ID   IL23A_CAVPO             Reviewed;         189 AA.
AC   Q6LA37;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Interleukin-23 subunit alpha;
DE            Short=IL-23 subunit alpha;
DE            Short=IL-23-A;
DE   AltName: Full=Interleukin-23 subunit p19;
DE            Short=IL-23p19;
DE   Flags: Precursor;
GN   Name=IL23A;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hartley; TISSUE=Macrophage;
RA   Shiratori I., Seya T.;
RT   "Molecular cloning and functional characterization of guinea pig
RT   interleukin-23.";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associates with IL12B to form the pro-inflammatory cytokine
CC       IL-23 that plays different roles in innate and adaptive immunity.
CC       Released by antigen-presenting cells such as dendritic cells or
CC       macrophages, binds to a heterodimeric receptor complex composed of
CC       IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate
CC       the receptor to form a docking site leading to the phosphorylation of
CC       STAT3 and STAT4. This process leads to activation of several pathways
CC       including p38 MAPK or NF-kappa-B and promotes the production of pro-
CC       inflammatory cytokines such as interleukin-17A/IL17A. In turn,
CC       participates in the early and effective intracellular bacterial
CC       clearance. Promotes the expansion and survival of T-helper 17 cells, a
CC       CD4-positive helper T-cell subset that produces IL-17, as well as other
CC       IL-17-producing cells. {ECO:0000250|UniProtKB:Q9NPF7}.
CC   -!- SUBUNIT: Heterodimer with IL12B; disulfide-linked. The heterodimer is
CC       known as interleukin IL-23. Interacts with IL23R; this interaction
CC       enables recruitment of IL12RB1. {ECO:0000250|UniProtKB:Q9NPF7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted upon
CC       association with IL12B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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DR   EMBL; AB058509; BAD21123.1; -; mRNA.
DR   RefSeq; NP_001166440.1; NM_001172969.1.
DR   AlphaFoldDB; Q6LA37; -.
DR   SMR; Q6LA37; -.
DR   STRING; 10141.ENSCPOP00000013451; -.
DR   Ensembl; ENSCPOT00000015072; ENSCPOP00000013451; ENSCPOG00000014926.
DR   GeneID; 100135557; -.
DR   KEGG; cpoc:100135557; -.
DR   CTD; 51561; -.
DR   eggNOG; ENOG502STAQ; Eukaryota.
DR   GeneTree; ENSGT00390000006482; -.
DR   HOGENOM; CLU_122915_0_0_1; -.
DR   InParanoid; Q6LA37; -.
DR   OMA; WARCQQL; -.
DR   OrthoDB; 1344829at2759; -.
DR   TreeFam; TF337234; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000014926; Expressed in zone of skin.
DR   GO; GO:0070743; C:interleukin-23 complex; IEA:Ensembl.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0045519; F:interleukin-23 receptor binding; IEA:Ensembl.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
DR   GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; IEA:Ensembl.
DR   GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
DR   GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
DR   GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR   GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR   GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR   GO; GO:0043382; P:positive regulation of memory T cell differentiation; IEA:Ensembl.
DR   GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
DR   GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IEA:Ensembl.
DR   GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
DR   GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
DR   GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR   GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; IEA:Ensembl.
DR   GO; GO:2000330; P:positive regulation of T-helper 17 cell lineage commitment; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR   GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
DR   GO; GO:0048771; P:tissue remodeling; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR010831; IL-23_alpha.
DR   PANTHER; PTHR15947; PTHR15947; 1.
DR   Pfam; PF16649; IL23; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Antiviral defense; Cytokine; Disulfide bond; Immunity;
KW   Inflammatory response; Innate immunity; Reference proteome; Secreted;
KW   Signal; Tissue remodeling.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..189
FT                   /note="Interleukin-23 subunit alpha"
FT                   /id="PRO_0000259486"
SQ   SEQUENCE   189 AA;  20808 MW;  BE06A3C59955337F CRC64;
     MLGSTAVMLL LLLPWTAQTR AVSGSSNPSW TQCQQLSQKL CTLAWSAHPS VGHVEPPREE
     ADEETTDYVP HILCGDGCDP QGLKDNSQFC LQRIYQGLVF YQNLLGSDIF TGEPPLFPDG
     PVSQLHASLL GLSQLLQPEV HQWEPQIPSL SPNQPWQRLL LRIKILRSFQ AFVAVAARVF
     GHGAATLTP