEO; -.
DR AlphaFoldDB; Q9JJY9; -.
DR SMR; Q9JJY9; -.
DR MINT; Q9JJY9; -.
DR STRING; 10090.ENSMUSP00000094449; -.
DR GlyGen; Q9JJY9; 3 sites.
DR PhosphoSitePlus; Q9JJY9; -.
DR PaxDb; Q9JJY9; -.
DR PRIDE; Q9JJY9; -.
DR ABCD; Q9JJY9; 4 sequenced antibodies.
DR DNASU; 50929; -.
DR Ensembl; ENSMUST00000096691; ENSMUSP00000094449; ENSMUSG00000074695.
DR GeneID; 50929; -.
DR KEGG; mmu:50929; -.
DR UCSC; uc007hdv.2; mouse.
DR CTD; 50616; -.
DR MGI; MGI:1355307; Il22.
DR VEuPathDB; HostDB:ENSMUSG00000074695; -.
DR eggNOG; ENOG502S5PC; Eukaryota.
DR GeneTree; ENSGT00510000048550; -.
DR HOGENOM; CLU_127397_0_0_1; -.
DR InParanoid; Q9JJY9; -.
DR OMA; YMQEVVS; -.
DR OrthoDB; 1406348at2759; -.
DR PhylomeDB; Q9JJY9; -.
DR TreeFam; TF333253; -.
DR BioGRID-ORCS; 50929; 1 hit in 51 CRISPR screens.
DR PRO; PR:Q9JJY9; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9JJY9; protein.
DR Bgee; ENSMUSG00000074695; Expressed in morula and 10 other tissues.
DR Genevisible; Q9JJY9; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0072593; P:reactive oxygen species metabolic process; IDA:MGI.
DR GO; GO:0042509; P:regulation of tyrosine phosphorylation of STAT protein; IDA:MGI.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR020423; IL-10_CS.
DR InterPro; IPR020453; IL-22.
DR Pfam; PF14565; IL22; 1.
DR PIRSF; PIRSF037726; Interleukin-22; 1.
DR PRINTS; PR01936; INTRLEUKIN22.
DR SUPFAM; SSF47266; SSF47266; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytokine; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..179
FT /note="Interleukin-22"
FT /id="PRO_0000015384"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 40..132
FT /evidence="ECO:0000250"
FT DISULFID 89..178
FT /evidence="ECO:0000250"
FT HELIX 44..47
FT /evidence="ECO:0007829|PDB:6WEO"
FT HELIX 50..64
FT /evidence="ECO:0007829|PDB:6WEO"
FT STRAND 74..76
FT /evidence="ECO:0007829|PDB:6WEO"
FT TURN 77..79
FT /evidence="ECO:0007829|PDB:6WEO"
FT HELIX 88..102
FT /evidence="ECO:0007829|PDB:6WEO"
FT TURN 106..109
FT /evidence="ECO:0007829|PDB:6WEO"
FT HELIX 114..128
FT /evidence="ECO:0007829|PDB:6WEO"
FT TURN 129..131
FT /evidence="ECO:0007829|PDB:6WEO"
FT HELIX 139..154
FT /evidence="ECO:0007829|PDB:6WEO"
FT HELIX 156..165
FT /evidence="ECO:0007829|PDB:6WEO"
FT HELIX 167..178
FT /evidence="ECO:0007829|PDB:6WEO"
SQ SEQUENCE 179 AA; 20106 MW; ACB0F5574AA79274 CRC64;
MAVLQKSMSF SLMGTLAASC LLLIALWAQE ANALPVNTRC KLEVSNFQQP YIVNRTFMLA
KEASLADNNT DVRLIGEKLF RGVSAKDQCY LMKQVLNFTL EDVLLPQSDR FQPYMQEVVP
FLTKLSNQLS SCHISGDDQN IQKNVRRLKE TVKKLGESGE IKAIGELDLL FMSLRNACV
